Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: A double-blind, randomized, and placebo-controlled clinical trial

Sawada, Daisuke; Kuwano, Yuki; Tanaka, Hiroki; Hara, Shotaro; Uchiyama, Yoshihide; Sugawara, Toshitaka; Fujiwara, Shigeru; Rokutan, Kazuhito; Nishida, Kensei

doi:10.1016/j.jff.2019.04.022

Cited by 52 publications

(45 citation statements)

References 53 publications

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“…In addition to viable bacteria, studies have been performed using inactivated bacteria. Two studies have investigated the effects of supplementation with inactivated Lactobacillus on mood related measurements [ 119 , 120 ]. A 4-week supplementation period, using heat-inactivated L. gasseri OLL2809, reduced tension-anxiety scores after a 1-h cycle ergometer exercise, compared with baseline scores [ 119 ].…”

Section: Probiotics As a Potential Ergogenic Aid To Enhance Physicmentioning

confidence: 99%

“…A 4-week supplementation period, using heat-inactivated L. gasseri OLL2809, reduced tension-anxiety scores after a 1-h cycle ergometer exercise, compared with baseline scores [ 119 ]. The 12-week administration of heat-inactivated L. gasseri CP2305 significantly decreased scores that measured physical fatigue, anxiety, and depression in male university student-athletes [ 120 ]. Salivary cortisol and chromogranin A serve as biochemical markers for stress.…”

Section: Probiotics As a Potential Ergogenic Aid To Enhance Physicmentioning

confidence: 99%

“…Salivary cortisol and chromogranin A serve as biochemical markers for stress. In the above-mentioned studies, salivary chromogranin A was significantly reduced in the inactivated Lactobacillus group compared with that in the placebo group [ 120 ], whereas no changes in salivary cortisol levels were detected after the intervention period [ 119 , 120 ].…”

Section: Probiotics As a Potential Ergogenic Aid To Enhance Physicmentioning

confidence: 99%

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Gut Microbiota, Probiotics and Physical Performance in Athletes and Physically Active Individuals

et al. 2020

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Among athletes, nutrition plays a key role, supporting training, performance, and post-exercise recovery. Research has primarily focused on the effects of diet in support of an athletic physique; however, the role played by intestinal microbiota has been much neglected. Emerging evidence has shown an association between the intestinal microbiota composition and physical activity, suggesting that modifications in the gut microbiota composition may contribute to physical performance of the host. Probiotics represent a potential means for beneficially influencing the gut microbiota composition/function but can also impact the overall health of the host. In this review, we provide an overview of the existing studies that have examined the reciprocal interactions between physical activity and gut microbiota. We further evaluate the clinical evidence that supports the effects of probiotics on physical performance, post-exercise recovery, and cognitive outcomes among athletes. In addition, we discuss the mechanisms of action through which probiotics affect exercise outcomes. In summary, beneficial microbes, including probiotics, may promote health in athletes and enhance physical performance and exercise capacity. Furthermore, high-quality clinical studies, with adequate power, remain necessary to uncover the roles that are played by gut microbiota populations and probiotics in physical performance and the modes of action behind their potential benefits.

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Section: Probiotics As a Potential Ergogenic Aid To Enhance Physicmentioning

confidence: 99%

Section: Probiotics As a Potential Ergogenic Aid To Enhance Physicmentioning

confidence: 99%

Section: Probiotics As a Potential Ergogenic Aid To Enhance Physicmentioning

confidence: 99%

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Gut Microbiota, Probiotics and Physical Performance in Athletes and Physically Active Individuals

et al. 2020

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“…Research also showed that one of the methods of inactivating probiotic microorganisms is a change in pH to induce cell membrane damage, chemical changes in fundamental components (ATP and DNA), and enzyme inactivation (Almada et al, 2016). In addition, studies pointed to the possibility of using food as a vehicle for delivering inactivated probiotics (Sawada et al, 2016(Sawada et al, , 2019Sugawara et al, 2016;Nishida et al, 2017a). Thus, it is possible that the inactivation of the starter culture due to stomach acidity does not completely eliminate the beneficial health effects of probiotics.…”

