Daily infusion of melatonin entrains circadian activity rhythms in the diurnal rodent Arvicanthis ansorgei

Slotten, Helge A.; Krekling, Sturla; Sicard, Bruno; Pévet, Paul

doi:10.1016/s0166-4328(01)00411-9

Cited by 36 publications

(16 citation statements)

References 32 publications

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“…The latter substance was the only agent to affect sleep-wake partitioning when given before the light phase suggesting that this action reflects its intrinsic pharmacological actions rather than the chronobiotic properties shared by agomelatine, melatonin, and ramelteon which were inactive when administered at light onset. This "window of sensitivity" for the influence of melatoninergic agents on sleep around dark onset has similarly been reported for their phase-shifting effects in rodents and man (Lewy et al 1992;Van Reeth et al 1997;Slotten et al 2002;Hack et al 2003). It is worth noting that the effects of agomelatine on sleep though significant at 4-7 h after administration, had subsided by the end of the 12-h dark period.…”

Section: Discussionsupporting

confidence: 67%

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture

et al. 2009

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Section: Discussionsupporting

confidence: 67%

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture

et al. 2009

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“…In diurnal species, nocturnal melatonin secretion coincides with the habitual hours of sleep, in contrast to nocturnal animals that are at the peak of their activity while producing melatonin (Zhdanova, 2005). The endogenous role of melatonin may be to enhance types of behaviour normally associated with night in both diurnal and nocturnal species, with the sensitivity window for exogenous melatonin located near the activity/rest transition points (Slotten et al., 2002). Thus, the aforementioned reinforcement of the locomotor rhythm may be due to the incorporation of melatonin and its related indolic compounds into the organism.…”

Section: Discussionmentioning

confidence: 99%

Diets enriched with a Jerte Valley cherry‐based nutraceutical product reinforce nocturnal behaviour in young and old animals of nocturnal (Rattus norvegicus) and diurnal (Streptopelia risoria) chronotypes

Delgado

Terrón

Garrido

et al. 2011

Animal Physiology Nutrition

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The decline in melatonin secretion with age seems to be one of the major reasons for increased sleep disruption in older animals. Previously, we showed that the administration with melatonin or its precursor, tryptophan, improved activity/rest rhythms in aged individuals. Here, it was evaluated the effect of a 10-day consumption of a Jerte Valley cherry-based nutraceutical product (patent no. ES2342141B1), which contains high levels of tryptophan, serotonin and melatonin, on the activity/rest rhythms of young and old rats (Rattus norvegicus) and ringdoves (Streptopelia risoria) as representatives of animals with nocturnal and diurnal habits, respectively, and its possible relationship with the serum levels of melatonin and glucose. Total diurnal and nocturnal activity pulses were logged at control, during, and up to 3 days after the treatment. Melatonin and glucose were measured with ELISA and testing kits respectively. In both young and old rats, the intake of the cherry nutraceutical decreased diurnal activity, whereas nocturnal activity increased. The opposite effect was observed for ringdoves. The treatment increased the circulating levels of melatonin in both species and restored the amplitude of the activity rhythm in the old animals to that of the non-treated young groups. The consumption of a Jerte Valley cherry-based nutraceutical product may help to counteract the impaired activity/rest rhythm found in aged animals.

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“…Previous studies using diverse non‐photic stimuli have also shown entrainment of the free‐running rhythm when a phase relation was established between the entraining stimulus and the transition phases of activity. In some studies the phase relation was established with the activity onset (Glass et al ., 2001; Slotten et al ., 2002) and in other cases it was established with the activity offset (Barrington et al ., 1993), as observed in our study.…”

Section: Discussionmentioning

confidence: 99%

A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats

Mendoza¹,

Ángeles-Castellanos²,

Escobar³

2005

Eur J of Neuroscience

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Food is considered a potent Zeitgeber for peripheral oscillators but not for the suprachiasmatic nucleus (SCN), which is entrained principally by the light-dark cycle. However, when food attains relevant properties in quantity and quality, it can be a potent Zeitgeber even for the SCN. Here we evaluated the entrainment influence of a daily palatable meal, without regular food deprivation, on the circadian rhythm of locomotor activity and the c-Fos and PER-1 protein expression in the SCN. Rats fed ad libitum, in constant darkness, received a palatable meal for 6 weeks starting in the middle of the subjective day. Locomotor activity showed entrainment when the offset of activity coincided with the palatable meal-time. In the SCN, the peak expression of c-Fos was observed at palatable meal-time and PER-1 showed a peak during the onset of subjective night, as predicted according to the behavioural entrained pattern. In addition, c-Fos and PER-1 expression in the paraventricular thalamic nucleus (PVT) showed increased expression at palatable meal-time, while the intergeniculate leaflet did not, suggesting that the PVT may be involved as an input pathway of palatable food-entrainment to the SCN. These results demonstrate that daily access to a palatable meal can entrain the SCN; several stimuli can be implicated in this process, including motivation and arousal.

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Daily infusion of melatonin entrains circadian activity rhythms in the diurnal rodent Arvicanthis ansorgei

Cited by 36 publications

References 32 publications

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture

Diets enriched with a Jerte Valley cherry‐based nutraceutical product reinforce nocturnal behaviour in young and old animals of nocturnal (Rattus norvegicus) and diurnal (Streptopelia risoria) chronotypes

A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats

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