DABCO Catalyzed Green and Efficient Synthesis of 2-Amino-4H-Pyrans and Their Biological Evaluation as Antimicrobial and Anticancer Agents

Abstract

The present method is simple, rapid, and most efficient green protocol for the synthesis of 2-amino-4H-pyran derivatives using highly inexpensive and easily available DABCO as an efficient catalyst under grinding and solvent free condition at room temperature.

Recyclable mesalamine-functionalized magnetic nanoparticles (mesalamine/GPTMS@SiO2@Fe3O4) for tandem Knoevenagel–Michael cyclocondensation: grinding technique for the synthesis of biologically active 2-amino-4H-benzo[b]pyran derivatives

“…Given the importance of these compounds, many catalyst have been developed for the synthesis of 2-amino-3-cyano-4 H -pyran such as Fe 3 O 4 @SiO 2 @GPTMS@guanidine, 31 Fe 3 O 4 @GA@IG, 32 Fe 3 O 4 @SiO 2 –NH 2 @TCT–guanidine, 33 boron nitride@Fe 3 O 4 , 34 montmorillonite, 35 GO-Fc@Fe 3 O 4 , 36 [EMIM][OH], 37 nano-SnO 2 , 38 sodium alginate, 39 [PEG(mim) 2 ][OH] 2 , 40 iodine, 41 cesium fluoride, 42 MNPs@Cu, 43 DABCO, 44 CeCl 3 ·7H 2 O, 45 Fe 3 O 4 @GA@IG, 46 EDA/(CH 2 ) 3 @SiO 2 @Fe 3 O 4 , 47 NH 4 H 2 PO 4 /Al 2 O 3 , 48 NiFe 2 O 4 @SiO 2 @H 14 [NaP 5 W 30 O 110 ], 49 Ag/Fe 3 O 4 @starch, 50 per-6-NH 2 –β-CD, 51 Fe 3 O 4 @NH 2 @TCT@HOProCu, 52 and molecular iodine. 53 Despite some advantages of the reported methods, some of them suffer from various limitations such as high temperatures, reflux conditions, expensive reagents, harsh reaction conditions, extended reaction times, generation of waste materials, tedious work-up procedures, and low yields.…”