Dairy milk proteins attenuate hyperglycemia-induced impairments in vascular endothelial function in adults with prediabetes by limiting increases in glycemia and oxidative stress that reduce nitric oxide bioavailability

McDonald, Joshua D.; Mah, Eunice; Chitchumroonchokchai, Chureeporn; Dey, Priyankar; Labyk, Allison N.; Villamena, Frederick A.; Volek, Jeff S.; Bruno, Richard S.

doi:10.1016/j.jnutbio.2018.09.018

Cited by 24 publications

(39 citation statements)

References 55 publications

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“…Previous studies on the relation of oxidative stress damage and whey protein supplementation have different conclusions. Some studies believe that supplement whey protein can increase the levels of oxidative stress products [21,22], while others showed whey protein can reduce oxidative damage [23][24][25]. During our experiment session, oxidative stress products MDA was increased by 20.7% on days 14, anti-oxidative enzymes SOD was increased by 13.4% on days 14, and GSH was increased by 16.7% and 29.1% on days 7 and 14 after whey preload.…”

Section: Effects Of Whey Preload On Plasma Stress Hormones In Gdm Womenmentioning

confidence: 65%

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

Feng

Song

et al. 2020

Preprint

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Background Whey protein (WP) intake has been shown to improve hperglycemia. Objective The aim of this study was to investigate the change of stress hormones, oxidative stress and insulin resistance (IR) in women with gestational diabetes mellitus (GDM) after supplement whey protein, in an attempt to gain insights into the prevention and treatment of GDM. Methods 60 GDM women were recruited in this study, and 30 women receive a preload drink containing 25 g whey protein as group GDM-W, and the other 30 women receive control flavoring drink as group GDM, and the trial last for 14 days. Plasma epinephrine (E), noradrenaline (NE), and cortisol were detected, we also investigate levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH). Homeostasismodel assessment of insulin resistance (HOMA-IR) was used to assesse IR. Results In GDM-W group, postprandial blood glucose was decreased significantly on 3d, 5d, 7d and 14d (p < 0.05), plasma 2 h insulin was increased by 7.2%, 8.6% and 20.5% on days 5, 7 and 14 (p < 0.05). HOMA-IR was decreased significantly on days 14 (P < 0.01). MDA was increased by 20.7% on days 14 (P < 0.01), and anti-oxidative enzymes SOD was increased by 13.4% on days 14 (P < 0.01) and GSH was increased by 16.7% and 29.1% on days 7 and 14 (both P < 0.05). Stress hormones E and cortisol were decreased by 10.8% and 19.8% respectively on days 14 (p < 0.05). Conclusions Whey protein supplementation may improve hyperglycemia by alleviate stress disorder and oxidative stress injury in GDM women.

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Section: Effects Of Whey Preload On Plasma Stress Hormones In Gdm Womenmentioning

confidence: 65%

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

Feng

Song

et al. 2020

Preprint

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“…Significant improvements in brachial artery flow mediated dilatation, oxidative stress markers and glucose metabolism, especially postprandial glucose as well as HbA1c, were observed in these participants. However, no evidence supported the benefit of milk proteins to insulin parameters and lipid profiles [ 60 , 79 , 81 ]. Glucose levels, BMI and insulin parameters were enhanced in soy protein compared to placebo [ 20 , 35 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of 79 studies investigating plasma glucose levels, 48 (60.8%) found significant improvements in one or more of the following categories: FPG, 2hPG and area under the postprandial curve (AUC) over variable timeframes up to 180 min [ 17 , 18 , 19 , 20 , 21 , 23 , 24 , 25 , 26 , 27 , 28 , 31 , 32 , 33 , 37 , 38 , 40 , 41 , 44 , 49 , 50 , 52 , 57 , 58 , 59 , 60 , 61 , 62 , 64 , 65 , 74 , 76 , 78 , 79 , 81 , 85 , 88 , 90 , 93 , 98 , 102 , 103 , 105 , 107 , 108 , 109 , 110 , 111 ]. Likewise, serum insulin levels were measured with similar classifications and recorded a comparable number of significant results (42/68 studies, 61.8%) [ …”

