Daily changes in the blood composition of conscious pigs with catheters in foetal and uterine vessels during late gestation

Randall, G. C. B.

doi:10.1113/jphysiol.1977.sp011978

Cited by 38 publications

(41 citation statements)

References 18 publications

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“…The arterio-venous difference of glucose across the uterus was within the range of those reported earlier in conscious gilts at a similar stage of pregnancy after an overnight fast [1,10,18,44]. Foetal glycaemia was much lower than in the dam which was in agreement with experiments involving sows [1,20,44] and other species [5,26].…”

Section: Glycerolsupporting

confidence: 79%

“…Fasting plasma levels of glucose in the maternal artery were within the same range as those previously reported in sows [1,10,18,20,44,47,48], cows [16,17], ewes [7,36], and rabbits [24]. The arterio-venous difference of glucose across the uterus was within the range of those reported earlier in conscious gilts at a similar stage of pregnancy after an overnight fast [1,10,18,44].…”

Section: Glycerolsupporting

confidence: 75%

“…L -1 and 12.3%, respectively). This is in keeping with the data obtained in foetuses from anaesthetised sows [1,9,47,48] or before meal intake [44]. As a consequence of the hyperglycaemia induced by meal intake in the sow, we observed an elevation of foetal glycaemia, since the placental transfer of glucose depends on the concentration difference of glucose between the mother and the foetus [3].…”

Section: Glycerolsupporting

confidence: 72%

“…Measurements of blood substrate levels in pig foetuses were made either from the umbilical blood during a caesarean operation in anaesthetised animals [1,9,35,[46][47][48][49]59], or from foetuses with catheters implanted in the jugular vein or in the carotid artery [20,44,45]. An attempt of measuring substrate balances across the foetoplacental unit was also performed in the gilt [10].…”

Section: Discussionmentioning

confidence: 99%

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Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

Père

2001

Reprod. Nutr. Dev.

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-Catheters were implanted in 18 gilts at 99 days of pregnancy to study the effects of meal intake on uterine and umbilical uptake of energetic substrates in the conscious pig. Blood samples were withdrawn at 105 days of pregnancy from 10 min before and up to 90 min after feeding of a 2.5-kg meal. Plasma glucose was 2.2 to 2.5 times lower and blood lactate 2 to 3 times higher in the foetus than in the sow. Glucose and lactate increased after the meal. Their umbilical uptake amounted to 0.32 and 0.26 mmol . L -1 , respectively. Fructose was found in large amounts in foetal plasma (4.3 mmol . L -1 ), but it did not seem to be metabolised by the foetus. Meal intake decreased plasma levels of FFA and glycerol in the sows, whereas they increased in the foetuses. A small FFA and glycerol umbilical uptake was recorded (14 and 6 µmol . L -1 , respectively). Most features of the maternofoetal exchanges in the porcine species resemble those of other species, especially ruminants. materno-foetal exchange / energetic substrate / meal intake / pig Résumé -Effets de la prise alimentaire sur les échanges materno-foetaux de substrats énergétiques chez le porc. Des cathéters ont été implantés sur 18 truies à 99 jours de gestation afin d'étudier chez l'animal vigile les effets d'une prise alimentaire sur la capture de substrats énergétiques par l'utérus et le foetus. Des échantillons de sang ont été prélevés à 105 jours de gestation entre 10 min avant et 90 min après la distribution d'un repas de 2,5 kg. La glycémie était 2,2 à 2,5 fois plus faible et la lactatémie 2 à 3 fois plus élevée chez le foetus que chez la mère. Elles augmentaient après le repas. La capture de glucose et de lactate par le foetus était respectivement de 0,32 et 0,26 mmol . L -1 . Les concentrations sanguines de fructose étaient élevées chez le foetus (4,3 mmol . L -1 ), mais ce substrat ne semblait pas métabolisé. La consommation du repas provoquait une diminution des teneurs plasmatiques en AGL et en glycérol des truies alors qu'elles augmentaient chez les foetus. Une faible Reprod. Nutr. Dev. 41 (2001) 285-296 285

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Section: Glycerolsupporting

confidence: 79%

Section: Glycerolsupporting

confidence: 75%

Section: Glycerolsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

Père

2001

Reprod. Nutr. Dev.

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“…Lipids appear to be no more plentiful in the fetal pig. The body fat content of the fetal pig is relatively low at term (Widdowson, 1971) and preliminary measurements of free fatty acid levels in fetal porcine plasma suggest that concentrations are only 5-10% of those seen in the fetal lamb and foal during late gestation (Randall, 1977;Fowden, 1995;Fowden & Silver, 1995a Meschia, 1988) and a positive venous-arterial concentration diflerence in lactate has been observed across the uterine circulation of chronically catheterized pregnant sows in an earlier study (Randall, 1977). In the present study, the weight-specific rate of umbilical lactate uptake was higher and accounted for a greater proportion of the known supply of carbohydrate carbon in the fetal pig (-30 %) than seen in either the fetal foal (-15 %) or lamb (-20 %) at equivalent stages of gestation (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Glucose, lactate and oxygen metabolism in the fetal pig during late gestation

Fowden¹,

Forhead²,

Silver³

et al. 1997

Experimental Physiology

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SUMMARYUsing [U-_4C]glucose tracer, rates of umbilical uptake, utilization and production of glucose, and of CO2 production from glucose carbon, were measured in seven chronically catheterized fetal pigs, when the sow was in the fed state, between 100 and 113 days of gestation (term, 114 + 2 days). At the same time, rates of umbilical 02 and lactate uptake were determined in all seven fetuses by the Fick principle. The mean fetal rates of umbilical glucose uptake, glucose utilization and CO2 production from glucose carbon were 38.4 + 4.2, 41-3 + 5.2 and 126-9 + 12-6 #smol min-' (kg fetal body weight)-', respectively (n = 7). No glucose production was therefore detected in the fetuses. Production of CO2 from glucose carbon accounted for 37-3 + 3.4% (n =7) of the umbilical 02 uptake, which averaged 340 + 13 jumol min-kg-' (n = 7). There was also significant umbilical lactate uptake in the fetal piglets when the sow was in the fed state (32.6 + 10-4 #tsmol min-1 kg-', n = 7, P <0-05). No significant changes in fetal glucose, 0°or lactate metabolism were observed with increasing age towards term. The fetal rates of glucose metabolism and of umbilical uptake of 02 and lactate were not correlated with the fetal blood glucose level. Hence, glucose is used for both oxidative and tfOn-oxidative metabolism in utero and is an important, although not the sole, source of carbon for metabolic processes in the fetal pig during late gestation.

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