“… Luo and Chen, 2019 3 D-α-tocopherol polyethylene glycol 1000 succinate Microemulsion The antioxidant activity of luteolin was enhanced. Zheng et al, 2023 4 Zein-Caseinate Nanoparticle The bioavailability of luteolin was enhanced by 2.92 times. Shape memory films method (under reduced pressure to remove the tetrahydrofuran) Xu et al, 2023 5 Whey protein isolate Liposome The thermal stability and antioxidant activity of luteolin were improved.…”
“… Luo and Chen, 2019 3 D-α-tocopherol polyethylene glycol 1000 succinate Microemulsion The antioxidant activity of luteolin was enhanced. Zheng et al, 2023 4 Zein-Caseinate Nanoparticle The bioavailability of luteolin was enhanced by 2.92 times. Shape memory films method (under reduced pressure to remove the tetrahydrofuran) Xu et al, 2023 5 Whey protein isolate Liposome The thermal stability and antioxidant activity of luteolin were improved.…”
“…This system achieved an in vitro drug release ratio exceeding 80% within 24 hours, offering a potential route for the oral administration of Lu. 28 Moreover, achieving targeted delivery of Lu is possible through strategically altering the physicochemical properties of the nanocarriers or incorporating specific ligands. For example, in glioma therapy, folic acid-modified nanometer-scale micelles composed of poly(ethylene glycol)-poly(ε-caprolactone) can be employed for targeted delivery of Lu.…”
Nano-scale drug delivery systems including micelles, nanocarrier-based systems, emulsified drug delivery systems, and vesicular drug delivery systems were designed for luteolin.
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