D-Tagatose Is a Promising Sweetener to Control Glycaemia: A New Functional Food

Abstract

The objective of the current research was to review and update evidence on the dietary effect of the consumption of tagatose in type 2 diabetes, as well as to elucidate the current approach that exists on its production and biotechnological utility in functional food for diabetics. Articles published before July 1, 2017, were included in the databases PubMed, EBSCO, Google Scholar, and Scielo, including the terms “Tagatose”, “Sweeteners”, “Diabetes Mellitus type 2”, “Sweeteners”, “D-Tag”. D-Tagatose (D-tag) is an isomer of fructose which is approximately 90% sweeter than sucrose. Preliminary studies in animals and preclinical studies showed that D-tag decreased glucose levels, which generated great interest in the scientific community. Recent studies indicate that tagatose has low glycemic index, a potent hypoglycemic effect, and eventually could be associated with important benefits for the treatment of obesity. The authors concluded that D-tag is promising as a sweetener without major adverse effects observed in these clinical studies.

The unaided recovery of marathon-induced serum metabolome alterations

“…Furthermore, since the majority of the erythritol is absorbed rather than metabolized 26 , as well as the fact that it is a well-known alternative sugar added to low-calorie foods 27 frequently ingested by athletes, the alterations of this metabolite 24 h and 48 h post-marathon may also be due to reduced ingestion of such foods by the athletes during the recovery period. Similarly, several of the metabolites in Table 1, including mannitol, psicose, sorbose 27,28 , tagatose 29 , and xylose 24 , are natural constituents of fruit and vegetables, Food and Drug Administration approved alternative bulk sweeteners, and/or the products of metabolised sweeteners such as threonic acid 30 , and arabitol via arabinose 31 . Considering that endurance races reportedly alter gut microbiome composition, as well as increase intestinal permeability resulting in gut microbiome (GM) metabolite migration 32 , reductions in several Lipid metabolism.…”

Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study

“…This is because certain simple sugars, such as fructose, with a relatively low GI (=23) [36], could induce insulin-independent additional metabolic effects [50] on uric acid levels, blood pressure, liver cell triacylglycerides content and hepatic insulin sensitivity when consumed in high amounts [51]. On the other hand, tagatose is a low GI (=3) monosaccharide [36], that promoting a GLP-1 release in a similar extent to fructose without any significant GIP secretion response [52] and exhibiting an interesting glucose-lowering effect [53]. In this study, we assessed two of the most employed slow-digesting carbohydrates in ONS-D: isomaltulose and sucromalt.…”

Food Industrial Production of Monosaccharides Using Microbial, Enzymatic, and Chemical Methods

“…d-Tagatose is a C-3 epimer of d-galactose ( Figure 2). d-Tagatose is contained in many dairy products [64]. With regard to health benefits, this sugar has low caloric value [65], has inhibitory effects against metabolic syndrome, and is beneficial to teeth by suppressing the growth of S. mutans [66].…”