D1/D5 dopamine receptors modulate spatial memory formation

Silva, Weber C.N. da; Köhler, Cristiano A.; Radiske, Andressa; Cammarota, Martı́n

doi:10.1016/j.nlm.2012.01.005

Cited by 75 publications

(56 citation statements)

References 33 publications

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“…They were dissolved in saline and stored at −20 • C. Before use, aliquots were diluted to working concentration with vehicle (0.9% saline). The doses used were based on previous work in which their effect was established [39,[48][49][50][51][52].…”

Section: Drugsmentioning

confidence: 99%

“…Memory consolidation is the process that makes recently acquired information stable over a period of time after families of receptors: the D1-family (D1/D5 receptors) and the D2-family (D2/D3/D4 receptors) [33][34][35]. The D1/D5 receptors have received increasing attention, because of their significant role in the regulation of both hippocampus-dependent synaptic plasticity and memory [14,[36][37][38][39]. A relatively different expression of D1 and D5 receptors could mediate this effect, perhaps in part by influencing the different phases of long-term potentiation (LTP), due to the fact that the two types of receptors engage different signal cascades.…”

Section: Introductionmentioning

confidence: 99%

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D1 and D5 dopamine receptors participate on the consolidation of two different memories

Furini

Myskiw

Schmidt

et al. 2014

Behavioural Brain Research

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Section: Drugsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

D1 and D5 dopamine receptors participate on the consolidation of two different memories

Furini

Myskiw

Schmidt

et al. 2014

Behavioural Brain Research

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“…When released into the dorsal hippocampus, dopamine binds to D1/D5 receptors to promote attention, episodic memory formation, spatial learning, and synaptic plasticity (3)(4)(5). Successful spatial learning requires that hippocampal place cells, location-encoding pyramidal neurons (6), display consistent and stable patterns of neural activity, a process that can be enhanced by selective attention to spatial cues and by dopamine agonists (7,8).…”

mentioning

confidence: 99%

Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

Kempadoo

Mosharov

Choi

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

496

507

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Dopamine neurotransmission in the dorsal hippocampus is critical for a range of functions from spatial learning and synaptic plasticity to the deficits underlying psychiatric disorders such as attentiondeficit hyperactivity disorder. The ventral tegmental area (VTA) is the presumed source of dopamine in the dorsal hippocampus. However, there is a surprising scarcity of VTA dopamine axons in the dorsal hippocampus despite the dense network of dopamine receptors. We have explored this apparent paradox using optogenetic, biochemical, and behavioral approaches and found that dopaminergic axons and subsequent dopamine release in the dorsal hippocampus originate from neurons of the locus coeruleus (LC). Photostimulation of LC axons produced an increase in dopamine release in the dorsal hippocampus as revealed by high-performance liquid chromatography. Furthermore, optogenetically induced release of dopamine from the LC into the dorsal hippocampus enhanced selective attention and spatial object recognition via the dopamine D1/D5 receptor. These results suggest that spatial learning and memory are energized by the release of dopamine in the dorsal hippocampus from noradrenergic neurons of the LC. The present findings are critical for identifying the neural circuits that enable proper attention selection and successful learning and memory.dopamine | locus coeruleus | hippocampus | memory | attention D opamine is a neurotransmitter released throughout the brain to encode salience and facilitate the formation of associative memory (1, 2). When released into the dorsal hippocampus, dopamine binds to D1/D5 receptors to promote attention, episodic memory formation, spatial learning, and synaptic plasticity (3-5). Successful spatial learning requires that hippocampal place cells, location-encoding pyramidal neurons (6), display consistent and stable patterns of neural activity, a process that can be enhanced by selective attention to spatial cues and by dopamine agonists (7,8). Conversely, dopamine receptor blockade attenuates the ability of spatial attention to stabilize the firing pattern of hippocampal place cells (8). The role of dopamine in driving attentional processes is highlighted by the fact that methylphenidate, one of the most common treatments for attention-deficit hyperactivity disorder (ADHD), improves attention by increasing synaptic availability of dopamine in the hippocampus, as well as in the prefrontal cortex and striatum (9-11). These findings suggest that dopamine is critical for the selective attention underlying spatial learning and memory.For decades, the ventral tegmental area (VTA) has been the presumed source of hippocampal dopamine. However, in recent years, the source of dopamine in the dorsal hippocampus has become less clear. McNamara et al. (12) argued that a dopaminergic projection from the VTA to the dorsal hippocampus promoted hippocampal reactivation during sleep and stabilized memory. However, only 10% of the sparse projection from the VTA to the hippocampus contains dopamine, raising the...

