D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions

Azzara, Anthony V.; Bodnar, Richard J.; Delamater, Andrew R.; Sclafani, Anthony

doi:10.1016/s0091-3057(01)00484-1

Cited by 68 publications

(96 citation statements)

References 19 publications

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“…The differential effects of SCH23390 (inhibitory) and raclopride (no effect) on the STFP are in agreement with D1 and D2 receptors having opposing roles in appetitive conditioning (Eyny and Horvitz, 2003) and in line with results showing a role for the D1 (Beninger and Miller, 1998;Smith-Roe and Kelley, 2000;Azzara et al, 2001;Baldwin et al, 2002;Eyny and Horvitz, 2003;Touzani et al, 2008) but not D2 (Bushnell and Levin, 1993) receptor in appetitive learning in non-social learning paradigms. D2-type receptors can act in direct antagonism to the D1-type receptors in learning mechanisms, with D1 activating and D2 inhibiting the regulatory DA and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32; Calabresi et al, 2000;Otani et al, 2003;Calabresi et al, 2007;Nishi et al, 1997;Svenningsson et al, 2004) in glutamate-dependent long-term potentiation of synapses (Nishi et al, 1997;Otani et al, 2003;Svenningsson et al, 2004;Lemon and Manahan-Vaughan, 2006).…”

Section: Effects Of the Dopaminergic D1-type And D2-type Antagonists supporting

confidence: 86%

“…This may be due to an interaction between the involvement of DA in spontaneous and acquired food preference. Furthermore, SCH23390, but not raclopride, blocked the acquisition of flavor preferences in a flavor-nutrientconditioning paradigm (Azzara et al, 2001). This result is more similar to ours, suggesting that the post-ingestive consequences of eating may contribute to the expression of the STFP.…”

Section: Effects Of the Dopaminergic D1-type And D2-type Antagonists mentioning

confidence: 99%

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Differential Effects of Dopamine Receptor D1-Type and D2-Type Antagonists and Phase of the Estrous Cycle on Social Learning of Food Preferences, Feeding, and Social Interactions in Mice

Choleris

Clipperton-Allen

Gray

et al. 2011

Neuropsychopharmacol

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The neurobiological bases of social learning, by which an animal can 'exploit the expertise of others' and avoid the disadvantages of individual learning, are only partially understood. We examined the involvement of the dopaminergic system in social learning by administering a dopamine D1-type receptor antagonist, SCH23390 (0.01, 0.05, and 0.1 mg/kg), or a D2-type receptor antagonist, raclopride (0.1, 0.3, and 0.6 mg/kg), to adult female mice prior to socially learning a food preference. We found that while SCH23390 dose-dependently inhibited social learning without affecting feeding behavior or the ability of mice to discriminate between differently flavored diets, raclopride had the opposite effects, inhibiting feeding but leaving social learning unaffected. We showed that food odor, alone or in a social context, was insufficient to induce a food preference, proving the specifically social nature of this paradigm. The estrous cycle also affected social learning, with mice in proestrus expressing the socially acquired food preference longer than estrous and diestrous mice. This suggests gonadal hormone involvement, which is consistent with known estrogenic regulation of female social behavior and estrogen receptor involvement in social learning. Furthermore, a detailed ethological analysis of the social interactions during which social learning occurs showed raclopride-and estrous phase-induced changes in agonistic behavior, which were not directly related to effects on social learning. Overall, these results suggest a differential involvement of the D1-type and D2-type receptors in the regulation of social learning, feeding, and agonistic behaviors that are likely mediated by different underlying states.

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Section: Effects Of the Dopaminergic D1-type And D2-type Antagonists supporting

confidence: 86%

Section: Effects Of the Dopaminergic D1-type And D2-type Antagonists mentioning

confidence: 99%

Differential Effects of Dopamine Receptor D1-Type and D2-Type Antagonists and Phase of the Estrous Cycle on Social Learning of Food Preferences, Feeding, and Social Interactions in Mice

Choleris

Clipperton-Allen

Gray

et al. 2011

Neuropsychopharmacol

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“…First, these agents may have interfered with associative processes (e.g., memory retrieval) that normally activate motivational systems, rather than disrupting these systems per se. Although this possibility cannot be ruled out on the basis of the present data, the literature suggests that D1 and D2 antagonists do not reliably interfere with the expression of learned responses, including conditioned fear (Inoue et al, 1996;Greba and Kokkinidis, 2000), conditioned taste preference (Azzara et al, 2001), and ethanol-induced conditioned place preference (Cunningham et al, 1992). Also, microinjections of a D2 antagonist (raclopride) into the basolateral amygdala, a critical substrate for associative learning and memory, do not interfere with conditioned cocaine-seeking behavior (See at al., 2001).…”

