D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients

Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis

“…11 Furthermore, the finding that the mice are hypertensive is consistent with human studies showing that a polymorphism E112D in PRCP is associated with hypertension and preeclampsia. 8,9 Unlike other proteins related to the plasma kallikrein/kinin system (factor XII, high molecular weight kininogen, and the bradykinin B2 receptor), deficiency of PRCP is associated with a prothrombotic state rather than thrombosis protection. 16,30,31 The finding that PRCP gt/gt are hypertensive and it is ameliorated by mitoTEMPO, an antioxidant directed to mitochrondria, suggests that endothelial cell injury may be occurring because of increased ROS.…”

“…A PRCP polymorphism (E112D) is linked to hypertension and preeclampsia. 8,9 Further, PRCP is up-regulated in the kidney in a rat hypertension model. 10 PRCP is linked to metabolic syndrome in humans.…”

“…10 PRCP is linked to metabolic syndrome in humans. 11 PRCP also degrades ␣-melanocyte stimulating hormone (␣-MSH [1][2][3][4][5][6][7][8][9][10][11][12][13] ) to its inactive ␣-MSH [1][2][3][4][5][6][7][8][9][10][11][12] form by cleaving its C-terminal Val. 12 ␣-MSH [1][2][3][4][5][6][7][8][9][10][11][12][13] stimulates an anorexigenic response.…”

The methionine synthase polymorphism c.2756A>G (D919G) influences diastolic blood pressure

“…The MTR polymorphism was reported to be associated with blood pressure response to the angiotensin-converting enzyme inhibitor benazepril in Chinese hypertensive patients. 9 To rule out the possibility that the MTR genotype exerts its effect only by altering the efficacy of antihypertensive drugs we performed a subgroup analysis showing a significant effect in untreated individuals. The association of the G-allele with lower diastolic blood pressure is in accordance with the study of Kahleova et al, 7 who found that carriers of the G-allele of the MTR c.2756A4G polymorphism had a reduced risk of juvenile hypertension.…”

Prolylcarboxypeptidase promotes angiogenesis and vascular repair

“…[11][12][13] PRCP gt/gt mice that are PRCP-deficient but not deleted, have mild hypertension with renal histologic changes. 1 In addition, PRCP converts aMSH [1][2][3][4][5][6][7][8][9][10][11][12][13] to aMSH [1][2][3][4][5][6][7][8][9][10][11][12] and PRCP gt/gt mice are lean. 4 PRCP gt/gt mice have constitutive anorexia because of decreased aMSH 1-13 metabolism with increased glucose tolerance and less insulin resistance.…”