Daily scheduling of the golden spiny mouse under photoperiodic and social cues

Zisapel, Nava; Barnea, Eilon; Izhaki, Ido; Anis, Yossi; Haim, Abraham

doi:10.1002/(sici)1097-010x(19990615)284:1<100::aid-jez13>3.0.co;2-5

Cited by 9 publications

(8 citation statements)

References 13 publications

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“…The lability of its temporal organisation expressed by daily rhythms reveals an ability to act both as a diurnal and as a nocturnal animal depending on the presence of its sibling competitor A. cahirinus (Haim and Rozenfeld, 1993). Results of several studies (Zisapel et al, 1999;Cohen et al, 2009;Cohen et al, 2010) have emphasised the plasticity of its circadian system. This concurs with the rapid changes in the parameters of A. russatus assayed in our study.…”

Section: Discussionmentioning

confidence: 99%

Light Interference (LI) as a possible stressor altering HSP70 and its gene expression levels in brain and liver tissues of Golden Spiny Mice

Ashkenazi

Haim

2012

Journal of Experimental Biology

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SUMMARYLight at night and light interference (LI) disrupt the natural light:dark cycle, causing alterations at physiological and molecular levels, partly by suppressing melatonin (MLT) secretion at night. Heat shock proteins (HSPs) can be activated in response to environmental changes. We assessed changes in gene expression and protein level of HSP70 in brain and hepatic tissues of golden spiny mice (Acomys russatus) acclimated to LI for two (SLI), seven (MLI) and 21 nights (LLI). The effect of MLT treatment on LI-mice was also assessed. HSP70 levels increased in brain and hepatic tissues after SLI, whereas after MLI and LLI, HSP70 decreased to control levels. Changes in HSP70 levels as a response to MLT occurred after SLI only in hepatic tissue. However, hsp70 expression following SLI increased in brain tissue, but not in hepatic tissue. MLT treatment and SLI caused a decrease in hsp70 levels in brain tissue and an increase in hsp70 in hepatic tissue. SLI acclimation elicited a stress response in A. russatus, as expressed by increased HSP70 levels and gene expression. Longer acclimation decreases protein and gene expression to their control levels. We conclude that for brain and hepatic tissues of A. russatus, LI is a short-term stressor. Our results also revealed that A. russatus can acclimate to LI, possibly because of its circadian system plasticity, which allows it to behave both as a nocturnal and as a diurnal rodent. To the best of our knowledge, this is the first study showing the effect of LI as a stressor at the cellular level, by activating HSP70. Supplementary material available online at

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Section: Discussionmentioning

confidence: 99%

Light Interference (LI) as a possible stressor altering HSP70 and its gene expression levels in brain and liver tissues of Golden Spiny Mice

Ashkenazi

Haim

2012

Journal of Experimental Biology

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“…The common spiny mouse (Acomys cahirinus) and the golden spiny mouse (A. russatus) coexist in rocky habitats (Kronfeld-Schor et al 2001a;Shkolnik 1966Shkolnik , 1971 where they overlap in microhabitat use, home ranges, food habits, and reproductive period (Kronfeld et al 1994(Kronfeld et al , 1996Kronfeld-Schor & Dayan 1999;Shargal et al 2000). These species have attracted attention (e.g., Fluxman & Haim 1993;Haim & Borut 1981;Shkolnik 1971;Shkolnik & Borut 1969;Zisapel et al 1998Zisapel et al , 1999 owing to their unique temporal activity patterns: The common spiny mouse is active during the night, as are most desert rodents, whereas the golden spiny mouse is active during the day. Shkolnik (1966Shkolnik ( , 1971 repeatedly trapped all individual A. cahirinus from a joint habitat, a rock pile, and after several months he began to trap A. russatus individuals during the night.…”

Section: Activity Patternsmentioning

confidence: 99%

Partitioning of Time as an Ecological Resource

Kronfeld‐Schor

Dayan

2003

Annu. Rev. Ecol. Evol. Syst.

770

684

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s Abstract Animal species have evolved different diel activity rhythms that are of adaptive value. Theory suggests that diel temporal partitioning may facilitate coexistence between competitors and between predators and prey. However, relatively few studies demonstrate a temporal shift that is predation-or competition-induced. Recorded shifts are usually within the preferred activity phase of animal species (day or night), although there are some inversions to the opposite phase cycle. Temporal partitioning is not perceived as a common mechanism of coexistence. This rarity has been variously ascribed to theoretical considerations and to the rigidity of time-keeping mechanisms, as well as to other physiological and anatomical traits that may constrain activity patterns. Our decade-long study of spiny mice of rocky deserts demonstrates that, while different factors select for activity patterns, endogenous rhythmicity may be an evolutionary constraint.

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“…Administration of melatonin during daytime (when it is not present endogenously) results in induction of fatigue and sleepiness in humans [63]. Importantly, melatonin is not sedating: in nocturnally active animals melatonin is associated with wake, not sleep, periods [64], and in humans its sleep-promoting effects become significant about 2 h after intake similar to the physiological sequence at night [46]. Importantly, melatonin potentiates the effects of GABA-A receptor modulators (i.e.…”

Section: Homeostatic and Circadian Sleep Regulationmentioning

confidence: 99%

“…Vol. 64,2007 of melatonin on brain activity are essentially different from those seen after sleep deprivation, although both treatments result in induction of fatigue [67]. Because melatonin does not increase the amount of SWS [68], which is considered a marker of the homeostatic sleep drive [69], the sleep-promoting effects of melatonin may be mostly ascribed to the circadian component of sleep regulation.…”

Section: Homeostatic and Circadian Sleep Regulationmentioning

confidence: 99%

Sleep and sleep disturbances: biological basis and clinical implications

Zisapel

2007

Cell. Mol. Life Sci.

169

120

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Sleep is a neurochemical process involving sleep promoting and arousal centers in the brain. Sleep performs an essential restorative function and facilitates memory consolidation in humans. The remarkably standardized bouts of consolidated sleep at night and daytime wakefulness reflect an interaction between the homeostatic sleep need that is manifested by increase in sleep propensity after sleep deprivation and decrease during sleep and the circadian pacemaker. Melatonin, the hormone produced nocturnally by the pineal gland, serves as a time cue and sleep-anticipating signal. A close interaction exists between the sleep-wake, melatonin, core temperature, blood pressure, immune and hormonal rhythms leading to optimization of the internal temporal order. With age the robustness of the circadian system decreases and the prevalence of sleep disorders, particularly insomnia, increases. Deviant sleep patterns are associated with increased risks of morbidity, poor quality of life and mortality. Current sleep pharmacotherapies treat insufficient sleep quantity, but fail to improve daytime functioning. New treatment modalities for sleep disorders that will also improve daytime functioning remain a scientific and medical challenge.

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Daily scheduling of the golden spiny mouse under photoperiodic and social cues

Cited by 9 publications

References 13 publications

Light Interference (LI) as a possible stressor altering HSP70 and its gene expression levels in brain and liver tissues of Golden Spiny Mice

Light Interference (LI) as a possible stressor altering HSP70 and its gene expression levels in brain and liver tissues of Golden Spiny Mice

Partitioning of Time as an Ecological Resource

Sleep and sleep disturbances: biological basis and clinical implications

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