Daily Intake of Probiotics with High IFN-<i>γ</i>/IL-10 Ratio Increases the Cytotoxicity of Human Natural Killer Cells: A Personalized Probiotic Approach

Ho, Yu-Hsuan; Lu, Y.-C.; Chang, Hung-Cheng; Lee, Shin-Yi; Tsai, Min-Fen; Huang, Yu‐Ting; Hsu, Ting-Yuan

doi:10.1155/2014/721505

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…18 It has been reported that NK cell activity could be enhanced by certain strains of probiotics in humans. 19 In this review, we examine the effects of probiotics on gut immunity, specifically describing how NK cell activity and subsequently innate immunity are affected by the addition of certain probiotic strains into a human daily diet.…”

Section: Probioticsmentioning

confidence: 99%

Activation of Natural Killer Cells by Probiotics

Aziz

Bonavida

2016

Forum Immun Dis Ther

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During the last decade, probiotics have been established to be important mediators of host immunity. Their effects on both innate and adaptive immunity have been documented in the literature. Although several reports have correlated different strains of bacteria as probiotics, their effects on immunity vary. Clearly, there is a complex interplay between various constituents of probiotics and the immune response in humans. The role of probiotics on natural killer (NK) cells in the gut has been the subject of a few reports. In this review, we summarize the reported findings on the role of probiotics in the activation of gut-associated NK cells and the response of NK cells to stimuli elicited by probiotics and their microenvironment. The effects of probiotics on the activation of NK cells and their secretion of immune factors (e.g., interferon–γ, tumor necrosis factor–α, interleukin-2, etc.) are discussed in regard to their clinical significance in various diseases. Current investigations are being pursued, in particular, on the role of probiotics-activated NK cells in promoting the adaptive immune response against pathogens.

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Section: Probioticsmentioning

confidence: 99%

Activation of Natural Killer Cells by Probiotics

Aziz

Bonavida

2016

Forum Immun Dis Ther

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“…According to Kitazawa and Villena [24] the immunobiotic strain Lactobacillus rhamnosus CRL1505 acts by modulating of TLR3-mediated immune response against viral challenge in respiratory tract. Several immunobiotics strains have been screened for their immunomodulatory activities by Ho et al [87] , Lactobacillus paracasei BRAP01 and Lactobacillus acidophilus AD300 associated with higher value of IFN-γ/IL-10 were found to enhance the NK cytotoxicity in human blood. Immunobiotics such as Lactobacillus rhamnosus and Bifidumbacterium lactis HN019 that exhibit anti-inflammatory proprieties could be helpful for patients with COVID-19 [82] .…”

Section: Immunobiotics Intervention In Gut-lung Pathwaysmentioning

confidence: 99%

Probiotics for immunomodulation in prevention against respiratory viral infections with special emphasis on COVID-19

Amrouche

Chikindas

2022

AIMSMICRO

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COVID-19 pandemic is currently causing high mortality and economic crisis, and several drugs-based therapeutic strategies and vaccines are unfortunately used with little efficiency. Therefore, here is an urgent need to provide additives therapies that prevent or improve symptoms in populations infected by SARS-CoV-2 variants. This review aimed to examine relevant scientific information related to SARS-CoV-2 and host antiviral immunity, as well the possible role of probiotics in gut-lung cross talk pathways to promote lung immune response to COVID-19 infection. We searched online databases such as PubMed, Embase, Chinese databases, and selected articles and studies with relevant data reported on COVID-19 and other respiratory viral infections. Recent research highlighted potential immunomodulatory activities of probiotics assessed in animal models and clinical trials. However, the role of probiotics and gut microbiome in COVID-19 management, and approaches with significant understanding in molecular mechanism of probiotic action remain poorly investigated. Clinical investigations as well as animal model studies published have demonstrated that probiotics such as Lactobacillus rhamnosus and Bifidumbacterium lactis HN019, may influence positively not only microbiota balance but also antiviral immunity by improving both innate and adaptive responses and controlling inflammatory reaction in respiratory viral infection. Given the immunological interactions in gut-lung axis and the crucial role of probiotics in modulating immune responses by promoting dendritic cells (DCs) to regulate T cell responses, we hypothesized that application of probiotics may be successful in prevention or treatment of both intestinal disorders and airway diseases in patients with COVID-19.

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“…But with the passage of time, probiotics efficiency seem to decrease, gathering scientist's attention. [76] Oral administration of fermented milk with Lactobacillus helveticus R389 demonstrated immunoregulatory response in breast cancer bearing mice and suggested its use as immune adjuvant therapy to protect against malignancies. [77] Yazdi et al not only reported an increase in inferon (IFN)-γ and IL-2 levels but also shows enhanced NK cell activity in selenium nanoparticles enriched Lactobacillus plantarum-treated mice.…”

Section: Association Of Bacteria With Breast Cancermentioning

confidence: 99%

Anticarcinogenecity of microbiota and probiotics in breast cancer

Malik

Saeed

Baig

et al. 2018

International Journal of Food Properties

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Breast cancer is one of the most important causes of cancer related morbidity and mortality in the world. Along with genetic, environmental factors also play a multifaceted role in the development of disease. Breast contains several bacterial species performing specialized functions. Probiotics, as functional food, play pivotal role against breast cancer development in vivo and in vitro. Current review summarized all the available data related to diet, probiotics, and their association with breast cancer risk along with underlying mechanisms. Presently, it was believed that many of the commercially available probiotic products were safe to use and had some beneficial health effects for the host. Probiotics had a potential to act against breast cancer progression evidenced by many animal model and cell-based experiments. Some probiotics strains may be useful as an adjuvant therapy for breast cancer prevention or treatment, by modulating immune response or breast microbial community. However, large-scale clinical trials and intense research are mandatory to explore probiotics-related metabolic and molecular mechanisms in breast cancer. ARTICLE HISTORY

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Daily Intake of Probiotics with High IFN-γ/IL-10 Ratio Increases the Cytotoxicity of Human Natural Killer Cells: A Personalized Probiotic Approach

Cited by 9 publications

References 29 publications

Activation of Natural Killer Cells by Probiotics

Activation of Natural Killer Cells by Probiotics

Probiotics for immunomodulation in prevention against respiratory viral infections with special emphasis on COVID-19

Anticarcinogenecity of microbiota and probiotics in breast cancer

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