D1-receptor drugs and cocaine-seeking behavior: investigation of receptor mediation and behavioral disruption in rats

Alleweireldt, Andrea T.; Kirschner, Kenneth F.; Blake, Camille B.; Neisewander, Janet L.

doi:10.1007/s00213-002-1305-x

Cited by 36 publications

(26 citation statements)

References 37 publications

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“…In contrast to D 1 agonists that produce only minor reinstating effects when given alone, and inhibit cocaineand cue-induced relapse to cocaine-seeking behavior, systemic administration of D 2 agonists strongly induce relapse to cocaine seeking (Wise et al, 1990;Self et al, 1996;De Vries et al, 1999;Alleweireldt et al, 2002Alleweireldt et al, , 2003Dias et al, 2004). We found that high intake animals were more sensitive to the ability of D 2 receptor stimulation with quinpirole to trigger cocaine-seeking responses at the drug-paired lever.…”

Section: Brain Cocaine Levelsmentioning

confidence: 61%

“…Furthermore, it is unlikely that inhibition of cocaine seeking by the D 1 agonist is related to interfering stereotypies, since it blocked cocaine seeking at a dose that failed to affect horizontal locomotor responses to cocaine. In addition, a previous study showed that an identical combined dose of cocaine and SKF 81297 attenuated cocaine seeking without altering stereotypic behaviors that normally occur during cocaineinduced reinstatement (Alleweireldt et al, 2003).…”

Section: Discussionmentioning

confidence: 96%

“…Selective stimulation of D 2 receptors strongly induces, or reinstates, cocaine-seeking behavior after cocaine-seeking responses have been extinguished in withdrawal, whereas selective D 1 receptor stimulation produces relatively weak reinstating effects and attenuates cocaine seeking elicited by cocaine-related environmental cues when agonists are administered systemically (Wise et al, 1990;Self et al, 1996;De Vries et al, 1999;Alleweireldt et al, 2002;Dias et al, 2004). In addition, pretreatment with D 1 and D 2 agonists produces opposite effects on cocaine's ability to reinstate this behavior, since D 1 agonists attenuate and D 2 agonists facilitate cocaine seeking induced by cocaine priming injections (Self et al, 1996;Alleweireldt et al, 2003). A similar D 1 /D 2 dichotomy regulates cocaine seeking in non-human primates (Khroyan et al, 2000), and also may suppress and stimulate craving responses in humans, respectively (Haney et al, 1998(Haney et al, , 1999.…”

Section: Introductionmentioning

confidence: 99%

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Addiction-Related Alterations in D1 and D2 Dopamine Receptor Behavioral Responses Following Chronic Cocaine Self-Administration

Edwards

Whisler

Fuller

et al. 2006

Neuropsychopharmacol

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The cocaine-addicted phenotype can be modeled in rats based on individual differences in preferred levels of cocaine intake and a propensity for relapse in withdrawal. These cocaine-taking and -seeking behaviors are strongly but differentially regulated by postsynaptic D 1 and D 2 receptors in the mesolimbic dopamine system. Thus, we determined whether addiction-related differences in cocaine selfadministration would be related to differential sensitivity in functional D 1 and D 2 receptor responses. Using a population of 40 outbred Sprague-Dawley rats trained to self-administer cocaine for 3 weeks, we found that animals with higher preferred levels of cocaine intake exhibited a vertical and rightward shift in the self-administration dose-response function, and were more resistant to extinction from cocaine self-administration, similar to phenotypic changes reported in other models of cocaine addiction. After 3 weeks of withdrawal from cocaine self-administration, high intake rats were subsensitive to the ability of the D 1 agonist SKF 81297 to inhibit cocaine-seeking behavior elicited by cocaine priming, but supersensitive to cocaine seeking triggered by the D 2 agonist quinpirole, when compared to low intake rats. Additionally, high intake rats developed profound increases in locomotor responses to D 2 receptor challenge from early to late withdrawal times, whereas low intake rats developed increased responsiveness to D 1 receptor challenge. In a second experiment, responses to the mixed D 1 /D 2 agonist apomorphine and the NMDA glutamate receptor antagonist MK-801 failed to differ between low and high intake rats. These findings suggest that cocaine addiction is related specifically to differential alterations in functional D 1 and D 2 receptors and their ability to modulate cocaine-seeking behavior.

