D18S880 Microsatellite Polymorphism of Carnosinase Gene and Diabetic Nephropathy: A Meta-Analysis

Abstract

This meta-analysis confirms that the carnosinase D18S880 microsatellite polymorphism is associated with DN susceptibility, especially in the type 2 DM and the Caucasian population.

Aerobic and resistance training do not influence plasma carnosinase content or activity in type 2 diabetes

“…Adults with T2D who are homozygous for the (CTG) 5 allele of CNDP1, encoding for low plasma carnosinase activity, have reduced risk of developing diabetic nephropathy (19,26,40). In this study, the effect of exercise training or lowering hyperglycemia on plasma carnosinase content or activity was investigated.…”

“…Both human genetic association studies and animal models suggest a pivotal role for the carnosinecarnosinase system in microvascular complications of diabetes (3,19,33,34,40).…”

“…Genome-wide linkage scans and subsequent fine-mapping studies have indicated a strong association between a CTG trinucleotide repeat in CNDP1 and the susceptibility for developing diabetic nephropathy (14,19,26,40). More specifically, Caucasian type 2 diabeties (T2D) mellitus patients homozygous for the (CTG) 5 allele are less susceptible to develop diabetic nephropathy compared with T2D patients with a different genotype.…”

The (CTG)n repeat polymorphism in CNDP1 gene: New insights into an old molecule

“…Despite the inherent limitations of the case-control studies and the lack of data on levels of carnosinase-1 in South Asians, the study conducted by Yadav et al 5 supports the assumption that patients with type 2 diabetes who carry the 5L-5L genotype are less susceptible to have DN. In their meta-analysis, Zhu et al 11 also observed that such association is especially valid for the Caucasian population. In fact, no association between the (CTG) n repeat polymorphism and DN was detected in African Americans13, Mexican Americans14, American Indians15, and Japanese16 with type 2 diabetes.…”

“…Some studies have investigated the association of the (CTG) n repeat polymorphism with DN in both type 1 and type 2 diabetes, resulting in seemingly conflicting findings. This led two research groups to conduct a meta-analysis, which confirmed that this polymorphism was associated with DN susceptibility in type 2 diabetes, but not in type 1 diabetes1011. Recently, a cohort study in Caucasians with type 2 diabetes from Netherlands did not observe differential progression of renal function loss according to the (CTG) n repeat polymorphism.…”