Daily rhythms in heartbeat rate are intrinsic to the zebrafish heart

Fong, Chun Ki; Hearn, Timothy J.; Webb, Sarah; Steindal, Inga A. Frøland; Miller, Andrew L.; Whitmore, David

doi:10.1016/j.cub.2021.01.106

Cited by 3 publications

(3 citation statements)

References 9 publications

(14 reference statements)

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“…The cardiac effects could be due to minor inconspicuous developmental disturbances in the survived embryos or the possible selective mortality of fish with a slower heart rate in HMF. Patterns of circadian rhythm in the zebrafish heartbeat rate obtained in this experiment are consistent with the available data (Fong et al, 2021). Some studies described the influence of magnetic and electromagnetic fields on molecular oscillators and circadian rhythms in other species (Manzella et al, 2015;Agliassa and Maffei, 2019;Bartos et al, 2019).…”

Section: Discussionsupporting

confidence: 90%

“…The heart rate has a pronounced circadian rhythm . For example, the heart rate in larval zebrafish increases in the light and decreases in the dark phase (Fong et al, 2021). Zebrafish heart contains its circadian pacemaker at the gene expression level (Whitmore et al, 2000), and the daily change in heartbeat rate remains in excised larval hearts in vitro (Fong et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…For example, the heart rate in larval zebrafish increases in the light and decreases in the dark phase (Fong et al, 2021). Zebrafish heart contains its circadian pacemaker at the gene expression level (Whitmore et al, 2000), and the daily change in heartbeat rate remains in excised larval hearts in vitro (Fong et al, 2021). Some works describe the effect of magnetic influences on circadian patterns in the rhythms of cardiac function (Makarov, 1997;Chibisov et al, 2004;McCraty et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Influence of hypomagnetic field on the heartbeat in zebrafish embryos

Крылов

Мачихин²,

Sizov³

et al. 2022

Front. Physiol.

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The magnetic environment may influence the functioning of the cardiovascular system. It was reported that low-frequency and static magnetic fields affect hemodynamics, heart rate, and heart rate variability in animals and humans. Moreover, recent data suggest that magnetic fields affect the circadian rhythms of physiological processes. The influence of the magnetic environment on heart functionating during early development has been studied insufficiently. We utilized transparent zebrafish embryos to evaluate the effect of the hypomagnetic field on the characteristics of cardiac function using a noninvasive optical approach based on photoplethysmographic microscopic imaging. The embryos were exposed to the geomagnetic and hypomagnetic fields from the second to the 116th hour post fertilization under a 16 h light/8 h dark cycle or constant illumination. The exposure of embryos to the hypomagnetic field in both lighting modes led to increased embryo mortality, the appearance of abnormal phenotypes, and a significant increase in the embryo’s heartbeat rate. The difference between maximal and minimal heartbeat intervals, maximal to minimal heartbeat intervals ratio, and the coefficient of variation of heartbeat rate were increased in the embryos exposed to the hypomagnetic field under constant illumination from 96 to 116 h post fertilization. The dynamics of heartbeat rate changes followed a circadian pattern in all studied groups except zebrafish exposed to the hypomagnetic field under constant illumination. The results demonstrate the importance of natural magnetic background for the early development of zebrafish. The possible mechanisms of observed effects are discussed.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of hypomagnetic field on the heartbeat in zebrafish embryos

Крылов

Мачихин²,

Sizov³

et al. 2022

Front. Physiol.

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The dark side of the fish: Common adaptations in cavefishes from around the world

Frøland Steindal

2024

Encyclopedia of Fish Physiology

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Ion dynamics and the regulation of circadian cellular physiology

Stangherlin

2023

American Journal of Physiology-Cell Physiology

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Circadian rhythms in physiology and behaviour allow organisms to anticipate the daily environmental changes imposed by the rotation of our planet around its axis. Although these rhythms eventually manifest at the organismal level, a cellular basis for circadian rhythms has been demonstrated. Significant contributors to these cell-autonomous rhythms are daily cycles in gene expression and protein translation. However, recent data revealed cellular rhythms in other biological processes, including ionic currents, ion transport, and cytosolic ion abundance. Circadian rhythms in ion currents sustain circadian variation in action potential firing rate, which coordinates neuronal behaviour and activity. Circadian regulation of metal ions abundance and dynamics is implicated in distinct cellular processes, from protein translation to membrane activity and osmotic homeostasis. In turn, studies showed that manipulating ion abundance affects the expression of core clock genes and proteins, suggestive of a close interplay. However, the relationship between gene expression cycles, ion dynamics and cellular function is still poorly characterised. In this review, I will discuss the mechanisms that generate ion rhythms, the cellular functions they govern and how they feed back to regulate the core clock machinery.

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Daily rhythms in heartbeat rate are intrinsic to the zebrafish heart

Abstract: If it is the author's pre-published version, changes introduced as a result of publishing processes such as copy-editing and formatting may not be reflected in this document. For a definitive version of this work, please refer to the published version.

Cited by 3 publications

References 9 publications

Influence of hypomagnetic field on the heartbeat in zebrafish embryos

Influence of hypomagnetic field on the heartbeat in zebrafish embryos

The dark side of the fish: Common adaptations in cavefishes from around the world

Ion dynamics and the regulation of circadian cellular physiology

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