Section: Resultsmentioning

confidence: 99%

“…One of the notable outcome parameters reported in these studies was urinary prostanoids such as prostaglandin F2α, albeit opposite effects in this marker were observed with different interventions [ 19 , 21 , 54 ]. Measures of endothelial function, commonly through brachial artery flow-mediated dilatation but also via carotid arterial stiffness and muscle blood flow, were performed by 10 studies, of which six (60%) reported significant improvements [ 52 , 56 , 63 , 78 , 79 , 81 ]. Three studies investigated the effect on satiety and appetite and found considerable differences postintervention that translated to better health outcomes [ 43 , 64 , 86 ].…”

Section: Resultsmentioning

confidence: 99%

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Nutritional Strategies in Prediabetes: A Scoping Review of Recent Evidence

Yau¹,

Thor²,

Ramadas³

2020

Nutrients

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Nutritional therapy has been conventionally recommended for people with prediabetes as a method to delay or halt progression to type 2 diabetes. However, recommended nutritional strategies evolve over time. Hence, we performed a scoping review on recently reported nutritional interventions for individuals with prediabetes. Ovid MEDLINE, PubMed, Embase, Scopus, CINAHL and PsycINFO databases were searched to identify relevant research articles published within the past 10 years. Ninety-five articles involving a total of 11,211 participants were included in this review. Nutritional strategies were broadly classified into four groups: low calorie diet, low glycemic index diet, specific foods, and a combination of diet and exercise. The most frequently assessed outcomes were plasma glucose, serum insulin, serum lipid profile, body mass index and body weight. More than 50% of reported interventions resulted in significant improvements in these parameters. Nutritional interventions have demonstrated feasibility and practicality as an effective option for prediabetes management. However, the intervention variability demonstrates the challenges of a ‘one-size-fits-all’ approach. Investigations in genetically diverse populations and objective assessment of progression rate to diabetes are necessary to better comprehend the impact of these nutritional strategies in prediabetes.

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Section: Discussionmentioning

confidence: 99%

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

Feng

Wang

et al. 2021

Preprint

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AimTo investigate the change of stress hormones, oxidative stress and insulin resistance (IR) in women with gestational diabetes mellitus (GDM) after supplement whey protein, in an attempt to gain insights into the prevention and treatment of GDM.Methods60 GDM women were recruited in this study, and 30 women receive a preload drink containing 25 g whey protein as group GDM-W, and the other 30 women receive control flavoring drink as group GDM, and the trial last for 14 days. Plasma epinephrine (E), noradrenaline (NE), and cortisol were detected, we also investigate levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH). Homeostasismodel assessment of insulin resistance (HOMA-IR) was used to assesse IR.ResultsIn GDM-W group, postprandial blood glucose was decreased significantly on 3d, 5d, 7d and 14d (p < 0.05), plasma 2h insulin was increased by 7.2%, 8.6% and 20.5% on days 5, 7 and 14 (p < 0.05). HOMA-IR was decreased significantly on days 14 (P < 0.01). MDA was increased by 20.7% on days 14 (P < 0.01), and anti-oxidative enzymes SOD was increased by 13.4% on days 14 (P < 0.01) and GSH was increased by 16.7% and 29.1% on days 7 and 14 (both P < 0.05). Stress hormones E and cortisol were decreased by 10.8% and 19.8% respectively on days 14 (p < 0.05).ConclusionWhey protein supplementation may improve hyperglycemia by alleviate stress disorder and oxidative stress injury in GDM women.This trial was registered at chictr.org.cn/ as ChiCTR1800020413.

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Dairy milk proteins attenuate hyperglycemia-induced impairments in vascular endothelial function in adults with prediabetes by limiting increases in glycemia and oxidative stress that reduce nitric oxide bioavailability

Cited by 24 publications

References 55 publications

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

Nutritional Strategies in Prediabetes: A Scoping Review of Recent Evidence

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

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