d-serine prevents cognitive deficits induced by acute stress

Guercio, Gerson D.; Bevictori, L.E.; Vargas-Lopes, Charles; Madeira, Caroline; Oliveira, Ana F.; Carvalho, Vinícius Frias; d'Avila, Joana C; Panizzutti, Rogério

doi:10.1016/j.neuropharm.2014.06.021

Cited by 33 publications

(24 citation statements)

References 54 publications

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“…Performance of day 1 in yellow, day 2 in orange, day 3 in red, day 4 in black. The percentage of use of directed strategies is plotted in black and percentage of failures to reach platform is plotted in gray [Color figure can be viewed at wileyonlinelibrary.com] supplemented with either saline or D-serine intraperitoneally (an approach described to increase the intracerebral levels of D-serine (Guercio et al, 2014;Han et al, 2015;Takata et al, 2011)).…”

Section: D-serine Administration Rescues the Hippocampal-prefrontalmentioning

confidence: 99%

Astrocytic signaling supports hippocampal–prefrontal theta synchronization and cognitive function

Sardinha

Guerra‐Gomes

Caetano

et al. 2017

Glia

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Astrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex. Moreover, we found a strong cognitive impairment in tasks depending on this network. Importantly, the supplementation with d-serine completely restores hippocampal-prefrontal theta synchronization and rescues the spatial memory and long-term memory of dnSNARE mice. We provide here novel evidence of long distance network modulation by astrocytes, with direct implications to cognitive function.

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Section: D-serine Administration Rescues the Hippocampal-prefrontalmentioning

confidence: 99%

Astrocytic signaling supports hippocampal–prefrontal theta synchronization and cognitive function

Sardinha

Guerra‐Gomes

Caetano

et al. 2017

Glia

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“…22 Consistent with a possible role in pathological states, in vitro studies have shown increased release of d -serine from both glial and neuronal cells and NMDAR activation under injury, in particular in AD model systems. 23, 24 On the other hand, exogenous d -serine administration may improve behavioral deficits in experimental models 25, 26 and may act as a NMDAR antagonist under some circumstances. 27 …”

Section: Introductionmentioning

confidence: 99%

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

et al. 2015

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Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been associated with neurological disorders, including schizophrenia and epilepsy. However, whether d-serine levels are deregulated in AD remains elusive. Here, we first measured D-serine levels in post-mortem hippocampal and cortical samples from nondemented subjects (n=8) and AD patients (n=14). We next determined d-serine levels in experimental models of AD, including wild-type rats and mice that received intracerebroventricular injections of amyloid-β oligomers, and APP/PS1 transgenic mice. Finally, we assessed d-serine levels in the cerebrospinal fluid (CSF) of 21 patients with a diagnosis of probable AD, as compared with patients with normal pressure hydrocephalus (n=9), major depression (n=9) and healthy controls (n=10), and results were contrasted with CSF amyloid-β/tau AD biomarkers. d-serine levels were higher in the hippocampus and parietal cortex of AD patients than in control subjects. Levels of both d-serine and serine racemase, the enzyme responsible for d-serine production, were elevated in experimental models of AD. Significantly, d-serine levels were higher in the CSF of probable AD patients than in non-cognitively impaired subject groups. Combining d-serine levels to the amyloid/tau index remarkably increased the sensitivity and specificity of diagnosis of probable AD in our cohort. Our results show that increased brain and CSF d-serine levels are associated with AD. CSF d-serine levels discriminated between nondemented and AD patients in our cohort and might constitute a novel candidate biomarker for early AD diagnosis.

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“…Previous studies have shown that distinct acute or chronic stress paradigms can decrease PPI responses. This effect of stress on PPI has been described in social isolated mice [8] and Wistar [9] or female LongEvans hooded rats [10], after acute restraint stress in C57BL/6 mice [11] or repeated restraint stress in Brown Norway rats [12], and http://dx.doi.org/10.1016/j.bbr.2015.04.023 0166-4328/© 2015 Elsevier B.V. All rights reserved. after rapid eye movement sleep deprivation [13] or predator exposure [14] in male Sprague-Dawley rats.…”

Section: Introductionmentioning

confidence: 79%

Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress

Pallarès

Llidó

Mòdol

et al. 2015

Behavioural Brain Research

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d-serine prevents cognitive deficits induced by acute stress

Cited by 33 publications

References 54 publications

Astrocytic signaling supports hippocampal–prefrontal theta synchronization and cognitive function

Astrocytic signaling supports hippocampal–prefrontal theta synchronization and cognitive function

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress

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