Dacarbazine-primed carbon quantum dots coated with breast cancer cell-derived exosomes for improved breast cancer therapy

Engineering exosomes to reshape the immune microenvironment in breast cancer: Molecular insights and therapeutic opportunities

“…The utilization of dacarbazine pre‐treatment enhances therapeutic efficacy, while the source of exosomes imparts specificity to the treatment. 43 However, it is essential to note potential drawbacks, such as the possible toxicity associated with synthesized carbon quantum dots and the complexity of the preparation process, which may pose challenges for clinical applications. 44 Therefore, a comprehensive evaluation of safety, efficacy, and the resolution of potential technical challenges are crucial for advancing the development of this therapeutic strategy.…”

Targeted exosome-based nanoplatform for new-generation therapeutic strategies

“…For example, dacarbazine-loaded carbon quantum dots upon coating exosome could enhance the antitumor efficacy. Exosomes not only improved the integrity of nanomedicine, but also facilitated the targeted delivery to cancer cells via heparan sulfate proteoglycan receptors [188]. In another study, exosome coating endowed nanogel (loaded with pituitary adenylate cyclase-activating polypeptide and estrogen) with good stability and the ability to cross the blood-brain barrier, ameliorating perimenopausal depression by reducing proinflammatory cytokine and oxidant stress, and promoting neural synaptic plasticity [189].…”

Quantum Dot Research in Breast Cancer: Challenges and Prospects

“…Dacarbazine was encapsulated within fucose-based carbon quantum dots, which were subsequently coated with exosomes derived from breast cancer cells. This strategy aimed to enhance the targeted delivery and therapeutic efficacy of the chemotherapeutic agent, leading to an improved antitumor targeting and efficacy with controlled drug release and cellular uptake, demonstrating a sophisticated approach to cancer treatment [98].…”

“…Therapeutic Applications and Mechanisms: Exploring therapeutic applications involves evaluating drug delivery systems, therapeutic efficacy, and studying underlying mechanisms like apoptosis, and photothermal and photodynamic effects [1,3,6,7,10,16,17,25,96,115]. Mechanistic studies are critical as they delve into cellular responses, such as cell cycle progression and apoptosis, revealing how QDs influence biological processes at the molecular level [10,45,95,98,114,115].…”

“…Additionally, QDs have facilitated the development of targeted cancer treatments, improving the delivery and efficacy of chemotherapeutic agents such as doxorubicin and tamoxifen. They have also been employed in novel therapeutic strategies, including photodynamic and photothermal therapies, demonstrating improved targeting and efficacy, and reducing potential side effects in breast cancer treatment [5,16,17,53,88,91,92,98,100].…”