D-serine and nmda receptor 1 expression in patients with intractable epilepsy

Zhang, Xinyue; Hu, Boqi; Lu, Linwei; Xu, Dahai; Sun, Lichao; Lin, Weihong

doi:10.5137/1019-5149.jtn.28138-19.2

Cited by 3 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Serines and Epilepsymentioning

confidence: 99%

“…A subsequent study in 2021 performed immunofluorescence staining and western blotting to identify the expression patters of D-serine and NMDA receptor 1 in patients with intractable epilepsy [ 58 ]. The level of D-serine was greater in the neurons and glial cells in patients afflicted with intractable epilepsy than in control participants [ 58 ]. The mean absorbance of NMDA receptor 1 was also higher in patients with intractable epilepsy when compared with control participants, indicating the possible implication of this pathway in the Epileptogenesis [ 58 ].…”

Section: Serines and Epilepsymentioning

confidence: 99%

See 1 more Smart Citation

L-serine: Neurological Implications and Therapeutic Potential

Phone Myint,

Sun

2023

Biomedicines

View full text Add to dashboard Cite

L-serine is a non-essential amino acid that plays a vital role in protein synthesis, cell proliferation, development, and sphingolipid formation in the central nervous system. It exerts its effects through the activation of glycine receptors and upregulation of PPAR-γ, resulting in neurotransmitter synthesis, neuroprotection, and anti-inflammatory effects. L-serine shows potential as a protective agent in various neurological diseases and neurodegenerative disorders. Deficiency of L-serine and its downstream products has been linked to severe neurological deficits. Despite its crucial role, there is limited understanding of its mechanistic production and impact on glial and neuronal cells. Most of the focus has been on D-serine, the downstream product of L-serine, which has been implicated in a wide range of neurological diseases. However, L-serine is approved by FDA for supplemental use, while D-serine is not. Hence, it is imperative that we investigate the wider effects of L-serine, particularly in relation to the pathogenesis of several neurological deficits that, in turn, lead to diseases. This review aims to explore current knowledge surrounding L-serine and its potential as a treatment for various neurological diseases and neurodegenerative disorders.

show abstract

Section: Serines and Epilepsymentioning

confidence: 99%

Section: Serines and Epilepsymentioning

confidence: 99%

L-serine: Neurological Implications and Therapeutic Potential

Phone Myint,

Sun

2023

Biomedicines

View full text Add to dashboard Cite

show abstract

“…D-serine and NMDAR were found to be significantly upregulated in patients with intractable epilepsy (Zhang et al, 2021). Therefore, the D-serine signal pathway may be a potential target for epilepsy therapy.…”

Section: D-serinementioning

confidence: 99%

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Chen

Liu

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflammation, thereby they may participate in epileptogenesis. NMDARs belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian CNS. Despite numerous studies focusing on the role of NMDAR in epilepsy, the relationship appeared to be elusive. In this article, we reviewed the regulation of NMDAR and possible mechanisms of NMDAR in epilepsy and in respect of onset, development, and treatment, trying to provide more evidence for future studies.

show abstract

“…The modulation of the GMS of the NMDAR is low, given the low saturation in vivo despite the high CSF concentrations of glycine [ 31 ]. D-serine serves as a major endogenous co-agonist of the NMDAR, and D-serine levels were recently found to be upregulated in intractable epilepsy [ 32 , 33 , 34 ]. It is possible that endogenous glycine does not fully stimulate NMDARs as suggested by the selective potentiation of the convulsant activity of NMDA by D-serine [ 35 ].…”

Section: Nmdar Complexmentioning

confidence: 99%

“…In human patients with symptomatic epilepsies, the regulation of the GluN2B subunit of the NMDAR complex via NRG1-ErbB4-Src signaling pathways was identified as a potential modulating target through the use of the immunoblotting technique [ 69 ]. In patients with intractable temporal lobe epilepsies, D-serine and NMDAR1 expressions were significantly increased [ 34 ]. These observations highlight the importance of neurochemical targeting, which can be further explored in the future to guide anti-NMDAR complex therapies.…”

Section: Nmdar Alterations and Their Role In Human Epilepsymentioning

confidence: 99%

Targeting NMDA Receptor Complex in Management of Epilepsy

2022

View full text Add to dashboard Cite

N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and preclinical studies have revealed that the abnormal expression or function of these receptors can underlie the pathophysiology of seizure disorders and epilepsy. Accordingly, NMDAR modulators have been shown to exert anticonvulsive effects in various preclinical models of seizures, as well as in patients with epilepsy. In this review, we provide an update on the pathologic role of NMDARs in epilepsy and an overview of the NMDAR antagonists that have been evaluated as anticonvulsive agents in clinical studies, as well as in preclinical seizure models.

show abstract

D-serine and nmda receptor 1 expression in patients with intractable epilepsy

Cited by 3 publications

References 25 publications

L-serine: Neurological Implications and Therapeutic Potential

L-serine: Neurological Implications and Therapeutic Potential

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Targeting NMDA Receptor Complex in Management of Epilepsy

Contact Info

Product

Resources

About