DaiCee: A database for anti-cancer compounds with targets and side effect profiles

Abstract

Identification of the toxicity of compounds is more crucial before entering clinical trials. Awareness of physiochemical properties, possible targets and side effects has become a major public health issue to reduce risks. Experimental determination of analyzing the physiochemical properties of a drug, their interaction with specific receptors and identifying their side-effects remain challenging is time consuming and costly. We describe a manually compiled database named DaiCee database, which contains 2100 anticancer drugs with information on their physiochemical properties, targets of action and side effects. It includes both synthetic and herbal anti-cancer compounds. It allows the search for SMILES notation, Lipinski’s and ADME/T properties, targets and side effect profiles of the drugs. This helps to identify drugs with effective anticancer properties, their toxic nature, drug-likeness for in-vitro and in-vivo experiments. It also used for comparative analysis and screening of effective anticancer drugs using available data for compounds in the database. The database will be updated regularly to provide the users with latest information. The database is available at the URL http://www.hccbif.org/usersearch.php

The bright side of chemistry: Exploring synthetic peptide‐based anticancer vaccines

“…3 Different treatment strategies like surgery, radiotherapy, and chemotherapy offer valuable options for anticancer therapies. [4][5][6][7][8][9] While surgery is often regarded as the most beneficial choice for enhancing a patient's life expectancy and quality, particularly in cases of solid tumors, a considerable number of these tumors are already deemed inoperable at the time of diagnosis. Chemotherapy is a versatile instrument in cancer treatment, and its application depends on the type of cancer, its stage, and the overall treatment plan.…”

“…To date, tumors are classified by their primary site of origin into various types, including lung, prostate, colorectal, stomach, breast, cervical, and thyroid cancers 3 . Different treatment strategies like surgery, radiotherapy, and chemotherapy offer valuable options for anticancer therapies 4–9 . While surgery is often regarded as the most beneficial choice for enhancing a patient's life expectancy and quality, particularly in cases of solid tumors, a considerable number of these tumors are already deemed inoperable at the time of diagnosis.…”

A Novel Anticancer Peptide Derived from Bryopsis plumosa Regulates Proliferation and Invasion in Non-Small Cell Lung Cancer Cells

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