Daily urinary interleukin-11 excretion correlated with proteinuria in IgA nephropathy and lupus nephritis

Chien, Jien‐Wen; Chen, Woan-Ling; Tsui, Y.-C.; Lee, Min-Chun; Lin, An-Yi; Lin, Ching‐Yuang

doi:10.1007/s00467-006-0016-7

Cited by 16 publications

(13 citation statements)

References 31 publications

(24 reference statements)

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“…Although a possible imbalance in Th1/Th2 proinflammatory cytokines release has been reported to play a pivotal role in the pathogenesis of immunocomplex-mediated glomerulonephritis [2][3][4][7][8][9], there is little information on Th1 or Th2 predominance in HSPN. With respect to Th1/Th2 predominance in IgA nephropathy, a model of IgA nephropathy in ddY mice has been reported to show strong polarization toward Th1 in the early stage of the disease [5].…”

Section: Discussionmentioning

confidence: 98%

“…Although the pathogenesis of HSPN remains to be elucidated, presumptive inflammatory reactions due to predominant immunoglobulin A (IgA) deposition in the mesangium is thought to play a pivotal role, similar to its role in IgA nephropathy [1]. The results from recent studies suggest the possible role of an imbalance in Th1/Th2 proinflammatory cytokines in the development and progression of glomerulonephritis, including IgA nephropathy [2][3][4][5]. However, to the best of our knowledge, there is little information on Th1 or Th2 predominance in HSPN.…”

Section: Introductionmentioning

confidence: 96%

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Imbalance towards Th1 pathway predominance in purpura nephritis with proteinuria

et al. 2011

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Although recent reports suggest a possible role for an imbalance in Th1 and Th2 proinflammatory cytokines in the development and progression of glomerulonephritis, there is little information on Th1 or Th2 predominance in Henoch-Schönlein purpura nephritis (HSPN). Since T-bet and GATA-3 are transcriptional factors that regulate the differentiation of helper T lymphocytes into Th1 and Th2, we examined the relative mRNA expression of T-bet and GATA-3 in the urinary sediment of children with proteinuric HSPN by real-time quantitative PCR. Eight consecutive patients with proteinuric HSPN (4 with grade IIIa and 4 with grade IIIb according to the International Study of Kidney Disease in Children criteria) and 20 healthy subjects were enrolled in this study. The relative expression level of T-bet was significantly higher in the urinary sediment of patients with HSPN at presentation than in that of the healthy controls (p = 0.021), while the relative expression of GATA-3 was significantly lower in the urinary sediment of patients than in that of controls (p = 0.002). Urinary mRNA expression of T-bet correlated with the urinary protein/creatinine ratio (r = 0.608, p = 0.013), and correlated inversely with serum level of total protein (r = -0.574, p = 0.020). Moreover, a significantly increased intensity of T-bet immunostaining was observed in the glomeruli in the biopsy specimen of all study patients. All patients received immunosuppressive therapy. Repeat measurements of urinary mRNA expression of T-bet and GATA-3 after treatment revealed that the expression of T-bet in patients had significantly decreased relative to the baseline (p = 0.003), while the expression of GATA-3 remained static. In a patient subjected to a post-treatment renal biopsy, the increased intensity of immunostaining of T-bet had clearly diminished following immunosuppressive treatment, in accordance with a significant decrease in urinary mRNA expression of T-bet. These observations suggest that patients with proteinuric HSPN demonstrate increased T-bet and depressed GATA-3 expression in the urinary sediment, indicating a possible shift in Th1/Th2 balance towards Th1 predominance.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 96%

Imbalance towards Th1 pathway predominance in purpura nephritis with proteinuria

et al. 2011

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“…The significance of the TI compartment in LN disease has been a topic of much interest, and, for many years, authors have suggested that examination of the TI compartment might be useful for predicting outcome in LN [6,26]. Recently, studies of urinary biomarkers in LN kidney injury suggest that biomarkers may play a role in diagnosis and risk stratification of kidney damage [24,[27][28][29]. Presumably, biomarkers of tubular injury would correlate more highly with a TI index than a glomerular index [28,29]; but whether this is true is unknown.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of activity, chronicity and tubulointerstitial indices for childhood lupus nephritis

et al. 2008

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Few data exist on use of the National Institutes of Health (NIH) activity index (AI) and chronicity index (CI) in childhood lupus nephritis (LN). A tubulointerstitial activity index (TIAI) has been derived but not validated. We evaluated clinicopathologic correlations of the AI, CI and TIAI in children with LN who had undergone initial renal biopsy (n=25, age 12.4+/-2.7 years, biopsy 1) and 1 year after treatment (n=15, biopsy 2). The TIAI correlated with the AI at biopsy 1 (r=0.76, P=0.001) and biopsy 2 (r=0.52, P=0.05), but not with CI scores. Mean AI and CI scores changed substantially from biopsy 1 to biopsy 2 (P<0.05), but TIAI scores did not. Higher AI and TIAI scores correlated with proteinuria at both biopsies (r=0.51-0.76, P<0.05); CI scores correlated with estimated creatinine clearance (r=0.46-0.58, P<0.05). Improved AI score from biopsy 1 to biopsy 2 was associated with decrease in proteinuria. These results suggest that the AI and CI are useful in childhood LN. The TIAI may be a valid measure to evaluate the tubulointerstitium, but research is needed to define its responsiveness to change with therapy.

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“…Recent reports have suggest that an imbalance between Th1 and Th2 cells might be associated with the development and progression of several forms of glomerulonephritis [2,3]. Most patients with LN or IgAN are thought to exhibit Th1/Th2 heterogeneity; however, no clear evidence of this exists [4][5][6]. Rengarajan et al reported that the relative predominance of T-bet or GATA-3 may determine Th1/Th2 polarization [7].…”

Section: Introductionmentioning

confidence: 96%

Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis

et al. 2007

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Recent studies have suggested that gene expression studies using urinary sediment might be a non-invasive approach to assessing activity and pathogenesis in glomerulonephritis. However, little information is available regarding the mRNA expression patterns of functional molecules, such as T-bet, GATA-3, FOXP3, and retinoic acid-inducible gene-I (RIG-I), in urinary sediment, from patients with immunocomplex-mediated glomerulonephritis. Fourteen lupus nephritis (LN) patients, 13 IgA nephropathy (IgAN) patients, and 12 healthy controls were enrolled in the study. The mRNA expressions of T-bet, GATA-3, FOXP3 and RIG-I in urinary sediment were measured using real time quantitative polymerase chain reaction. We also studied the expression of RIG-I in kidney tissue specimens obtained from LN and IgAN patients. Significant differences in the expression patterns of GATA-3, FOXP3 and RIG-I, and marginal differences in T-bet expression, were observed between the three study groups. Immunofluorescent staining for RIG-I was observed in the tissue specimens from the LN patients, but not in those from the IgAN patients. The mRNA expression patterns of T-bet, GATA-3, FOXP3 and RIG-I in urinary sediment differ according to diagnostic category. These results suggest that the measurement of these target gene expressions might be a useful, non-invasive method for clinical monitoring and studying of pathogenesis in glomerulonephritis.

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Daily urinary interleukin-11 excretion correlated with proteinuria in IgA nephropathy and lupus nephritis

Cited by 16 publications

References 31 publications

Imbalance towards Th1 pathway predominance in purpura nephritis with proteinuria

Imbalance towards Th1 pathway predominance in purpura nephritis with proteinuria

Evaluation of activity, chronicity and tubulointerstitial indices for childhood lupus nephritis

Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis

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