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“…25) Intra-CA1 administration of the D1/D5 receptor agonist SKF38393 promotes spatial memory processing in the water maze. 26) As SKF83959 is an agonist of D 1 -D 2 heteromer, the results of our study may imply a role of this heteromer in memory, which shall be very interesting. It is also interesting that SKF83959 treatment reverses the scopolamine-induced BDNF dysfunction in the hippocampus, but not cortex, and this is consistent with Jiang et al 12) For this finding, currently there are no exact explanations, perphaps D 1 -D 2 heteromer has no distributions in the cortex.…”

Section: Discussionmentioning

confidence: 62%

SKF83959 Has Protective Effects in the Scopolamine Model of Dementia

Sheng

Zhang

Gao

et al. 2018

Biological & Pharmaceutical Bulletin

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Patients with Alzheimer's disease (AD) always have cognitive impairments. In this study we investigated whether 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (SKF83959) has improvements on cognitive dysfunction. The scopolamine model of dementia was used to investigate the anti-amnesic activities of SKF83959, and then, Western blotting and pharmacological inhibitor were used to assay the anti-amnesic mechanisms of SKF83959. It was found that SKF83959 administration significantly improved the scopolamine-induced memory impairments in the passive avoidance task, Y-maze test, and Morris water maze task. Moreover, SKF83959 treatment significantly antagonized the down-regulating effects of scopolamine on brain-derived neurotrophic factor (BDNF) signaling cascade in the hippocampus, but not cortex. Importantly, the usage of K252a, a selective inhibitor of tyrosine kinase B (TrkB), significantly attenuated the protective effects of SKF83959 in the scopolamine model. Collectively, this study shows that SKF83959 has beneficial effects in the scopolamine model of dementia by modulation of hippocampal BDNF signaling, implying a novel and potential therapeutic agent for treating dementia in AD.Key words brain-derived neurotrophic factor; memory; scopolamine; SKF83959 As a world-wide neurodegenerative disease, Alzheimer's disease (AD) causes huge damage to our society.1) In clinical, patients with AD always have dementia, meaning the loss of memory.2,3) Dementia is very common in older persons, and leads to severe interference in occupational and social performance. Current researches have revealed that patients with AD have severe cholinergic dysfunction in the brain, [4][5][6] and some cholinergic antagonists, especially scopolamine, have been shown to induce memory impariments in rodents. 7) In contrast, some acetylcholinesterase inhibitors (AChEIs), such as donepezil, were developed for AD therapy in clinical. However, current AChEIs used clinically have various adverse effects including diarrhea, insomnia and vomiting, and their efficacy are not very good.8) Therefore, developing novel therapeutic agents to treat dementia in AD is very necessary.6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (SKF83959) is one compound which belongs to benzazepine family and has been acknowledged as a selective D 1 -D 2 heteromer agonist. Until now, a lot of reports have been showing the effects of SKF83959 on the brain. For example, Wu et al. showed that SKF83959 has protective effects against neuroinflammation. 9)Chu et al. reported that SKF83959 has promoting effects on neuronal release of glutamate. 10) Zhang et al. found that SKF83959 administration has beneficial and reversing effects in the 6-hydroxy-dopamine (6-OHDA) model of Parkinson's disease. 11) We noticed that in 2014, Jiang et al. demonstrated the antidepressant effects of SKF83959 in mice which were mediated through activating the brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (Tr...

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D1/D5 dopamine receptors modulate spatial memory formation

Cited by 75 publications

References 33 publications

D1 and D5 dopamine receptors participate on the consolidation of two different memories

D1 and D5 dopamine receptors participate on the consolidation of two different memories

Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

SKF83959 Has Protective Effects in the Scopolamine Model of Dementia

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