Daemonorops draco Blume Induces Apoptosis Against Acute Myeloid Leukemia Cells via Regulation of the miR-216b/c-Jun

Park, Moon Nyeo; Jeon, Hee Won; Rahman, Md. Ataur; Park, Se Sun; Jeong, Se Yun; Kim, Ki‐Hyun; Kim, Sung Hoon; Kim, Woojin; Kim, Bonglee

doi:10.3389/fonc.2022.808174

Cited by 6 publications

(4 citation statements)

References 87 publications

(99 reference statements)

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“…Furthermore, the anticancer effect shown in several types of cancer cells was facilitated through CHOP-dependent apoptosis [54,59,[84][85][86][87][88][89]. The CHOP protein, which is linked to endoplasmic reticulum (ER) stress, plays a pivotal role in initiating apoptosis in cells under sustained intracellular stress caused by the generation of ROS [54,61].To further authenticate, it was established that the administration of a reactive oxygen species (ROS) inhibitor (NAC) efficiently suppressed the generation of ROS.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic Effect of Gallic Acid via Regulation of p-p38 and ER Stress in PANC-1 and MIA PaCa-2 Cells Pancreatic Cancer Cells

Kim,

Choi,

Park

et al. 2023

IJMS

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Pancreatic cancer (PC) is currently recognized as the seventh most prevalent cause of cancer-related mortality among individuals of both genders. It is projected that a significant number of individuals will succumb to this disease in the forthcoming years. Extensive research and validation have been conducted on both gemcitabine and 5-fluorouracil as viable therapeutic options for PC. Nevertheless, despite concerted attempts to enhance treatment outcomes, PC continues to pose significant challenges in terms of achieving effective treatment alone through chemotherapy. Gallic acid, an endogenous chemical present in various botanical preparations, has attracted considerable attention due to its potential as an anticancer agent. The results of the study demonstrated that gallic acid exerted a decline in cell viability that was dependent on its concentration. Furthermore, it efficiently suppressed cell proliferation in PC cells. This study observed a positive correlation between gallic acid and the production of reactive oxygen species (ROS). Additionally, it confirmed the upregulation of proteins associated with the protein kinase-like endoplasmic reticulum kinase (PERK) pathway, which is one of the pathways involved in endoplasmic reticulum (ER) stress. Moreover, the administration of gallic acid resulted in verified alterations in the transmission of mitogen-activated protein kinase (MAPK) signals. Notably, an elevation in the levels of p-p38, which represents the phosphorylated state of p38 MAPK was detected. The scavenger of reactive oxygen species (ROS), N-Acetyl-L-cysteine (NAC), has shown inhibitory effects on phosphorylated p38 (p-p38), whereas the p38 inhibitor SB203580 inhibited C/EBP homologous protein (CHOP). In both instances, the levels of PARP have been successfully reinstated. In other words, the study discovered a correlation between endoplasmic reticulum stress and the p38 signaling pathway. Consequently, gallic acid induces the activation of both the p38 pathway and the ER stress pathway through the generation of ROS, ultimately resulting in apoptosis. The outcomes of this study provide compelling evidence to support the notion that gallic acid possesses considerable promise as a viable therapeutic intervention for pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

Apoptotic Effect of Gallic Acid via Regulation of p-p38 and ER Stress in PANC-1 and MIA PaCa-2 Cells Pancreatic Cancer Cells

Kim,

Choi,

Park

et al. 2023

IJMS

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“…Dragon's blood, also called Daemonorops draco Blume (DD), is a traditional Korean medicine used to relieve pain from wound infections. DD increased ROS generation and miR-216b expression while downregulating c-Jun [192]. Casticin has anti-inflammatory and anti-carcinogenic properties that are used in traditional herbal medicine.…”

Section: Herbal Treatment Strategies For Aml Employing System Biologymentioning

confidence: 99%

“…Leonurus japonicus Houttuyn (LJH) miR-19a-3p/PTEN (THP-1, U937) [191] Daemonorops draco Blume (DD) miR-216b/c-Jun (THP-1, U937) [192] Casticin miR-338-3/RUNX1 PI3K-AKT (HL-60, HS-5) [193] Arsenic-Containing Qinghuang (QHP) AKT1, MAPK1, MAPK3, PIK3CG CASP3, CASP9, TNF, TGFB1, MAPK8, and TP53 (KG1-a, HL-60) NF-kB, p53, ROS [194] Flavonoid Parthenolide (PTL) primary AML cells, bcCML cells, normal bone marrow (BM), and umbilical cord blood (CB) cells from the National Disease Research Interchange (NDRI) [195] Quercetin caspase-8, caspase-9, and caspase-3, cleaved PARP, and depolarized mitochondria via ERK-mediated apoptosis pathway (THP-1, MV4-11, U937, HL-60 cells) [196] 1-Cinnamoyltrichilinin p38 pathway [197] Alkaloid Curine Cell cycle arrest (HL-60 cells) [198] Carotenoid Indicaxanthin NOX-4, NF-κB, redox balance, Ca homeostasis, mitochondrial damage (THP-1 cells) [200] Fucoxanthin cleaved caspases-3, -7, PARP, Bcl-xL, ROS (HL-60 cells) [201] Isolancifolide cytochrome c, Smac/DIABLO, and cleaved caspases-8, -3, and PARP (HL-60 cells) [202] Phenolics Curcumin ERK/JNK/Jun cascade (THP-1 cells) [204]…”

