Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students

Nishida, Kensei; Sawada, Daisuke; Kuwano, Yuki; Tanaka, Hiroki; Sugawara, Toshitaka; Aoki, Yusuke; Fujiwara, Shigeru; Rokutan, Kazuhito

doi:10.1016/j.jff.2017.06.031

Cited by 69 publications

(63 citation statements)

References 32 publications

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“…Heat-killed L. gasseri decreased expression of leukocytic stress-responsive microRNAs and salivary cortisol levels in stressed individuals (Nishida et al, 2017b). L. gasseri intake also prevented downregulation of EIF2-related genes in IBS patients (Nobutani et al, 2017).…”

Section: Gassericins Gut Microbiota and Parasympathetic Activity Inmentioning

confidence: 94%

“…These studies suggest that L. gasseri confers protection against detrimental effects of stress. Moreover, heat-killed L. gasseri intake promoted parasympathetic nerve activity while improving sleep quality of stressed individuals (Nishida et al, 2017b). In healthy individuals, administration of either live or heat-killed L. gasseri increased their parasympathetic activity (Otomi et al, 2015;Sugawara et al, 2016).…”

Section: Gassericins Gut Microbiota and Parasympathetic Activity Inmentioning

confidence: 99%

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Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

et al. 2020

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The accumulating knowledge of the host-microbiota interplay gives rise to the microbiota-gut-brain (MGB) axis. The MGB axis depicts the interkingdom communication between the gut microbiota and the brain. This communication process involves the endocrine, immune and neurotransmitters systems. Dysfunction of these systems, along with the presence of gut dysbiosis, have been detected among clinically depressed patients. This implicates the involvement of a maladaptive MGB axis in the pathophysiology of depression. Depression refers to symptoms that characterize major depressive disorder (MDD), a mood disorder with a disease burden that rivals that of heart diseases. The use of probiotics to treat depression has gained attention in recent years, as evidenced by increasing numbers of animal and human studies that have supported the antidepressive efficacy of probiotics. Physiological changes observed in these studies allow for the elucidation of probiotics antidepressive mechanisms, which ultimately aim to restore proper functioning of the MGB axis. However, the understanding of mechanisms does not yet complete the endeavor in applying probiotics to treat MDD. Other challenges remain which include the heterogeneous nature of both the gut microbiota composition and depressive symptoms in the clinical setting. Nevertheless, probiotics offer some advantages over standard pharmaceutical antidepressants, in terms of residual symptoms, side effects and stigma involved. This review outlines antidepressive mechanisms of probiotics based on the currently available literature and discusses therapeutic potentials of probiotics for depression.

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Section: Gassericins Gut Microbiota and Parasympathetic Activity Inmentioning

confidence: 94%

Section: Gassericins Gut Microbiota and Parasympathetic Activity Inmentioning

confidence: 99%

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

et al. 2020

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“…In addition, the intervention improved some indicators of sleep quality [16] and certain cold-like and gastrointestinal symptoms, among others [14,15], and affected serotonin metabolism [14]. Similarly, the administration of heat-inactivated Lactobacillus gasseri strain CP2305 to medical students preparing to take an examination improved sleep quality, prevented the increase of salivary cortisol, and affected stress-responsive microRNA expression [17]. Importantly, supplementation of a probiotic mixture containing Lactobacillus and Bifidobacterium exhibited stress-related increase in working memory [18], which could hypothetically enhance academic examination performance [1,19].…”

Section: Introductionmentioning

confidence: 98%

Effect of Supplementation with Saccharomyces Boulardii on Academic Examination Performance and Related Stress in Healthy Medical Students: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2020

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In recent years, bacterial probiotic dietary supplementation has emerged as a promising way to improve cognition and to alleviate stress and anxiety; however, yeast probiotics have not been tested. The aim of the present study was to determine whether 30-day supplementation with Saccharomyces boulardii enhances academic performance under stress and affects stress markers. The trial was retrospectively registered at clinicaltrials.gov (NCT03427515). Healthy medical students were randomized to supplement their diet with Saccharomyces boulardii CNCM I-1079 or placebo before sitting for an academic examination, which served as a model of stress. The grades of a final examination adjusted to subject knowledge tested in non-stressful conditions was used as a primary outcome measure. Psychometrically evaluated state anxiety, cortisol and metanephrine salivary levels, and pulse rate were tested at a non-stressful time point before the intervention as well as just before the stressor. Fifty enrolled participants (22.6 ± 1.4 years of age, 19 males) completed the trial in the Saccharomyces and placebo arms. Supplementation with Saccharomyces did not significantly modify examination performance or increase in state anxiety, salivary cortisol, and metanephrine. However, the intervention resulted in higher increase in pulse rate under stress as compared to placebo by 10.4 (95% CI 4.2–16.6) min−1 (p = 0.0018), and the effect positively correlated with increase in salivary metanephrine (Pearson’s r = 0.35, 95% CI 0.09–0.58, p = 0.012). An intention-to-treat analysis was in line with the per-protocol one. In conclusion, supplementation with Saccharomyces boulardii CNCM I-1079 appears largely ineffective in improving academic performance under stress and in alleviating some stress markers, but it seems to increase pulse rate under stress, which may hypothetically reflect enhanced sympathoadrenal activity.

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“…Research also showed that one of the methods of inactivating probiotic microorganisms is a change in pH to induce cell membrane damage, chemical changes in fundamental components (ATP and DNA), and enzyme inactivation (Almada et al, 2016). In addition, studies pointed to the possibility of using food as a vehicle for delivering inactivated probiotics (Sawada et al, 2016(Sawada et al, , 2019Sugawara et al, 2016;Nishida et al, 2017a). Thus, it is possible that the inactivation of the starter culture due to stomach acidity does not completely eliminate the beneficial health effects of probiotics.…”

Section: Resistance To Low Ph Valuesmentioning

confidence: 99%

Probiotic characterization of a commercial starter culture used in the fermentation of sausages

et al. 2021

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Probiotic starter culture does not only improve the safety and shelf-life of products but also extends health benefits to the consumer. This study investigated the probiotic potential of a commercial starter culture used in the fermentation of meat sausages. The starter culture tested, composed of Lactobacillus sakei, Staphylococcus xylosus, and Staphylococcus carnosus, was evaluated for resistance to antimicrobials, low pH values and bile salts; production of gas and capsules; acidification capacity; and growth after exposure to different pH values, temperatures, and curing salts. The antagonistic capacity was also assessed against Escherichia coli ATCC25922, Salmonella Enteritidis ATCC13076, Vibrio parahaemolyticus, Staphylococcus aureus ATCC43300, Enterococcus faecalis ATCC29212, and Listeria monocytogenes CERELA. The starter culture was susceptible to all tested antimicrobials and strongly inhibited pathogenic strains, with inhibition halos diameters > 30 mm. The culture was resistant to all concentrations of bile salts tested, did not produce gas or capsules, and could grow within a temperature range of 15 °C to 35 °C in saline medium containing healing salts (nitrite/nitrate). Although, the inability of the culture to withstand low pH, indicating intolerance to stomach acidity, limits its use as a live probiotic, beneficial health effects may be derived from the inactivated culture.

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Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students

Cited by 69 publications

References 32 publications

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

Effect of Supplementation with Saccharomyces Boulardii on Academic Examination Performance and Related Stress in Healthy Medical Students: A Randomized, Double-Blind, Placebo-Controlled Trial

Probiotic characterization of a commercial starter culture used in the fermentation of sausages

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