D1 versus D2 dissection in stomach carcinoma: evaluation of postoperative mortality and complications

Vural, Veli; Saylam, Barış; Çomçalı, Bülent; Düzgün, Arife Polat; Özer, Mehmet; Çoşkun, Faruk

doi:10.5152/ucd.2013.01

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Many factors affect prolonged duration of operation. Complicated surgical procedures result in longer duration of operation and increase the risk of morbidity (19). Procedural duration is generally prolonged in advanced tumor cases, but it does not always lead to EJA leakage.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and laboratory markers used to predict leakage in esophagojejunal anastomotic leakage after total gastrectomy

et al. 2019

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Objective: Esophagojejunal anastomotic leakages, which occur in the reconstruction procedures performed after total or proximal gastrectomy, still account for one of the most significant causes of morbidity and mortality in spite of the developments seen in perioperative management and surgical techniques in gastric cancer surgery. The aim of the present study was to ascertain the risk factors for Esophagojejunal anastomotic leakages. Material and Methods: A total of 80 patients with gastric cancer, who had total gastrectomy +D2 lymph node dissection and Esophagojejunal anastomotic between January 2013 and December 2016, were retrospectively evaluated. Patients who did not have anastomotic leakages during their clinical follow-ups were allocated to Group 1, whereas those who had anastomotic leakages were allocated to Group 2. Results: A total of 58 (72.5%) out of 80 patients were males, whereas 22 (27.5%) were females. Mean age of the patients was 61.2 ± 11.2 years. There were no demographic differences between the groups. Postoperative recurrent fever (p= 0.001), C-reactive protein values on postoperative days 3 and 5 (p= 0.01), and neutrophil-to-lymphocyte ratio on postoperative day 5 (p= 0.022) were found to be statistically significant with regard to Esophagojejunal anastomotic leakages and other postoperative complications. The duration of operation (p= 0.032) and combined organ resection (p= 0.008) were ascertained as risk factors for Esophagojejunal anastomotic leakages. Conclusion: Surgeons should be careful about Esophagojejunal anastomotic leakages which are significant postoperative complications seen especially in cases where the duration of operation is prolonged, and additional organ resections are performed. Recurrent fever, high C-reactive protein levels, and neutrophil-to-lymphocyte ratio may serve as warnings for complications in postoperative follow-ups.

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Section: Discussionmentioning

confidence: 99%

Risk factors and laboratory markers used to predict leakage in esophagojejunal anastomotic leakage after total gastrectomy

et al. 2019

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“…In our study, GC patients treated with D2 lymphadenectomy also showed prolonged OS and DFS, which is consistent with the results of the above mentioned studies. However, D2 lymph node dissection might lead to higher postoperative mortality and morbidity [39]. Yarema et al claimed that D2 lymphadenectomy could improve the prognosis in European populations of GC patients, but only when the surgical quality of lymphadenectomy execution is adequate [40].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer

Hou

Luo

2016

Cell Physiol Biochem

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Aims: Recent studies have demonstrated that microRNAs (miRNAs) can serve as useful biomarkers for human cancers. The aim of this study was to evaluate the expression level of serum miRNA-206 in patients with gastric cancer (GC) and investigate its diagnostic and prognostic value. Methods: Quantitative real-time PCR was performed to evaluate serum miRNA-206 levels in 150 GC patients and 150 healthy volunteers. The association between miRNA-206 expression and clinicopathological factors as well as patient's survival was analyzed. Receiver operator curve (ROC) analysis was carried out to assess the potential value of serum miRNA-206 for GC diagnosis. Results: Serum miRNA-206 was down-regulated in GC patients compared with healthy controls (P < 0.001). Decreased serum miRNA-206 expression was significantly associated with deep local invasion, positive lymph node metastasis, and advanced clinical stage. Serum miRNA-206 expression was found to be significantly up-regulated in paired post-operative samples and reduced in patients with GC recurrence. ROC curve analysis showed that serum miRNA-206 was a useful marker for GC diagnosis, and could discriminate between recurred and non-recurred patients. Multivariate Cox regression analysis confirmed low serum miRNA-206 expression as an independent unfavorable prognostic factor for both DFS and OS of GC patients. Conclusions: These results suggest that serum miRNA-206 might not only serve as a novel diagnostic biomarker for GC, but also predict cancer recurrence and patient's prognosis.

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“…In Western society, including Turkey, gastric cancer is diagnosed in more advanced stages. Diagnosis in early stages is one of the most important factors affecting the treatment and survival of the disease [9].…”

Section: Introductionmentioning

confidence: 99%

Significance of Gastric Wall Thickening Detected in Abdominal CT Scan to Predict Gastric Malignancy

Akbaş

Bakir

Dasiran

et al. 2019

Journal of Oncology

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Background Early diagnosis of gastric cancer is one of the most important parameters affecting the survival of the disease. In this study, we aimed to stress the importance of antrum wall thickness in CT examination. Method The study included 111 patients between ages of 18 and 95 who had antral wall thickening in computed tomography and also had endoscopic evaluation performed in the same clinic. The patients were divided into two groups as benign and malignant according to the pathology results. The thickness of the antrum wall in computed tomography, hemoglobin and albumin levels, and age was compared among these two groups. Parameters with significant differences were further analyzed by multivariate analysis using logistic regression analysis. Results Of the 111 patients included in the study, 57 were male and 54 were female. Mean age was 65 years. Fifty-one patients were classified as benign and 60 patients as malignant. Mean age of the malignant patients was 70, while that of benign patients was 59 (p < 0.05). Antrum wall thickness was 13.68 ± 3.27 mm in malignant patients and 9.22 ± 2.17 mm in benign patients (p < 0.05). Similarly, hemoglobin level was significantly different in malignant and benign patients (10.78 ± 1.57 g/dl and 12.64 ± 1.43 g/dl, respectively; p < 0.05). Albumin levels were 3.36 ± 0.57 mg/dl in malignant patients and 3.97 ± 0.57 mg/dl in benign patients (p < 0.05). Conclusion Evaluation of antrum wall thickness, age, hemoglobin, and albumin values together may contribute to distinguishing the benign and malignant pathologies involving this region in patients with suspected stomach wall thickening in abdominal CT scan.

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D1 versus D2 dissection in stomach carcinoma: evaluation of postoperative mortality and complications

Abstract: The D2 procedure was associated with significantly higher postoperative mortality, morbidity, and postoperative length of hospital stay.

Cited by 9 publications

References 18 publications

Risk factors and laboratory markers used to predict leakage in esophagojejunal anastomotic leakage after total gastrectomy

Risk factors and laboratory markers used to predict leakage in esophagojejunal anastomotic leakage after total gastrectomy

Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer

Significance of Gastric Wall Thickening Detected in Abdominal CT Scan to Predict Gastric Malignancy

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