Daily and circadian fluctuation in 2-deoxy[ 14 C]-glucose uptake in circadian and visual system structures of the chick brain: effects of exogenous melatonin 1 1Some of these data were previously reported in abstract form: Hansen, E. L.; Cassone, V. M. Circadian fluctuation of 2-deoxy[14C]glucose uptake in the chick brain. Soc. Neurosci. 24:1915; 1998.

Cantwell, Elizabeth L.; Cassone, Vincent M.

doi:10.1016/s0361-9230(01)00753-5

Cited by 18 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…mouse [9], opossum [10], rat, monkey and cat [11]). Also in birds, the visual SCN shows rhythmic 2-DG uptake, peaking during the subjective day (House sparrow [12] and chicken [13]) under both LD and constant darkness (DD) conditions. The rhythm in SCN glucose metabolism is related to SCN function (see [14]) and is in antiphase with rhythms of glucose uptake or utilization observed in other brain regions.…”

Section: Introductionmentioning

confidence: 99%

A 24-Hour Temporal Profile of In Vivo Brain and Heart PET Imaging Reveals a Nocturnal Peak in Brain 18F-Fluorodeoxyglucose Uptake

et al. 2012

View full text Add to dashboard Cite

Using positron emission tomography, we measured in vivo uptake of 18F-fluorodeoxyglucose (FDG) in the brain and heart of C57Bl/6 mice at intervals across a 24-hour light-dark cycle. Our data describe a significant, high amplitude rhythm in FDG uptake throughout the whole brain, peaking at the mid-dark phase of the light-dark cycle, which is the active phase for nocturnal mice. Under these conditions, heart FDG uptake did not vary with time of day, but did show biological variation throughout the 24-hour period for measurements within the same mice. FDG uptake was scanned at different times of day within an individual mouse, and also compared to different times of day between individuals, showing both biological and technical reproducibility of the 24-hour pattern in FDG uptake. Regional analysis of brain FDG uptake revealed especially high amplitude rhythms in the olfactory bulb and cortex, while low amplitude rhythms were observed in the amygdala, brain stem and hypothalamus. Low amplitude 24-hour rhythms in regional FDG uptake may be due to multiple rhythms with different phases in a single brain structure, quenching some of the amplitude. Our data show that the whole brain exhibits significant, high amplitude daily variation in glucose uptake in living mice. Reports applying the 2-deoxy-D[14C]-glucose method for the quantitative determination of the rates of local cerebral glucose utilization indicate only a small number of brain regions exhibiting a day versus night variation in glucose utilization. In contrast, our data show 24-hour patterns in glucose uptake in most of the brain regions examined, including several regions that do not show a difference in glucose utilization. Our data also emphasizes a methodological requirement of controlling for the time of day of scanning FDG uptake in the brain in both clinical and pre-clinical settings, and suggests waveform normalization of FDG measurements at different times of the day.

show abstract

Section: Introductionmentioning

confidence: 99%

A 24-Hour Temporal Profile of In Vivo Brain and Heart PET Imaging Reveals a Nocturnal Peak in Brain 18F-Fluorodeoxyglucose Uptake

et al. 2012

View full text Add to dashboard Cite

show abstract

“…These structures are interconnected through a neural network and share the same population of astrocytes. The vSCN contains receptors for melatonin, and the intake of exogenous melatonin at night can inhibit the rhythmic metabolism and electrical activity in the vSCN [ 33 , 34 , 35 ]. In contrast, during the day, both the mSCN and vSCN are active and synchronised through input from the retinohypothalamic tract (RHT) to the vSCN and possibly extraretinal input to the mSCN.…”

Section: Introductionmentioning

confidence: 99%

Influence of Different Light Spectra on Melatonin Synthesis by the Pineal Gland and Influence on the Immune System in Chickens

Horodincu,

Solcan

2023

Animals

View full text Add to dashboard Cite

It is well known that the pineal gland in birds influences behavioural and physiological functions, including those of the immune system. The purpose of this research is to examine the endocrine–immune correlations between melatonin and immune system activity. Through a description of the immune–pineal axis, we formulated the objective to determine and describe: the development of the pineal gland; how light influences secretory activity; and how melatonin influences the activity of primary and secondary lymphoid organs. The pineal gland has the ability to turn light information into an endocrine signal suitable for the immune system via the membrane receptors Mel1a, Mel1b, and Mel1c, as well as the nuclear receptors RORα, RORβ, and RORγ. We can state the following findings: green monochromatic light (560 nm) increased serum melatonin levels and promoted a stronger humoral and cellular immune response by proliferating B and T lymphocytes; the combination of green and blue monochromatic light (560–480 nm) ameliorated the inflammatory response and protected lymphoid organs from oxidative stress; and red monochromatic light (660 nm) maintained the inflammatory response and promoted the growth of pathogenic bacteria. Melatonin can be considered a potent antioxidant and immunomodulator and is a critical element in the coordination between external light stimulation and the body’s internal response.

show abstract

Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region-specific

et al. 2005

View full text Add to dashboard Cite

Calcium waves among glial cells impact many central nervous system functions, including neural integration and brain metabolism. Here, we characterized the modulatory effects of melatonin, a pineal neurohormone that mediates circadian and seasonal processes, on glial calcium waves derived from different brain regions and species. Diencephalic and telencephalic astrocytes, from both chick and mouse brains, expressed melatonin receptor proteins. Further, using the calcium-sensitive dye Fluo-4, we conducted real-time imaging analyses of calcium waves propagated among mammalian and avian astrocytes. Mouse diencephalic astrocytic calcium waves spread to an area 2-5-fold larger than waves among avian astrocytes and application of 10 nM melatonin caused a 32% increase in the spread of these mammalian calcium waves, similar to the 23% increase observed in chick diencephalic astrocytes. In contrast, melatonin had no effect on calcium waves in either avian or mammalian telencephalic astrocytes. Mouse telencephalic calcium waves radially spread from their initiation site among untreated astrocytes. However, waves meandered among mouse diencephalic astrocytes, taking heterogeneous paths at variable rates of propagation. Brain regional differences in wave propagation were abolished by melatonin, as diencephalic astrocytes acquired more telencephalon-like wave characteristics. Astrocytes cultured from different brain regions, therefore, possess fundamentally disparate mechanisms of calcium wave propagation and responses to melatonin. These results suggest multiple roles for melatonin receptors in the regulation of astroglial function, impacting specific brain regions differentially.

show abstract

Cited by 18 publications

References 43 publications

A 24-Hour Temporal Profile of In Vivo Brain and Heart PET Imaging Reveals a Nocturnal Peak in Brain 18F-Fluorodeoxyglucose Uptake

A 24-Hour Temporal Profile of In Vivo Brain and Heart PET Imaging Reveals a Nocturnal Peak in Brain 18F-Fluorodeoxyglucose Uptake

Influence of Different Light Spectra on Melatonin Synthesis by the Pineal Gland and Influence on the Immune System in Chickens

Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region-specific

Contact Info

Product

Resources

About