Section: Flavonoidmentioning

confidence: 99%

The Therapeutic Potential of a Strategy to Prevent Acute Myeloid Leukemia Stem Cell Reprogramming in Older Patients

Park

2023

IJMS

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Acute myeloid leukemia (AML) is the most common and incurable leukemia subtype. Despite extensive research into the disease’s intricate molecular mechanisms, effective treatments or expanded diagnostic or prognostic markers for AML have not yet been identified. The morphological, immunophenotypic, cytogenetic, biomolecular, and clinical characteristics of AML patients are extensive and complex. Leukemia stem cells (LSCs) consist of hematopoietic stem cells (HSCs) and cancer cells transformed by a complex, finely-tuned interaction that causes the complexity of AML. Microenvironmental regulation of LSCs dormancy and the diagnostic and therapeutic implications for identifying and targeting LSCs due to their significance in the pathogenesis of AML are discussed in this review. It is essential to perceive the relationship between the niche for LSCs and HSCs, which together cause the progression of AML. Notably, methylation is a well-known epigenetic change that is significant in AML, and our data also reveal that microRNAs are a unique factor for LSCs. Multiple-targeted approaches to reduce the risk of epigenetic factors, such as the administration of natural compounds for the elimination of local LSCs, may prevent potentially fatal relapses. Furthermore, the survival analysis of overlapping genes revealed that specific targets had significant effects on the survival and prognosis of patients. We predict that the multiple-targeted effects of herbal products on epigenetic modification are governed by different mechanisms in AML and could prevent potentially fatal relapses. Thus, these strategies can facilitate the incorporation of herbal medicine and natural compounds into the advanced drug discovery and development processes achievable with Network Pharmacology research.

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“…Dragon's blood, also called Daemonorops draco Blume (DD), is a traditional Korean medicine used to relieve pain from wound infections. DD increased ROS generation and miR-216b expression, while downregulating c-Jun [194]. Casticin has anti-inflammatory and anticarcinogenic properties that are used in traditional herbal medicine.…”

Section: Herbal Treatment Strategies For Aml Employing System Biologymentioning

confidence: 99%

The Therapeutic Potential of Herbal Remedies To Prevent Leuke-Mia Stem Cell Reprogramming in Acute Myeloid Leukemia

Park¹

2023

Preprint

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Acute myeloid leukemia (AML) is the most common and incurable leukemia subtype. Despite extensive research into the disease's intricate molecular mechanisms, AML have not yet identified effective treatments or expanded diagnostic or prognostic markers. The morphological, immunophenotypic, cytogenetic, biomolecular, and clinical characteristics of AML patients are extensive and complex. Leukemia stem cells (LSC) consist of hematopoietic stem cells (HSC) and cancer cells transformed by the complex, finely-tuned interaction that causes the complexity of AML. Microenvironmental regulation of LSC dormancy, its diagnostic and therapeutic implications for identifying and targeting LSCs due to their significance in the pathogenesis of AML were discussed in this review. It is essential to perceive the relationship between the niche for LSCs and HSC, which together cause the progression of AML. Notably, methylation is a well-known epigenetic change that is significant in AML, and our data also reveals that microRNAs are a unique factor for LSC. Furthermore, multiple-targeted approaches to reduce the risk of epigenetic factors, such as the administration of natural compounds for the elimination of local LSC, may prevent potentially fatal relapses. Furthermore, the survival analysis of overlapping genes revealed that specific targets had significant effects on the survival and prognosis of patients. We predicted that the multiple-targeted effects of herbal products on epigenetic modification are governed by different mechanisms in AML and prevent potentially fatal relapses. Thus, these strategies can facilitate the incorporation of herbal medicine and natural compounds into the advanced drug discovery and development processes enabled achievable by Network Pharmacology research.

show abstract

Daemonorops draco Blume Induces Apoptosis Against Acute Myeloid Leukemia Cells via Regulation of the miR-216b/c-Jun

Cited by 6 publications

References 87 publications

Apoptotic Effect of Gallic Acid via Regulation of p-p38 and ER Stress in PANC-1 and MIA PaCa-2 Cells Pancreatic Cancer Cells

Apoptotic Effect of Gallic Acid via Regulation of p-p38 and ER Stress in PANC-1 and MIA PaCa-2 Cells Pancreatic Cancer Cells

The Therapeutic Potential of a Strategy to Prevent Acute Myeloid Leukemia Stem Cell Reprogramming in Older Patients

The Therapeutic Potential of Herbal Remedies To Prevent Leuke-Mia Stem Cell Reprogramming in Acute Myeloid Leukemia

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