Section: Resistance To Low Ph Valuesmentioning

confidence: 99%

Probiotic characterization of a commercial starter culture used in the fermentation of sausages

et al. 2021

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Probiotic starter culture does not only improve the safety and shelf-life of products but also extends health benefits to the consumer. This study investigated the probiotic potential of a commercial starter culture used in the fermentation of meat sausages. The starter culture tested, composed of Lactobacillus sakei, Staphylococcus xylosus, and Staphylococcus carnosus, was evaluated for resistance to antimicrobials, low pH values and bile salts; production of gas and capsules; acidification capacity; and growth after exposure to different pH values, temperatures, and curing salts. The antagonistic capacity was also assessed against Escherichia coli ATCC25922, Salmonella Enteritidis ATCC13076, Vibrio parahaemolyticus, Staphylococcus aureus ATCC43300, Enterococcus faecalis ATCC29212, and Listeria monocytogenes CERELA. The starter culture was susceptible to all tested antimicrobials and strongly inhibited pathogenic strains, with inhibition halos diameters > 30 mm. The culture was resistant to all concentrations of bile salts tested, did not produce gas or capsules, and could grow within a temperature range of 15 °C to 35 °C in saline medium containing healing salts (nitrite/nitrate). Although, the inability of the culture to withstand low pH, indicating intolerance to stomach acidity, limits its use as a live probiotic, beneficial health effects may be derived from the inactivated culture.

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“…Sequencing was performed with an Illumina MiSeq system and MiSeq Reagent Kit v.2 (300 Cycle). Sequence data were analyzed as described previously [36]. In brief, Quantitative Insights Into Microbial Ecology (QIIME) ver.1.8.0 was used for sequence filtering and analysis [37].…”

Section: Analysis Of Fecal Microbiotamentioning

confidence: 99%

Daily Intake of Paraprobiotic Lactobacillus amylovorus CP1563 Improves Pre-Obese Conditions and Affects the Gut Microbial Community in Healthy Pre-Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

Sugawara¹,

Sawada²,

Yanagihara³

et al. 2020

Microorganisms

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Despite the fact that gut microbiota is closely associated with obesity, few studies have focused on the influences of paraprobiotics as food ingredients on both obesity prevention and the gut microbial community. In this study, we evaluated the effects of fragmented Lactobacillus amylovorus CP1563 (CP1563) as a paraprobiotic for obesity prevention and investigated its effects on the gut microbial community in pre-obese subjects. One hundred sixty-nine healthy subjects with a body mass index from 25.0 to 29.9 kg/m2 ingested beverages with or without the fragmented CP1563 containing 10-hydroxyoctadecanoic acid (10-HOA) for 12 weeks. The changes in abdominal, total, visceral, and subcutaneous fatty areas were significantly lower in the CP1563-10-HOA group than in the placebo group at 12 weeks. Furthermore, 16S rRNA gene sequencing of fecal DNA revealed that the changes in the abundances of the genera Roseburia and Lachnospiraceae;g were significantly greater in the CP1563-10-HOA group than in the placebo group, and the changes in the abundances of the genus Collinsella was significantly smaller in the CP1563-10HOA group than in the placebo group. Our results showed that continuous ingestion of the fragmented CP1563 containing 10-HOA reduced abdominal body fat and affected the gut microbial community in pre-obese healthy subjects. Our findings may contribute to the understanding of the relationship between the anti-obesity effect of paraprobiotics and gut microbiota.

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Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: A double-blind, randomized, and placebo-controlled clinical trial

Cited by 52 publications

References 53 publications

Gut Microbiota, Probiotics and Physical Performance in Athletes and Physically Active Individuals

Gut Microbiota, Probiotics and Physical Performance in Athletes and Physically Active Individuals

Probiotic characterization of a commercial starter culture used in the fermentation of sausages

Daily Intake of Paraprobiotic Lactobacillus amylovorus CP1563 Improves Pre-Obese Conditions and Affects the Gut Microbial Community in Healthy Pre-Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

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