Daily intake of isoflavones of &gt;0.07 g associated with endometrial bleeding

Cohain, Judy Slome

doi:10.1111/j.1471-0528.2009.02490.x

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…We acknowledge that it would be useful for clinical practice and public health policy if recommendations could be made on the amount of soy food in the diet most likely to reduce the risk of endocrine‐related gynaecological cancer. We agree with the comments regarding the dose‐related effects of isoflavone on endometrial activity 2 . However, it is the effect of soy extract, mainly isoflavone, that has been analysed in the studies quoted, not whole soy or soy foods.…”

supporting

confidence: 59%

Daily intake of isoflavones of >0.07 g associated with endometrial bleeding

Myung

Yang

et al. 2010

BJOG

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supporting

confidence: 59%

Daily intake of isoflavones of >0.07 g associated with endometrial bleeding

Myung

Yang

et al. 2010

BJOG

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“…There are a few reports of patients with extremely high consumption of soy products and significant nonmalignant uterine pathology 14,15. Lower, but still quite high isoflavone doses (150 mg of isoflavones per day), during a 5-year period have been found to increase endometrial hyperplasia;16 an informal review indicated that more than 70 mg of isoflavones per day may be associated with endometrial bleeding in postmenopausal women 17. However, there is no evidence for a higher risk of endometrial cancer in women with a high dietary soy intake 18,19…”

Section: Introductionmentioning

confidence: 99%

Soy isoflavone intake and the likelihood of ever becoming a mother: the Adventist Health Study-2

Jacobsen¹,

Jaceldo‐Siegl²,

Knutsen³

et al. 2014

IJWH

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ObjectivesAs little is known about the possible relationship between the intake of phytoestrogens and female fertility, we investigated the relationship between soy isoflavone intake and the risk of nulliparity and nulligravidity.MethodsA cross-sectional study of 11,688 North American Adventist women aged 30–50 years old with data regarding childbearing. These women were, as a group, characterized by a high proportion (54%) of vegetarians and a healthy lifestyle with a very low prevalence of smoking and alcohol use.ResultsThe mean isoflavone intake (17.9 mg per day) was very high compared to other Western populations. Only 6% of the women indicated no intake of isoflavones. We found, after adjustment for age, marital status, and educational level, an inverse relationship (P=0.05) between isoflavone intake and the likelihood of ever having become a mother. In women with high (≥40 mg/day) isoflavone intake (12% of this group of women), the adjusted lifetime probability of giving birth to a live child was reduced by approximately 3% (95% CI: 0, 7) compared to women with low (<10 mg/day) intake. No relationships were found between the isoflavone intake and parity or age at first delivery in parous women. A similar inverse relationship (P=0.03) was found between the isoflavone intake and the risk of nulligravidity with a 13% (95% CI: 2, 26) higher risk of never have been pregnant in women with high (≥40 mg/day) isoflavone intake. These relationships were found mainly in women who reported problems becoming pregnant.ConclusionThe findings suggest that a high dietary isoflavone intake may have significant impact on fertility.

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“…On the other hand, consumption of isoflavones in women reproductive age has been linked to dysmenorrhea, endometriosis, and secondary infertility [16, 128]. A high intake of phytoestrogens resulted in dysmenorrhea and persistent sex arousal syndrome in one case-study reported by Amsterdam et al [15].…”

Section: Adverse Effects Of Isoflavones On the Reproductive Performentioning

confidence: 99%

Diverse Effects of Phytoestrogens on the Reproductive Performance: Cow as a Model

Wocławek-Potocka

Mannelli

Boruszewska

et al. 2013

International Journal of Endocrinology

104

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Phytoestrogens, polyphenolic compounds derived from plants, are more and more common constituents of human and animal diets. In most of the cases, these chemicals are much less potent than endogenous estrogens but exert their biological effects via similar mechanisms of action. The most common source of phytoestrogen exposure to humans as well as ruminants is soybean-derived foods that are rich in the isoflavones genistein and daidzein being metabolized in the digestive tract to even more potent metabolites—para-ethyl-phenol and equol. Phytoestrogens have recently come into considerable interest due to the increasing information on their adverse effects in human and animal reproduction, increasing the number of people substituting animal proteins with plant-derived proteins. Finally, the soybean becomes the main source of protein in animal fodder because of an absolute prohibition of bone meal use for animal feeding in 1995 in Europe. The review describes how exposure of soybean-derived phytoestrogens can have adverse effects on reproductive performance in female adults.

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Daily intake of isoflavones of >0.07 g associated with endometrial bleeding

Cited by 3 publications

References 11 publications

Daily intake of isoflavones of >0.07 g associated with endometrial bleeding

Daily intake of isoflavones of >0.07 g associated with endometrial bleeding

Soy isoflavone intake and the likelihood of ever becoming a mother: the Adventist Health Study-2

Diverse Effects of Phytoestrogens on the Reproductive Performance: Cow as a Model

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