Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord

Kida, Yasuyuki S.; Sato, Takayuki; Miyasaka, Kota; Suto, Asami; Ogura, Toshihiko

doi:10.1073/pnas.0608946104

Cited by 65 publications

(89 citation statements)

References 31 publications

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“…In this condition, Csrp1-negative cells do not form such distinct processes (SI Table 1). As reported previously (24,25), stimulation by Wnt1 alone induces polarized elongation of cell shape even in Csrp1-negative cells (yellow arrowhead in Fig. 3B Left).…”

Section: Involution Of Thesupporting

confidence: 51%

Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin

Miyasaka

Kida

Sato

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Zebrafish Csrp1 is a member of the cysteine-and glycine-rich protein (CSRP) family and is expressed in the mesendoderm and its derivatives. Csrp1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When csrp1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.gastrulation ͉ heart ͉ Wnt ͉ zebrafish

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Section: Involution Of Thesupporting

confidence: 51%

Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin

Miyasaka

Kida

Sato

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…These observations suggest that Rho GTPases are involved in cytoskeleton stabilization during epithelial morphogenesis (Van Aelst and Symons, 2002). Moreover, Rho GTPases cooperate with Daam1 in the regulation of planar cell polarity (Zallen, 2007) and Daam1 and RhoB have also been implicated in the endocytosis of adhesion receptors and growth factors (Kida et al, 2007;Witze et al, 2008). Upregulation of both genes on Shh misexpression in the dorsal neural tube suggests that reducing matrix adhesion and increasing cell cohesion by SHH signaling also contributes to reinforcement of cell polarity.…”

Section: Discussionmentioning

confidence: 90%

Sonic Hedgehog Regulates Integrin Activity, Cadherin Contacts, and Cell Polarity to Orchestrate Neural Tube Morphogenesis

Fournier-Thibault

Blavet²,

Jarov³

et al. 2009

J. Neurosci.

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In vertebrates, the embryonic nervous system is shaped and patterned by a series of temporally and spatially regulated cell divisions, cell specifications, and cell adhesions and movements. Morphogens of the Hedgehog, Wnt, and bone morphogenetic protein families have been shown to play a crucial role in the control of cell division and specification in the trunk neural tube, but their possible implication in the regulation of adhesive events has been poorly documented. In the present study, we demonstrate that Sonic hedgehog regulates neural epithelial cell adhesion and polarity through regulation of integrin activity, cadherin cell-cell contact, and cell polarity genes in immature neural epithelial cells before the specification of neuronal cells. We propose that Sonic hedgehog orchestrates neural tube morphogenesis by coordinating adhesive and motility events with cell proliferation and differentiation.

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“…3F; see also Fig. S5 and Movie 1 in the supplementary material) (Gamse et al, 2003;Kida et al, 2007). The epithelialtype cells in the notochord continued to be observed at least until 3 dpf, when vacuolization was complete (see Fig.…”

Section: Jagged-notch Signalling Defects Cause Morphological Changes mentioning

confidence: 97%

Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions

et al. 2010

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SUMMARYIn the developing embryo, cell-cell signalling is necessary for tissue patterning and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, lossand gain-of-function analyses showed that Mib-Jag1-Notch signalling favours the development of non-vacuolated cells at the expense of vacuolated cells in the notochord. This leads to changes in the peri-notochordal basement membrane formation and patterning surrounding the muscle pioneer cells. These data reveal a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signalling-mediated cell-fate determination.

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Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord

Cited by 65 publications

References 31 publications

Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin

Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin

Sonic Hedgehog Regulates Integrin Activity, Cadherin Contacts, and Cell Polarity to Orchestrate Neural Tube Morphogenesis

Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions

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