Daily rhythm of S32 incorporation into epiphyseal cartilage in mice

Simmons, David J.

doi:10.1007/bf02140823

Cited by 31 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that metabolic changes occurring during darkness (Aschoff and Pohl, 1970;Aschoff and Saint Paul, 1976;Decuypere and Kuhn, 1984;Luijtelaar et al, 1987) may benefit skeletal growth. It is also of interest to speculate on the role in bone growth of circadian rhythms which are lightdependent and known to occur in mammals (Simmons, 1962(Simmons, , 1968Hansson, 1974).…”

Section: Discussionmentioning

confidence: 99%

Effects of increasing photoperiod length on performance and health of broiler chickens

Classen

Riddell

Robinson

1991

British Poultry Science

100

View full text Add to dashboard Cite

1. Broiler performance and health were compared from 0 to 42 d for lighting programmes consisting of near-continuous light 23L:1D (23L), a lighting programme where photoperiod gradually increased from 6 to 23 h between days 4 and 35 (INC) or an increasing-lighting programme with 1 h of light mid-way through the scotophase (INC + 1). 2. The increasing lighting programmes reduced growth rate and increased gain:food ratio from 0 to 21 d; INC + 1 growth rate was intermediate to the 23 L and INC treatments. From 0 to 42 d there were no differences in growth rate or gain:food ratio among lighting treatments. Males grew faster, ate more food and converted food more efficiently than females. 3. The increasing-lighting programmes (INC and INC + 1) resulted in less skeletal disease than the 23L control. The incidence of sudden death syndrome (SDS) and mortality other than SDS were numerically lower for the increasing lighting treatments. More males died as a result of SDS and were affected by skeletal defects than females. 4. In terms of health, increasing lighting programmes were superior to near-continuous light for broiler chickens.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of increasing photoperiod length on performance and health of broiler chickens

Classen

Riddell

Robinson

1991

British Poultry Science

100

View full text Add to dashboard Cite

show abstract

“…Previous investigators have shown that in growth plate cartilage, the rate of proliferative cell division, proteoglycan biosynthesis, and collagen synthesis follow a circadian rhythm of activity (Petrovic et al, 1984;Simmons and Nichols, 1966;Simmons, 1968). Twofold variations in the magnitude of these metabolic activities may occur over a 24-hr period (Simmons et al, 1979;Oudet and Petrovic, 1981).…”

Section: Circadian Influences On Long Bone Growthmentioning

confidence: 93%

“…At particular times during a 24-hr day, a maximal number of chondrocytes in rat growth plates express their proliferative potential and undergo DNA synthesis, and thus overall proliferative activity may vary by as much as 33% at different times in the light-dark cycle (Simmons et al, 1979;Oudet and Petrovic, 1981;Kember, 1983;Russell et al, 1983). Similarly, studies of rat and rabbit growth plates have shown that patterns of proteoglycan synthesis (Simmons and Nichols, 1966;Simmons, 1968;Simmons et al, 1979), alkaline phosphatase activity (Simmons et al, 1979Oudet and Petrovic, 1981), collagen synthesis (Russell et al, 1984b(Russell et al, , 1985, and matrix calcification (Oudet and Petrovic, 1981;Simmons et al, 1983;Russell et al, 1984a) follow discrete circadian rhythms. In this study we examine condensation of hypertrophic chondrocytes both as a function of circadian rhythms and as a function of overall rate of long bone growth.…”

Section: Introductionmentioning

confidence: 93%

Condensation of hypertrophic chondrocytes at the chondro‐osseous junction of growth plate cartilage in Yucatan swine: Relationship to long bone growth

Farnum¹,

Wilsman

1989

Am. J. Anat.

View full text Add to dashboard Cite

Chondrocytes of the cartilaginous growth plate are found in a spatial gradient of cellular differentiation beginning with cellular proliferation and ending with cellular hypertrophy. Although it is recognized that both proliferation and hypertrophy contribute significantly to overall bone growth, mechanisms acting on the chondrocyte to control the timing, the rate, and the extent of hypertrophy are poorly understood. Similarly, mechanisms acting on the terminal chondrocyte to cause its death at the chondro-osseous junction have not been investigated. In this study we examine the condensation of terminal hypertrophic chondrocytes in proximal and distal radial growth plates of Yucatan swine at 4 weeks of age. The animals were raised in a controlled environment where activity and feeding patterns were synchronized to a given time in the light/dark cycle. We analyzed cellular condensation both as a function of circadian rhythms in a 24-hr time period, and as a function of overall rate of growth. The data suggest that the magnitude of circadian influences on long bone growth is significantly damped at the level of the hypertrophic chondrocyte compared to that seen by previous investigators studying circadian influences on chondrocytic proliferation. Secondly, the condensation of hypertrophic chondrocytes at the chondro-osseous junction varies inversely with rate of growth in length of the bone. At any time period, a higher percentage of terminal chondrocytes in the condensed form was found in the slower-growing of the two growth plates. We relate these findings to current hypotheses concerning controls of chondrocytic hypertrophy and possible controls over the timing of hypertrophic cell death.

show abstract

“…It is known that the synthesis of matrix proteoglycans and DNA by chondrocytes shows a circadian rhythm and that cell division is also rhythmic (review : Simmons, 1992). These three cell cycle events have a specific phase relationship ; DNA synthesis occurs earliest, followed by proteoglycan synthesis and finally, cell divisions (Simmons, 1968). Therefore, it is plausible that IOP influences the synthesis of matrix molecules more at some times of day that at others, so that the phase of the IOP rhythm with respect to cellular growth events would be critical in determining the magnitude of its effect.…”

Section: Intraocular Pressure and Ocular Growthmentioning

confidence: 99%

The Circadian Rhythm in Intraocular Pressure and its Relation to Diurnal Ocular Growth Changes in Chicks

Nickla

Wildsoet

Wallman

1998

Experimental Eye Research

106

View full text Add to dashboard Cite

Daily rhythm of S32 incorporation into epiphyseal cartilage in mice

Cited by 31 publications

References 8 publications

Effects of increasing photoperiod length on performance and health of broiler chickens

Effects of increasing photoperiod length on performance and health of broiler chickens

Condensation of hypertrophic chondrocytes at the chondro‐osseous junction of growth plate cartilage in Yucatan swine: Relationship to long bone growth

The Circadian Rhythm in Intraocular Pressure and its Relation to Diurnal Ocular Growth Changes in Chicks

Contact Info

Product

Resources

About