Daily Intake of Cod or Salmon for 2 Weeks Decreases the 18:1n‐9/18:0 Ratio and Serum Triacylglycerols in Healthy Subjects

Telle-Hansen, Vibeke H.; Larsen, Laila N.; Høstmark, Arne T.; Molin, Marianne; Dahl, Lisbeth; Almendingen, Kari; Ulven, Stine Marie

doi:10.1007/s11745-011-3637-y

Cited by 42 publications

(55 citation statements)

References 63 publications

(75 reference statements)

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“…The beneficial effects of fish (especially fatty fish) and fish oil intake on lipid concentrations have been reported by others (12,13,(29)(30)(31)(32)(33)(34)(35) . In the present study, in healthy, non-smoking subjects with normal BMI, high intake of fatty fish for 4 weeks resulted in reduced serum TAG and elevated HDL-cholesterol concentrations when compared with high intake of lean meat and higher HDL-cholesterol concentration when compared with lean fish intake.…”

Section: Discussionmentioning

confidence: 61%

“…Numerous studies in overweight, dyslipidaemic, hypertensive, insulin-resistant and/or diabetic subjects have been conducted to investigate the effects of fish intake on serum lipids and glucose regulation (12,13,17,18,(29)(30)(31)(32)(33)(34)(35)47) ; however, no studies on the effect of high fish intake in a group of young, healthy, nonsmoking, normal-weight adults have been published to date. In the present study, we investigated the effects of high intake of lean or fatty fish compared with lean meat for 4 weeks on serum lipids and glucose regulation in healthy, normal-weight adults.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies of fish intake in other populations have shown that a sample size of between ten and fifteen was sufficient to observe a lowering effect of fish intake on serum TAG concentration (29,31,33) . Therefore, as there is no information available about the necessary sample size, we consider the present study to be hypothesis generating rather than hypothesis testing, and the study will constitute a base for sample size calculations for future studies with similar designs.…”

Section: Statistical Analysesmentioning

confidence: 91%

“…Serum fructosamine concentration as a measure of the mean glucose concentration over the last 1-3 weeks (27) was examined. In addition, methylglyoxal (MG) and N ε -(carboxymethyl) lysine (CML) were analysed, as changes in lipid and glucose regulation may affect the production of MG from the glycation process by degradation of glucose, Schiff's bases or from Amadori products such as fructosamine, and the production of CML insulin-resistant and/or diabetic subjects (12)(13)(17)(18)(29)(30)(31)(32)(33)(34)(35)(36)(37) ; however, as no studies on the effect of high fish intake in a group of young, healthy, non-smoking, normal-weight adults have been published, little is known about how fish intake may affect lipid and glucose metabolism in this population. As the choice of preparation methods of fish and meat as well as the choices of side dishes and accessories may explain some of the different health effects from fish consumption compared with meat (38)(39)(40)(41) , participants in the present study were instructed to follow a recipe booklet to prepare fish and lean meat dinners, respectively, with comparable preparation methods and side dishes.…”

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confidence: 99%

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High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

et al. 2016

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The aim of the present study was to examine whether high intake of lean or fatty fish (cod and farmed salmon, respectively) by healthy, normal-weight adults would affect risk factors of type 2 diabetes and CVD when compared with lean meat (chicken). More knowledge is needed concerning the potential health effects of high fish intake (>300 g/week) in normal-weight adults. In this randomised clinical trial, thirty-eight young, healthy, normal-weight participants consumed 750 g/week of lean or fatty fish or lean meat (as control) for 4 weeks at dinner according to provided recipes to ensure similar ways of preparations and choices of side dishes between the groups. Energy and macronutrient intakes at baseline and end point were similar in all groups, and there were no changes in energy and macronutrient intakes within any of the groups during the course of the study. High intake of fatty fish, but not lean fish, significantly reduced TAG and increased HDL-cholesterol concentrations in fasting serum when compared with lean meat intake. When compared with lean fish intake, fatty fish intake increased serum HDL-cholesterol. No differences were observed between lean fish, fatty fish and lean meat groups regarding fasting and postprandial glucose regulation. These findings suggest that high intake of fatty fish, but not of lean fish, could beneficially affect serum concentrations of TAG and HDL-cholesterol, which are CVD risk factors, in healthy, normal-weight adults, when compared with high intake of lean meat.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 91%

mentioning

confidence: 99%

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High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

et al. 2016

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“…Thus, in general, PUFAs like ALA may decrease rather than stimulate stearoyl-CoA desaturase (SCD1) expression and activity [28-32]. From these previous results we might have expected ALA to be inversely - rather than positively - related to the OA/AA and the OA/stearic acid ratios.…”

