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Abstract

Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. Microspheres have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, to simulate controlled drug release. Microspheres are characteristically free flowing solid powders, which consist of proteins or synthetic polymer, which are biodegradable in nature. Microspheres having particle size in range between 0.1-200 µm, can be delivered by several routes like oral, parentral, nasal, ophthalmic, transdermal, colonal etc. Various recent advancement in case of microspheres like mucoadhesive, hollow, floating, microballons, magnetic have been contributed to overcome the various problems that are associated with the use of microspheres, which includes site specific targeting and improved release kinetics. In future by combining various new strategies, microspheres will find a central place in novel drug delivery, particularly in diseased cell sorting, genetic materials, safe, targeting and effective drug delivery.

Alginate modification via click chemistry for biomedical applications

“…Encapsulating the drug in polymeric microspheres is an effective strategy that can control and sustain drug release. It can encapsulate the drugs in the hydrophilic alginate polymer, protect encapsulated drugs from harsh physiological microenvironments including moisture, heat, oxidation and 'mask' their horrible taste and odour (Sharma, Purwar, & Gupta, 2015), and deliver hydrophobic drugs to a specific treatment target in aqueous systems. For instance Rashidan et al encapsulated synthesized anti-cancer compounds into Na-alginate microspheres (Rashdan, Farag, El-Gendey, & Mounier, 2019).…”