Daily Fungal Cell-Free DNA Testing to Assess Clinical Status during Candida krusei Fungemia
Jo-Anne H. Young,
Xiaoying Liu,
Emma Porter
et al.
Abstract:We present a case of a man immunocompromised due to myelodysplastic syndrome with Candida krusei fungemia who had a rising cell-free DNA (cfDNA) giant magnetoresistance (GMR) signal when tested daily using plasma blood samples. With the rise in GMR signal paralleling the development of skin lesions in this patient, we conclude that cfDNA can be used to indicate uncontrolled infection and thus help monitor response to therapy. This index patient provides evidence that an invasive fungal infection requires both … Show more
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