Section: Discussionmentioning

confidence: 99%

The inverse association between relative abundances of oleic acid and arachidonic acid is related to alpha -linolenic acid

Høstmark

Haug

2014

Lipids Health Dis

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BackgroundMany health effects of oils rich in oleic acid (OA, 18:1 n9) seem to be opposite those of arachidonic acid (AA, 20:4 n6), i.e. concerning cardiovascular risk. In recent studies in humans and in the rat we observed that percentages of OA and AA were inversely related, raising the question of whether the inverse association is a general one, and how it might be explained. In the present work we examine whether percentages of OA and AA are inversely associated in breast muscle lipids of chickens, and whether alpha-linolenic acid (ALA) may be related to the OA/AA ratio.MethodsThe study group consisted of 163 chickens. Breast muscle was collected, and the concentration of fatty acids in muscle lipids was determined using gas chromatography. We studied association between fatty acids using bivariate correlations (Pearson) and linear regression. Synthesis of OA from stearic acid (Stear) was estimated using the OA/Stear ratio, and formation of AA from linoleic acid (LA) was estimated by the AA/LA ratio.ResultsWe found a strong inverse relationship (r = -0.942, p < 0.001; n = 163) between % OA and % AA in breast muscle lipids of the chickens. There was an inverse association (r = -0.887, p < 0.001) between the OA/Stearic acid ratio, estimating Delta9 desaturase, and the AA/LA ratio, estimating desaturases/elongase activities. Furthermore, there was a strong negative association between % AA and the OA/Stearic acid ratio (r = -0.925, p < 0.001), and % OA correlated negatively (r = -0.914, p < 0.001) with the AA/LA ratio. ALA was positively associated (r = 0.956, p < 0.001) with the OA/AA ratio, and this association prevailed when controlling for the other fatty acids. ALA was positively associated (r = 0.857, p < 0.001) with the OA/Stear ratio, but was negatively related (r = -0.827, p < 0.001) to the AA/LA ratio.ConclusionsThe relative abundances of OA and AA that are inversely related in muscle lipids of chickens may be explained by a feedback regulation between the synthesis of OA and AA, and related to ALA, which seems to stimulate formation of OA, and inhibit synthesis of AA, but further studies are required to clarify whether this hypothesis is valid.

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Ground Beef High in Total Fat and Saturated Fatty Acids Decreases X Receptor Signaling Targets in Peripheral Blood Mononuclear Cells of Men and Women

Choi

Gharahmany

Walzem

et al. 2018

Lipids

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We hypothesized that consumption of saturated fatty acids in the form of high-fat ground beef for 5 weeks would depress liver X receptor signaling targets in peripheral blood mononuclear cells (PBMC) and that changes in gene expression would be associated with the corresponding changes in lipoprotein cholesterol (C) concentrations. Older men (n = 5, age 68.0 ± 4.6 years) and postmenopausal women (n = 7, age 60.9 ± 3.1 years) were assigned randomly to consume ground-beef containing 18% total fat (18F) or 25% total fat (25F), five patties per week for 5 weeks with an intervening 4-week washout period. The 25F and 18F ground-beef increased (p < 0.05) the intake of saturated fat, monounsaturated fat, palmitic acid, and stearic acid, but the 25F ground-beef increased only the intake of oleic acid (p < 0.05). The ground-beefs 18F and 25F increased the plasma concentration of palmitic acid (p < 0.05) and decreased the plasma concentrations of arachidonic, eicosapentaenoic, and docosahexaenic acids (p < 0.05). The interventions of 18F and 25F ground-beef decreased very low-density lipoprotein C concentrations and increased particle diameters and low-density lipoprotein (LDL)-I-C and LDL-II-C concentrations (p < 0.05). The ground-beef 25F decreased PBMC mRNA levels for the adenosine triphosphate (ATP) binding cassette A, ATP binding cassette G1, sterol regulatory element binding protein-1, and LDL receptor (LDLR) (p < 0.05). The ground-beef 18F increased mRNA levels for stearoyl-CoA desaturase-1 (p < 0.05). We conclude that the increased LDL particle size and LDL-I-C and LDL-II-C concentrations following the 25F ground-beef intervention may have been caused by decreased hepatic LDLR gene expression.

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Daily Intake of Cod or Salmon for 2 Weeks Decreases the 18:1n‐9/18:0 Ratio and Serum Triacylglycerols in Healthy Subjects

Cited by 42 publications

References 63 publications

High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

The inverse association between relative abundances of oleic acid and arachidonic acid is related to alpha -linolenic acid

Ground Beef High in Total Fat and Saturated Fatty Acids Decreases X Receptor Signaling Targets in Peripheral Blood Mononuclear Cells of Men and Women

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