Daily variations of serotonin metabolism in the rat brain

Héry, F.; Rouer, Évelyne; Głowiński, J.

doi:10.1016/0006-8993(72)90400-3

Cited by 236 publications

(49 citation statements)

References 22 publications

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“…This time has been shown by several workers (Scheving, Harrison, Gordon & Pauly, 1968;Quay, 1968) to coincide with a rapid fall in 5-HT content of the brain, amounting in some regions to between 25 and 36 %. Hery, Rouer & Glowinski (1972) explain this fall by their observation that 5-HT release reaches a maximum, and synthesis a minimum, during the early hours of darkness. The use of males in the present work and of females previously can only have had a very small effect on the 5-HT concentrations, because on averaging the 5-HT content of pons-medulla in the different phases of the oestrous cycle the mean for females is hardly greater than that for males.…”

Section: Sensitivity To Morphine In Normal Ratsmentioning

confidence: 99%

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

Vogt¹

1974

The Journal of Physiology

205

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SUMMARY1. Injection of 5,6-dihydroxytryptamine (5, 50 ,tg) into a lateral cerebral ventricle of male rats lowered the 5-hydroxytryptamine (5-HT) content of the lumbar cord to 12.8% and reduced the analgesic effect of low doses of morphine (0.64-1.63 mg/kg), tested by exerting pressure on the foot; after doses of morphine of 1.33-1-63 mg/kg, the analgesic response was reduced or abolished in 33 % of the rats, and after 0*64 mg/kg, 58 % of the animals failed to respond normally.2. Two days after an i.P. injection of p-chlorophenylalanine (pCPA, 320 mg/kg), the loss of analgesic potency of morphine was more pronounced than after intraventricular 5,6-HDT. The 5-HT content was lowered to about 8% in the lumbar cord, and to 20% or less in pons and medulla.3. The experiments show that interference with the descending tryptaminergic axons innervating the cord is by itself sufficient to reduce analgesia due to morphine, but they do not exclude the possibility that other tryptaminergic neurones take part in the effect of pCPA. The contribution to the analgesic effect of morphine made by the interaction of tryptaminergic axons with the interneurones 'gating' the afferent impulses in the posterior columns is discussed.

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Section: Sensitivity To Morphine In Normal Ratsmentioning

confidence: 99%

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

Vogt¹

1974

The Journal of Physiology

205

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“…The concept that the neuronal activities of brain monoamines may be assessed from the ratio of the neuronal metabolite concentration to the concentration of the parent monoamine (Hery et al 1972;Mena et al 1976;Heffner et al 1980) is well supported by theory and practice (Smythe et al 1983). Computerized gas chromatography-mass spectrometry using deuterated internal standards provides a method of analysing brain monoamine and metabolite concentrations with high precision and specificity (Smythe et al 1982a(Smythe et al , 1983.…”

Section: Introductionmentioning

confidence: 99%

Effects of 6-Methoxy-l,2,3,4-tetrahydro-b-carboline and Yohimbine on Hypothalamic Monoamine Status and Pituitary Hormone Release in the Rat

Smythe¹,

Duncan²,

Bradshaw³

et al. 1983

Aust. Jnl. Of Bio. Sci.

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Shortly after administration of 6-methoxy-1,2,3,4-tetrahydro-ft-carboline (6-MeOTHBC) and yohimbine to normal or hypothyroid rats [the latter exhibiting chronically elevated levels of serotonin (5-HT) neuronal activity in the hypothalamus] there was a highly significant increase in hypothalamic noradrenaline (NA) activity and in ACTH release concomittant with a reduction in hypothalamic 5-HT activity (P< 0'01) and in growth hormone (GH) (P

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“…However, the data on daily variations in hypothalamic NE content do not include a value at about 17:00 hr when hypothalamic NE uptake is also at a minimum. A similar analogy between a rhythm in endogenous transmitter level and periodicity in neuronal processes in vitro has been observed for hypothalamic serotonin (5-HT) [14].…”

Section: Discussionmentioning

confidence: 74%

Norepinephrine uptake by hypothalamic tissue from the rat related to feeding

Gugten

Slangen

1975

Pharmacology Biochemistry and Behavior

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VAN DER GUGTEN, J. AND J. L. SLANGEN. Norepinephrine uptake by hypothalamic tissue from the rat related to feeding. PHARMAC. BIOCHEM. BEHAV. 3(5) 855-860, 1975. -Norepinephrine (NE) uptake by rat hypothalamus in vitro was studied in relation to food intake. Significant daily variations in NE uptake were observed in caudal hypothalamus from freely feeding rats. A maximal elevation occurred at the beginning of the night when food intake is also increasing to a maximum. NE uptake by caudal hypothalamus from relatively hungry rats previously adjusted to restricted feeding during the daytime was enhanced in afternoon and evening when compared with uptake by tissue from ad lib feeding animals. Determination of NE uptake by caudal hypothalamus from freely feeding individual rats and registration of individual meals taken by these rats revealed a relation between hypothalamic neuronal activity and the feeding pattern of the rat. A positive correlation was observed between NE uptake in vitro and feeding rate during a 2-to 4-hr interval. It also appeared that NE uptake by caudal hypothalamus is dependent on the time elapsed after the last meal. The data were evaluated in view of physiological studies concerning the onset of feeding and the hypothesis of hypothalamic adrenergic control of food intake. Norepinephrine uptakeCaudal hypothalamus Circadian rhythm Meal pattern Adrenergic feeding system Food intake regulation Food deprivation Restricted feeding PREVIOUS studies suggest a role for central adrenergic systems in the regulation of feeding behavior. Intrahypothalamic administration of L-norepinephrine (NE) has been shown to induce eating in food satiated rats [2,12]. It has been found that only a-adrenergic receptor agonists elicit eating in satiated rats and that this effect can be prevented by central application of an a-adrenergic blocking agent and not by a /3-adrenergic antagonist [3,25]. It has also been shown that inhibitors of the reuptake of NE into nerve terminals augment the eating response to exogenous NE in satiated rats [3,25], whereas intrahypothalamic administration of an uptake inhibitor enhances food intake in food deprived rats [21]. These findings can be interpreted as evidence that adrenoceptors in the hypothalamus are components of a feeding system. In addition, other central adrenergic mechanisms may play a role in the control of ingestive behavior [ 18,24]. If a hypothalamic adrenergic system is involved in the regulation of feeding in the rat the activity of such a system should change in relation to the need for food. The present study deals with the relation between NE uptake by hypothalamic tissue in vitro and feeding. As there is a circadian rhythm in food intake, daily variations in NE uptake by brain tissue from freely feeding animals were investigated. The effects of altered feeding conditions on this biochemical parameter were also studied. Finally, data concerning the relation between hypothalamic NE uptake and the individual feeding pattern of the rat are presented. METHOD

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Daily variations of serotonin metabolism in the rat brain

Cited by 236 publications

References 22 publications

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

Effects of 6-Methoxy-l,2,3,4-tetrahydro-b-carboline and Yohimbine on Hypothalamic Monoamine Status and Pituitary Hormone Release in the Rat

Norepinephrine uptake by hypothalamic tissue from the rat related to feeding

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