D(−)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models

Yang, Li; Wu, Qi; Deng, Yong; Lv, Hongming; Qiu, Jiazhang; Chi, Gefu; Feng, Hailan

doi:10.1016/j.intimp.2015.04.016

Cited by 36 publications

(25 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with this finding, the intraperitoneal injection of D(−)-salicin reduced TNF-α, IL-1β, and IL-6 levels and significantly increased IL-10 levels in mice with LPS-induced inflammation [129]. In addition, D (−)-salicin was shown to inhibit the infiltration of neutrophils and macrophages into LPS-induced lung tissue, improve the accumulation of nuclear factor erythroid 2-related factor-2 (NRF-2), and reduce oxidative stress [129]. Due to these anti-inflammatory properties, salicylate has been used to treat a number of inflammatory diseases.…”

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 58%

“…Salicylate is a non-selective inhibitor of COX1 and COX2 and induces an anti-inflammatory effect in a variety of diseases [127, 128]. A recent in vitro study has shown that administration of D(−)-salicin down-regulates TNF-α, IL-1β, and IL-6 in LPS-induced inflammatory macrophages [129]. Consistent with this finding, the intraperitoneal injection of D(−)-salicin reduced TNF-α, IL-1β, and IL-6 levels and significantly increased IL-10 levels in mice with LPS-induced inflammation [129].…”

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 99%

“…A recent in vitro study has shown that administration of D(−)-salicin down-regulates TNF-α, IL-1β, and IL-6 in LPS-induced inflammatory macrophages [129]. Consistent with this finding, the intraperitoneal injection of D(−)-salicin reduced TNF-α, IL-1β, and IL-6 levels and significantly increased IL-10 levels in mice with LPS-induced inflammation [129]. In addition, D (−)-salicin was shown to inhibit the infiltration of neutrophils and macrophages into LPS-induced lung tissue, improve the accumulation of nuclear factor erythroid 2-related factor-2 (NRF-2), and reduce oxidative stress [129].…”

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

Yanez

Blanchette

Jabbarzadeh

2018

CPD

View full text Add to dashboard Cite

Tissue engineering offers a promising strategy to restore injuries resulting from trauma, infection, tumor resection, or other diseases. In spite of significant progress, the field faces a significant bottleneck; the critical need to understand and exploit the interdependencies of tissue healing, angiogenesis, and inflammation. Inherently, the balance of these interacting processes is affected by a number of injury site conditions that represent a departure from physiological environment, including reduced pH, increased concentration of free radicals, hypoglycemia, and hypoxia. Efforts to harness the potential of immune response as a therapeutic strategy to promote tissue repair have led to the identification of natural compounds with significant anti-inflammatory properties. This article provides a concise review of the body’s inflammatory response to biomaterials and describes the role of oxygen as a physiological cue in this process. We proceed to highlight the potential of natural compounds to mediate inflammatory response and improve host-graft integration. Herein, we discuss the use of natural compounds to map signaling molecules and checkpoints that regulate the cross-linkage of immune response and skeletal repair.

show abstract

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 58%

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 99%

Section: Natural Anti-inflammatory Compounds To Modulate Inflammatmentioning

confidence: 99%

See 1 more Smart Citation

Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

Yanez

Blanchette

Jabbarzadeh

2018

CPD

View full text Add to dashboard Cite

show abstract

“…Benth.et Hook, which showed significant activity of anti-inflammatory and analgesic, 14,15,16 played an important role in the Fengshiding dropping pill. Furthermore, recent studies have indicated that the extraction of salicin 17,18,19 from Alangium chinense has the antinociceptive and anti-inflammatory activity, and steam distillation of paeonol 20,21,22 from Cynanchum paniculatum has suppressed swelling, inflammatory reaction and cell impairment. The new extraction procedure for Alangium chinense or Cynanchum paniculatum in the Fengshiding dropping pill is definitely worth study in the future.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, based on the common chemical properties of the representative extract of liquiritin and imperatorin (structure shown in Figure 1), we chose ethanol-water combination extraction of liquiritin 2,7,8 and imperatorin 9,10,11 from Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.…”

Section: Introductionmentioning

confidence: 99%

The Optimum Extraction Process for Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook with Orthogonal Design

Duan¹,

Zhai²,

Cao³

et al. 2017

IJPER

View full text Add to dashboard Cite

Background: To develop the optimal extractive technique of the Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook in the Fengshiding dropping pill. Methods: Single factor experiments were carried out on the effect of water-ethanol extraction by the multiple guidelines grading of the dried extract quantity, the contents of liquiritin and imperatorin. Furthermore, orthogonal experimental design was used for the optimization of cross-functional process. The dried extract quantity and the contents of liquiritin and imperatorin were used as targets. The interaction among solid-liquid ratio, ethanol concentration, extraction time and extraction times was investigated by the analysis of variance. Data processing was carried out with the multiple guidelines grading method for optimizing the extraction condition. Results: The optimal extracting condition was founded to be successively 3 decoctions with 12 times of 75% alcohol for 1 h. Conclusion:The optimal process is stable and feasible.

show abstract

NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages

et al. 2015

View full text Add to dashboard Cite

show abstract

D(−)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models

Cited by 36 publications

References 35 publications

Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds

The Optimum Extraction Process for Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook with Orthogonal Design

NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages

Contact Info

Product

Resources

About