Dairy milk, regardless of fat content, protects against postprandial hyperglycemia-mediated impairments in vascular endothelial function in adults with prediabetes by limiting oxidative stress responses that reduce nitric oxide bioavailability

McDonald, Joshua D.; Mah, Eunice; Dey, Priyankar; Olmstead, Bryan D.; Sasaki, Geoffrey Y.; Villamena, Frederick A.; Bruno, Richard S.

doi:10.1016/j.jnutbio.2018.10.002

Cited by 11 publications

(20 citation statements)

References 58 publications

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“…Second, the large amount of calcium in dairy is associated with a lower incidence of hypertension [ 48 ], which in turn reduces the risk of IHD. Third, dairy products protect against glucose-induced impairments in vascular function by limiting glucose-induced oxidative stress [ 49 ]. In addition, proteins from dairy products promote vascular function by improving nitric oxide bioavailability.…”

Section: Discussionmentioning

confidence: 99%

Association between dairy consumption and ischemic heart disease among Chinese adults: a prospective study in Qingdao

Song

Pan

et al. 2022

Nutr Metab (Lond)

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Background Previous studies linking dairy consumption with ischemic heart disease (IHD) are almost from western countries, with little from China. The present study was to explore the relationship between dairy consumption and IHD among Chinese adults. Methods The data for the present study was from the prospective cohort study of China Kadoorie Biobank in Qingdao, a total of 33,355 participants in the present study. An interviewer-administered laptop-based questionnaire was used to collect information on the consumption frequency of dairy, incident IHD cases were identified through Disease Surveillance Point System and the new national health insurance databases. Cox regression analyses were performed to estimate adjusted hazard ratios (HRs) and confidence interval for the relationship between the incidence of IHD and dairy consumption. Results The baseline survey reported that 32.4% of males and 34.6% of females consumed dairy regularly (i.e. ≥ 4 days/week). Over an average of 9.2 years follow-up, 2712 new-onset IHD were documented. Compared with participants who never or rarely consume dairy, the HR of consumed dairy regularly was 0.85(0.73–0.98) for males (P < 0.05), while no significant benefits were identified for females. Conclusions Regular dairy consumption had an inverse association to the onset of IHD among males, with no similar findings for females.

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Section: Discussionmentioning

confidence: 99%

Association between dairy consumption and ischemic heart disease among Chinese adults: a prospective study in Qingdao

Song

Pan

et al. 2022

Nutr Metab (Lond)

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“…Significant improvements in brachial artery flow mediated dilatation, oxidative stress markers and glucose metabolism, especially postprandial glucose as well as HbA1c, were observed in these participants. However, no evidence supported the benefit of milk proteins to insulin parameters and lipid profiles [ 60 , 79 , 81 ]. Glucose levels, BMI and insulin parameters were enhanced in soy protein compared to placebo [ 20 , 35 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of 79 studies investigating plasma glucose levels, 48 (60.8%) found significant improvements in one or more of the following categories: FPG, 2hPG and area under the postprandial curve (AUC) over variable timeframes up to 180 min [ 17 , 18 , 19 , 20 , 21 , 23 , 24 , 25 , 26 , 27 , 28 , 31 , 32 , 33 , 37 , 38 , 40 , 41 , 44 , 49 , 50 , 52 , 57 , 58 , 59 , 60 , 61 , 62 , 64 , 65 , 74 , 76 , 78 , 79 , 81 , 85 , 88 , 90 , 93 , 98 , 102 , 103 , 105 , 107 , 108 , 109 , 110 , 111 ]. Likewise, serum insulin levels were measured with similar classifications and recorded a comparable number of significant results (42/68 studies, 61.8%) [ …”

Section: Resultsmentioning

confidence: 99%

“…One of the notable outcome parameters reported in these studies was urinary prostanoids such as prostaglandin F2α, albeit opposite effects in this marker were observed with different interventions [ 19 , 21 , 54 ]. Measures of endothelial function, commonly through brachial artery flow-mediated dilatation but also via carotid arterial stiffness and muscle blood flow, were performed by 10 studies, of which six (60%) reported significant improvements [ 52 , 56 , 63 , 78 , 79 , 81 ]. Three studies investigated the effect on satiety and appetite and found considerable differences postintervention that translated to better health outcomes [ 43 , 64 , 86 ].…”

Section: Resultsmentioning

confidence: 99%

“…Understandably, the most assessed parameter was plasma glucose, often interpreted as FPG and/or two-hour postprandial glucose (2hPG) measured via an oral glucose tolerance test (OGTT). Of 79 studies investigating plasma glucose levels, 48 (60.8%) found significant improvements in one or more of the following categories: FPG, 2hPG and area under the postprandial curve (AUC) over variable timeframes up to 180 min [17][18][19][20][21][23][24][25][26][27][28][31][32][33]37,38,40,41,44,49,50,52,[57][58][59][60][61][62]64,65,74,76,78,79,81,85,88,90,93,98,102,103,105,[107][108][109][110]…”

Section: Glucose-and Insulin-related Parametersmentioning

confidence: 99%

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Nutritional Strategies in Prediabetes: A Scoping Review of Recent Evidence

Yau¹,

Thor²,

Ramadas³

2020

Nutrients

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Nutritional therapy has been conventionally recommended for people with prediabetes as a method to delay or halt progression to type 2 diabetes. However, recommended nutritional strategies evolve over time. Hence, we performed a scoping review on recently reported nutritional interventions for individuals with prediabetes. Ovid MEDLINE, PubMed, Embase, Scopus, CINAHL and PsycINFO databases were searched to identify relevant research articles published within the past 10 years. Ninety-five articles involving a total of 11,211 participants were included in this review. Nutritional strategies were broadly classified into four groups: low calorie diet, low glycemic index diet, specific foods, and a combination of diet and exercise. The most frequently assessed outcomes were plasma glucose, serum insulin, serum lipid profile, body mass index and body weight. More than 50% of reported interventions resulted in significant improvements in these parameters. Nutritional interventions have demonstrated feasibility and practicality as an effective option for prediabetes management. However, the intervention variability demonstrates the challenges of a ‘one-size-fits-all’ approach. Investigations in genetically diverse populations and objective assessment of progression rate to diabetes are necessary to better comprehend the impact of these nutritional strategies in prediabetes.

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