Dabsylated Bradykinin Is Cleaved by Snake Venom Proteases from Echis ocellatus
Julius Abiola,
Anna Maria Berg,
Olapeju Aiyelaagbe
et al.
Abstract:The vasoactive peptide bradykinin (BK) is an important member of the renin–angiotensin system. Its discovery is tightly interwoven with snake venom research, because it was first detected in plasma following the addition of viper venom. While the fact that venoms liberate BK from a serum globulin fraction is well described, its destruction by the venom has largely gone unnoticed. Here, BK was found to be cleaved by snake venom metalloproteinases in the venom of Echis ocellatus, one of the deadliest snakes, whi… Show more
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