D-α-tocopherol polyethylene glycol 1000 succinate-based microemulsion delivery system: Stability enhancement of physicochemical properties of luteolin

β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin

“… Luo and Chen, 2019 3 D-α-tocopherol polyethylene glycol 1000 succinate Microemulsion The antioxidant activity of luteolin was enhanced. Zheng et al, 2023 4 Zein-Caseinate Nanoparticle The bioavailability of luteolin was enhanced by 2.92 times. Shape memory films method (under reduced pressure to remove the tetrahydrofuran) Xu et al, 2023 5 Whey protein isolate Liposome The thermal stability and antioxidant activity of luteolin were improved.…”

Nano-scale drug delivery systems for luteolin: advancements and applications

“…This system achieved an in vitro drug release ratio exceeding 80% within 24 hours, offering a potential route for the oral administration of Lu. 28 Moreover, achieving targeted delivery of Lu is possible through strategically altering the physicochemical properties of the nanocarriers or incorporating specific ligands. For example, in glioma therapy, folic acid-modified nanometer-scale micelles composed of poly(ethylene glycol)-poly(ε-caprolactone) can be employed for targeted delivery of Lu.…”