D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

Abstract

Fused filament fabrication (FFF) is a process used to manufacture oral forms adapted to the needs of patients. Polyethylene oxide (PEO) filaments were produced by hot melt extrusion (HME) to obtain a filament suitable for the production of amiodarone hydrochloride oral forms by FFF 3D printing. In order to produce personalized oral forms adapted to the patient characteristics, filaments used by FFF must be controlled in terms of mass homogeneity along filament. This work highlights the relation between filament mass homogeneity and its diameter. This is why the impact of filler excipients physical properties was studied. It has been showed that the particle’s size distribution of the filler can modify the filament diameter variability which has had an impact on the mass of oral forms produced by FFF. Through this work it was shown that D-Sorbitol from Carlo Erba allows to obtain a diameter variability of less than 2% due to its unique particle’s size distribution. Using the filament produced by HME and an innovating calibration method based on the filament length, it has been possible to carry out three dosages of 125 mg, 750 mg and 1000 mg by 3D printing with acceptable mass uniformity.

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

“…The 5-ASA did not show signs of thermal decomposition until reaching approximately 230 °C (T max 292 °C). These data are also in accordance with previous reports [ 15 , 39 , 52 ].…”

“…The sorbitol remained thermally stable until it was heated to ~250 • C, with its maximum degradation at 357 • C. The 5-ASA did not show signs of thermal decomposition until reaching approximately 230 • C (T max 292 • C). These data are also in accordance with previous reports [15,39,52].…”

“…Only a weak and very broad endotherm (below 100 °C) could be found in the DSC curve of Aerosil ® due to the evaporation of adsorbed water. The thermal events of the raw materials agree with the data provided by the manufacturer [33] and the values reported in the literature [15,36,38,39,51,52]. The thermogram of the physical mixture resembled that of PVA (the main component), with the melting peaks of sorbitol and 5-ASA clearly distinguished, confirming that their solid-state structures were not modified by physical mixing.…”

Irreversible colorimetric bio-based curcumin bilayer membranes for smart food packaging temperature control applications

“…It has been reported that the decomposition of d -sorbitol starts at 200 °C. 40 The DSC data of the membrane containing triethanolamine, cellulose acetate, sorbitol, and acetone are shown in Fig. S2,† where 3 endothermic peaks at 127, 206, and 274 °C and 1 exothermic peak at 337 °C can be seen, which could be related to the boiling of triethanolamine, a phenomenon that occurs at 335 °C.…”

3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors

“…Currently, additive manufacturing (AM), or 3D printing, is widely applied in many areas of science and technology, such as medicine [ 39 , 40 , 41 , 42 , 43 , 44 ], engineering [ 45 , 46 , 47 , 48 ], and material sciences [ 49 , 50 , 51 , 52 , 53 ]. In chemistry, 3D printing improves process efficiency by manufacturing fluidics [ 54 , 55 , 56 ], customized reactors for organic synthesis [ 57 , 58 , 59 , 60 , 61 ], and specific catalytic devices [ 62 , 63 , 64 ].…”