1995
DOI: 10.1016/s0022-3476(95)70115-x
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Daily physical activity of schoolchildren with spastic diplegia and of healthy control subjects

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Cited by 133 publications
(79 citation statements)
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“…Studies in humans, including children of patients with type II diabetes and animal models selectively bred for low aerobic capacity, support the notion that impaired genetic regulation of oxidative pathways in mitochondria may be a common factor linking reduced energy transfer as a primary determinant of the complex features of metabolic syndrome [34,35]. In addition, several recent findings have emphasized the role of mitochondrial dysfunction in many neurological disorders with oxidative mechanisms of injury such as the hypoxic-ischemic injury mechanism to developing oligodendrocytes proposed for some forms of cerebral palsy [36][37][38]. This plausible association between low mitochondrial oxidative capacity and high oxygen cost of physical activity in individuals with CP has not been tested, but, if true, it could suggest a common mechanism for lower aerobic capacity accompanied by increased adiposity in this population.…”
Section: Discussionmentioning
confidence: 60%
“…Studies in humans, including children of patients with type II diabetes and animal models selectively bred for low aerobic capacity, support the notion that impaired genetic regulation of oxidative pathways in mitochondria may be a common factor linking reduced energy transfer as a primary determinant of the complex features of metabolic syndrome [34,35]. In addition, several recent findings have emphasized the role of mitochondrial dysfunction in many neurological disorders with oxidative mechanisms of injury such as the hypoxic-ischemic injury mechanism to developing oligodendrocytes proposed for some forms of cerebral palsy [36][37][38]. This plausible association between low mitochondrial oxidative capacity and high oxygen cost of physical activity in individuals with CP has not been tested, but, if true, it could suggest a common mechanism for lower aerobic capacity accompanied by increased adiposity in this population.…”
Section: Discussionmentioning
confidence: 60%
“…Similarly, children with a low degree of involvement have a lower rate of neuromuscular disorder arising from spasticity and decreased motor control which affect functional activities in daily life compared to children with a moderate and high degree of involvement (5)(6)(7)(8). However, they have less energy consumption, limited participation in physical activities and sportive activities compatible with their age compared to their healthy peers (5,9). Thus, the risk of obesity is increased in these children who are more immobile compared to healthy children.…”
Section: Introductionmentioning
confidence: 99%
“…Aerobic fitness of children or athletes with cerebral palsy has been vigorously investigated by Bar-Or 10) , Fernandez et al 23,24) , Lundberg 25,26) , Maltais et al [27][28][29][30] , van den Berg-Emons et al [31][32][33][34] , and other researchers since the 1960s. These studies were based on work physiology that was mainly established by Åstrand et al 9) .…”
Section: History Of Research On Aerobic Fitness In Individuals With Cmentioning
confidence: 99%
“…This work physiology was originally intended to provide practical information to athletes to improve their performance. Since the 1960s, physiological studies have mostly focused on the wellness of children 3,10,[25][26][27][28][31][32][33][34][35][36][37][38][39][40][41][42][43] or athletes [44][45][46][47][48][49][50][51][52][53][54] with cerebral palsy mainly rated to Gross Motor Function Classification System (GMFCS) level I or II. In the late twentieth century, many new remedies proliferated one after another in an attempt to recover loss of function in children with cerebral palsy.…”
Section: History Of Research On Aerobic Fitness In Individuals With Cmentioning
confidence: 99%