2017
DOI: 10.1007/s12035-017-0409-6
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Dad’s Snoring May Have Left Molecular Scars in Your DNA: the Emerging Role of Epigenetics in Sleep Disorders

Abstract: The sleep-wake cycle is a biological phenomena under the orchestration of neurophysiological, neurochemical, neuroanatomical, and genetical mechanisms. Moreover, homeostatic and circadian processes participate in the regulation of sleep across the light-dark period. Further complexity of the understanding of the genesis of sleep engages disturbances which have been characterized and classified in a variety of sleep-wake cycle disorders. The most prominent sleep alterations include insomnia as well as excessive… Show more

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Cited by 11 publications
(11 citation statements)
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“…Although limited evidence is available in regards the role of histone methylation/demethylation activity in neurobiological phenomena, our studies extend these data to suggest that nuclear elements could induce sleep and neurochemical modulation (Duan et al, 2016; Gaine et al, 2018; Morales-Lara et al, 2018; Shalaby et al, 2018). Following this idea, we have developed a conceptual framework that suggests that manipulation of histone methylation/demethylation activity could engage sleep-related genes: chromatin organization by histone methylation/demethylation, implies the modulation of the activity of large numbers of genes (MacPherson et al, 2018; Lamadema et al, 2019; Ricketts et al, 2019), including those that have been associated with sleep control (Wang and Liu, 2016; Tomita et al, 2017; Kim et al, 2018).…”
Section: Discussionsupporting
confidence: 60%
“…Although limited evidence is available in regards the role of histone methylation/demethylation activity in neurobiological phenomena, our studies extend these data to suggest that nuclear elements could induce sleep and neurochemical modulation (Duan et al, 2016; Gaine et al, 2018; Morales-Lara et al, 2018; Shalaby et al, 2018). Following this idea, we have developed a conceptual framework that suggests that manipulation of histone methylation/demethylation activity could engage sleep-related genes: chromatin organization by histone methylation/demethylation, implies the modulation of the activity of large numbers of genes (MacPherson et al, 2018; Lamadema et al, 2019; Ricketts et al, 2019), including those that have been associated with sleep control (Wang and Liu, 2016; Tomita et al, 2017; Kim et al, 2018).…”
Section: Discussionsupporting
confidence: 60%
“…Besides the tremendous advances in cancer epigenetics, current research endeavors are ongoing towards the understanding of the epigenetic phenomena in the physiopathology of other complex diseases, and their potential applications in diagnostics and therapeutics. In particular, it is now accepted that epigenetic phenomena are key contributors in the homeostatic as well as circadian control of sleep [ 48 ]. A growing corpus of evidence demonstrates the fundamental role of epigenetic dysfunction in sleep apnea [ 49 ], insomnia [ 50 ] and sleep deprivation [ 51 ] and their comorbidities.…”
Section: The Potential Contributions Of Epigenetics In Precision Sleep Medicinementioning
confidence: 99%
“…These observation shows connection between circadian (sleep) dysregulations and epigenetics changes that are involved in the development of T2DM. Notably, epigenetic modifications can be inherited [137]. Factors like particulate air pollution [77], preeclampsia [138] or maternal circadian disruption [139] influence DNA methylation pattern in new-born and may have an impact on its health condition.…”
Section: Conclusion and Possible Treatmentsmentioning
confidence: 99%