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Section: Brain Cocaine Levelsmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Addiction-Related Alterations in D1 and D2 Dopamine Receptor Behavioral Responses Following Chronic Cocaine Self-Administration

Edwards

Whisler

Fuller

et al. 2006

Neuropsychopharmacol

View full text Add to dashboard Cite

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“…Previous research has demonstrated that pretreatment with dopamine D1 receptor antagonist and agonist drugs attenuates motivation elicited by either cocaine priming or cocaine cues (Self et al, 1996(Self et al, , 2000Weissenborn et al, 1996;Khroyan et al, 2000;Ciccocioppo et al, 2001;Weiss et al, 2001;Alleweireldt et al, 2002Alleweireldt et al, , 2003. The effects of D1 agonists and antagonists on cocaine-primed reinstatement are reversed when the drugs are co-administered (Alleweireldt et al, 2003;Khroyan et al, 2003), suggesting D1 receptor mediation.…”

Section: Introductionmentioning

confidence: 99%

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Alleweireldt

Hobbs

Taylor

et al. 2005

Neuropsychopharmacol

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Amygdala D1 receptors have been implicated in the motivating effects of cocaine-conditioned cues and cocaine itself, but the specific nucleus involved is unclear. Thus, we infused the D1 antagonist, SCH-23390, into the rostral basolateral amygdala (rBLA), caudal basolateral amygdala (cBLA), or central amygdala (CEA), and tested its effects on self-administration of cocaine, as well as reinstatement of extinguished cocaine-seeking behavior by cocaine-conditioned cues or cocaine itself. Two anatomical controls, the posterior regions of basal ganglia (BG) and somatosensory/insular cortices (CTX), were also examined. Cocaine self-administration was increased and cue and cocaine reinstatement were decreased by SCH-23390 infusion into every region when examined across the hour test session, with the exception that cBLA infusion did not alter cocaine reinstatement. In the first 20 min of the session, when SCH-23390 was more localized in the target sites, self-administration was increased by infusion into the CEA, cBLA, BG, and CTX, with lesser increases in the rBLA. Cocaine reinstatement was attenuated during the first 20 min only by infusion into the CEA, rBLA, and CTX. Cue reinstatement was not reliably observed in the first 20 min, but there was a trend for attenuation by infusion into the cBLA, and surprisingly, significant attenuations in the BG and CTX. The findings suggest that D1 receptors in subregions of the amygdala play differential roles in the reinforcing/motivational effects of cocaine, while the cue reinstatement effects are less clear. Further research is needed to examine the novel findings that neighboring regions of the BG and CTX may play a role in motivation for cocaine.

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“…Several studies using animal models of drug addiction have reported changes in responding elicited by cocaine and/or cocaine-related stimuli following systemic administration of dopamine receptor agonists and antagonists (Self et al 1996;Weissenborn et al 1996;Caine et al 1999;Khroyan et al 2000;Alleweireldt et al 2002;Crombag et al 2002;Alleweireldt et al 2003;Khroyan et al 2003;Olsen and Duvauchelle 2006). Interestingly, systemic injections of D 1 -like receptor agonists or antagonists produce similar, rather than opposing, dose-dependent reductions in responding maintained by cocaine during cocaine selfadministration sessions (Caine et al 2000;Platt et al 2001;Mutschler and Bergman 2002;Barett et al 2004), suggesting an important inhibitory role for D 1 receptors in mediating cocaine self-administration.…”

Section: Introductionmentioning

confidence: 99%

Role of dopamine D1 receptors in the prefrontal dorsal agranular insular cortex in mediating cocaine self-administration in rats

et al. 2008

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Rationale-Orbital/insular areas of the prefrontal cortex (PFC) are implicated in cocaine addiction. However, the role of dopamine D 1 receptors in mediating cocaine self-administration in these subregions remains unknown.Objectives-To define the role of the dorsal agranular insular (AId) sub-region of the PFC, we investigated the effects of D 1 receptor manipulation on self-administration behavior maintained by cocaine and cocaine-related stimuli. Methods-Rats

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D1-receptor drugs and cocaine-seeking behavior: investigation of receptor mediation and behavioral disruption in rats

Cited by 36 publications

References 37 publications

Addiction-Related Alterations in D1 and D2 Dopamine Receptor Behavioral Responses Following Chronic Cocaine Self-Administration

Addiction-Related Alterations in D1 and D2 Dopamine Receptor Behavioral Responses Following Chronic Cocaine Self-Administration

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Role of dopamine D1 receptors in the prefrontal dorsal agranular insular cortex in mediating cocaine self-administration in rats

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