Section: Discussioncontrasting

confidence: 53%

Reversal of Ethanol-Seeking Behavior by D1 and D2 Antagonists in an Animal Model of Relapse: Differences in Antagonist Potency in Previously Ethanol-Dependent versus Nondependent Rats

Liu

Weiss²

2002

J Pharmacol Exp Ther

115

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Mesocorticolimbic dopamine (DA) transmission has been implicated in the consummatory and, more recently, the incentive-motivational aspect of ethanol's actions. The purpose of this study was to test whether ethanol-seeking behavior induced by an ethanol-associated contextual stimulus is sensitive to antagonism of DA transmission. Male Wistar rats were trained to orally self-administer 10% ethanol and to associate olfactory discriminative stimuli with the availability of ethanol (S ϩ ) versus nonreward (S Ϫ ). Ethanol-reinforced operant responding then was extinguished by withholding ethanol and the associated S ϩ . After reaching a predetermined extinction criterion, reinstatement tests were conducted in which the animals were presented noncontingently with only the S ϩ or S Ϫ . Exposure to the S ϩ but not the S Ϫ reinstated responding at the previously active lever. The D1 antagonist R(ϩ)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H -3-benzazepine hydrochloride (SCH23390; 5, 10, 50 g/kg s.c.) and the D2 antagonist eticlopride (5, 10, 50 g/kg s.c.) dose dependently decreased the number of S ϩ -induced responses and increased response latency. During a second test, conducted in the same rats, 3 weeks after withdrawal from a 12-day ethanol vapor inhalation procedure, the response-reinstating efficacy of the S ϩ remained unaltered. However, the potency of both DA antagonists to inhibit the S ϩ -induced drug-seeking response was significantly increased. The results confirm that ethanol-related contextual stimuli reliably elicit drug-seeking behavior and suggest that this effect requires activation of DA neurotransmission. The results also indicate that chronic ethanol exposure produces changes in D1 and D2 receptor function that lead to enhanced sensitivity to the behavioral effects of antagonists for these receptors.

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“…Foods that are high in sugar and fat are known to activate the reward system and promote eating and prompt conditioning (41). Dopamine antagonists will attenuate this response and supress intake of sweets in rats (40,(42)(43)(44).…”

Section: Dopaminementioning

confidence: 99%

Effects of sugar solutions on hypothalamic appetite regulation

Colley¹,

Castonguay²

2015

Physiology & Behavior

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There are multiple hypotheses for the causes of the obesity epidemic. One such hypothesis is that dietary intake patterns have significantly shifted to include unprecedented amounts of refined sugar. We set out to determine some the unique metabolic changes that occur with initial exposure to dilute glucose, sucrose, high fructose corn syrup, or fructose solutions. Rats were given access to food, water and a sugar solution for 24 h, after which blood and tissues were collected. Fructose access (as opposed to other sugars investigated) resulted in a doubling of circulating triglycerides. Glucose consumption resulted in upregulation of 7 satiety related hypothalamic peptides whereas changes in gene expression were mixed for remaining sugars. Also, following multiple verification assays, 6 satiety related peptides were verified as being affected by sugar intake. These data provide evidence that not all sugars are equally effective in affecting the control of intake.

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D1 but not D2 dopamine receptor antagonism blocks the acquisition of a flavor preference conditioned by intragastric carbohydrate infusions

Cited by 68 publications

References 19 publications

Differential Effects of Dopamine Receptor D1-Type and D2-Type Antagonists and Phase of the Estrous Cycle on Social Learning of Food Preferences, Feeding, and Social Interactions in Mice

Differential Effects of Dopamine Receptor D1-Type and D2-Type Antagonists and Phase of the Estrous Cycle on Social Learning of Food Preferences, Feeding, and Social Interactions in Mice

Reversal of Ethanol-Seeking Behavior by D1 and D2 Antagonists in an Animal Model of Relapse: Differences in Antagonist Potency in Previously Ethanol-Dependent versus Nondependent Rats

Effects of sugar solutions on hypothalamic appetite regulation

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