Dacrymenone and VM 3298-2 - New Antibiotics with Antibacterial and Antifungal Activity

Mierau, Viktor; Anke, Timm; Sterner, Olov

doi:10.1515/znc-2003-7-816

Cited by 9 publications

(4 citation statements)

References 1 publication

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“…Glykenins were originally isolated from an unidentified basidiomycete [23]. After that, glykenin IV A was isolated from Dacrymyces stillatus [24]. We isolated here a new glykenin-related compound, F-19848 A, from a different Dacrymyces strain.…”

Section: Biological Activitiesmentioning

confidence: 93%

F-19848 A, a Novel Inhibitor of Hyaluronic Acid Binding to Cellular Receptor CD44

et al. 2007

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In the course of our screening for inhibitors of hyaluronic acid (HA) binding to cellular receptor CD44, a novel inhibitor, F-19848 A, was isolated from the cultured broth of the fungus strain Dacrymyces sp. SANK 20204. This compound inhibited the binding of CD44 and HA with an IC 50 value of 23.5 m M and CD44-dependent HA degradation was inhibited with an IC 50 value of 98.6 mM in a cell-based assay. The structure was elucidated by physicochemical properties, analysis of spectral data, and decomposition experiments.

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Section: Biological Activitiesmentioning

confidence: 93%

F-19848 A, a Novel Inhibitor of Hyaluronic Acid Binding to Cellular Receptor CD44

et al. 2007

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“…Inhibition of DNA, RNA, and protein synthesis was tested with N. coryli and HL 60 cells as described previously [12,13]. Inhibition of oxygen uptake (respiration) in Bacillus subtilis and Nematospora coryli was measured with an oxygen electrode (pO 2 analysator R55, Bachofer, Reutlingen).…”

Section: Biological Activitiesmentioning

confidence: 99%

New Aromatic Nitro Compounds from Salegentibacter sp. T436, an Arctic Sea Ice Bacterium: Taxonomy, Fermentation, Isolation and Biological Activities

et al. 2007

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Nineteen aromatic nitro compounds were isolated from the culture broth of an Artic sea ice bacterium. Four of these compounds are new and six compounds are reported from a natural source for the first time. The new natural products showed weak antimicrobial and cytotoxic activities. 2-Nitro-4-(2Ј-nitroethenyl)-phenol was the most potent antimicrobial and cytotoxic substance. Some of the compounds exhibit plant growth modulating activities. Based on its biochemical properties and the 16S rRNA gene sequence, the producing strain can be described as a distinct species within the genus Salegentibacter.

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“…The fungal strains used were: Mucor miehei TU 284, Nematospora corily ATCC 10647, Paecilomyces variotii ETH 114646, and Penicillium notatum. Extracts that showed the highest activity against one or more test microorganisms in the primary assay were considered potentially active and selected to determine a minimal inhibitory concentration (MIC) value against B. brevis, P. notatum, and P. variotii with the serial dilution assays [18]. Different concentrations of extracts were placed in tubes before the diluted bacterial and fungal spore suspensions (2 mL) were added.…”

Section: Evaluation Of Antimicrobial Activitymentioning

confidence: 99%

Antimicrobial Activity of Submerged Cultures of Chilean Basidiomycetes

et al. 2010

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This study is part of a screening program aimed at searching for bioactive metabolites from Chilean basidiomycetes. Submerged cultivation of fungal mycelia in liquid media was evaluated for antimicrobial activity. A total of 148 strains were obtained in vitro. The extracts produced from submerged cultures were evaluated against bacteria and fungi. In the primary antimicrobial assay, approximately 60% of the extracts presented positive biological activity. The highest frequencies of active strains were from the orders Agaricales (31.0%), Polyporales (20.6%), Sterales (18.3%), Boletales (11.4%), and Cortinariales (9.1%). Antifungal activity was more pronounced than antibacterial activity. Twelve extracts that exhibited strong antimicrobial activity showed minimum inhibitory concentration (MIC) values of 50 µL/mL against Bacillus brevis and 25∼50 µL/mL against Penicillium notatum and Paecilomyces variotii. The biological activity of some strains did not vary considerably, regardless of the substrate or collection site whereas, for others, it showed marked variations. Differences in antimicrobial activities observed in the different fungal genera suggested that the ability to produce bioactive compounds is not homogenously distributed among basidiomycetes. The information obtained from this study reveals that Chilean basidiomycetes are able to generate small and/or large variations in the normal pathway of compounds production. Thus, it is necessary to evaluate this biological and chemical wealth, which could be an unsuspected reservoir of new and potentially useful molecules.

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Dacrymenone and VM 3298-2 - New Antibiotics with Antibacterial and Antifungal Activity

Cited by 9 publications

References 1 publication

F-19848 A, a Novel Inhibitor of Hyaluronic Acid Binding to Cellular Receptor CD44

F-19848 A, a Novel Inhibitor of Hyaluronic Acid Binding to Cellular Receptor CD44

New Aromatic Nitro Compounds from Salegentibacter sp. T436, an Arctic Sea Ice Bacterium: Taxonomy, Fermentation, Isolation and Biological Activities

Antimicrobial Activity of Submerged Cultures of Chilean Basidiomycetes

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