Dacarbazine induced human liver damage

Hepatic Veno-occlusive Disease (Sinusoidal Obstruction Syndrome) After Hematopoietic Stem Cell Transplantation

“…3,4 VOD developing after allogeneic stem cell transplantation was first described in 1979, 5,6 and stem cell transplantation has since become the most common cause of VOD in the Western Hemisphere. [7][8][9] However, VOD also has been described in association with chemotherapeutic agents such as actinomycin D, 10 mithramycin, dacarbazine, 11 cytosine arabinoside, and 6-thioguanine 12 used at conventional doses and with long-term use of the immunosuppressive agent azathioprine. 13 More recently, VOD has been seen after therapy for acute myelogenous leukemia with the PAI = plasminogen activator inhibitor; PG = prostaglandin; TBI = total body irradiation; tPA = tissue-type plasminogen activator; VOD = veno-occlusive disease monoclonal anti-CD33 antibody gemtuzumab ozogamicin (Mylotarg).…”