D-ring substituted 1,2,3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation

Banday, Abid H.; Shameem, Shameem A; Gupta, B. D.; Kumar, Halmuthur M. Sampath

doi:10.1016/j.steroids.2010.02.015

Cited by 117 publications

(52 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PC-3, DU-145 (карцинома простаты), HCT-15, 502713 (карцинома кишечника), HEP-2 (карцинома печени), A-549 (карцинома лёгкого), SF-295 (глиобластома) [57] (формула 27). Соединения 270, 271, 272, 274, 276, 277 показали высокую антипролиферативную активность, причём соединение 274 было наиболее активно во всех тестируемых клетках.…”

Section: формула 24unclassified

Steroidal Inhibitors of CYP17A1 as a Template For Novel Anti-Cancer Agents Development

Latysheva

Misharin

2018

BMCRM

View full text Add to dashboard Cite

This review deals with studies of researches of novel CYP17A1 steroidal inhibitors and relative compounds published over the last ten years. The review contains six chapters in which novel targets of well-known CYP17A1 inhibirors (abiraterone and galeterone), anti-cancer and anti-proliferative activities of them major metabolites and new synthetic analogs, and in addition another nitrogen-containing androstane and pregnane derivatives are considered. In the review 354 structures of novel steroid derivatives and them anti-cancer efficiency data are considered. Analysis of the literature data allows us to consider steroidal inhibitors of CYP17A1 as multi-target anti-cancer agents with high pharmacological potential.

show abstract

Section: формула 24unclassified

Steroidal Inhibitors of CYP17A1 as a Template For Novel Anti-Cancer Agents Development

Latysheva

Misharin

2018

BMCRM

View full text Add to dashboard Cite

show abstract

“…The triazole produced plant protection fungicides like epoxiconazole, triadimenol, propiconazole, metconazole, cyproconazole, tebuconazole, flusilazole paclobutrazol and tazobactam. Various substituted triazole compounds are responsible for producing antibacterial effects and further modifications can be made on it to enhance their antimicrobial effects [16][17][18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Pharmacological activities of Triazole analogues as antibacterial, antifungal, antiviral agents

Asif¹

2017

Pharm Sci Asia

View full text Add to dashboard Cite

Triazoles and its derivatives possess a great importance in medicinal chemistry and can be used for the synthesis of various compounds with different types of biological activities. The triazole derivatives are possessing divers biological activities such as antibacterial, antifungal, antiviral, antitubercular, anti-inflammatory, analgesic, antitumor, anticonvulsant and some other biological as well as chemical useful compounds. The biological profile of triazole moiety has attracted the attention of many researchers to explore its multiple potential against several biological activities. This article covers the information of some triazoles derivatives having antimicrobial activities. Thus triazole acts as a promising medicinal agent and can be helpful to develop new triazole compounds that could have better efficacy and lesser toxicity.

show abstract

“…In particular, 1,4-disubstituted 1,2,3-triazoles have significant anti-proliferative activity against a wide variety of human cancer cell lines, including those that are multidrug resistant [5][6][7]. Although organic azides are stable against most reaction conditions, compounds of low molecular weight or those containing several azides tend to be explosive and are difficult to handle [8], hence procedures involving generation of the azides in situ followed by azide alkyne cycloaddition have recently been reported [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Facile and efficient sonochemical synthesis of 1,4-disubstituted 1,2,3-triazole derivatives catalyzed by CuI under mild conditions

2013

View full text Add to dashboard Cite

A facile and highly efficient method for regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles in good to excellent yields from in-situ-generated azides and terminal alkynes by Cu(I)-catalyzed 1,3 dipolar cycloaddition (the so-called click reaction), is described. The reaction proceeds smoothly in a 1:1 mixture of water and ethanol at room temperature without any additive. The method is a convenient means of preparation of a wide range of triazoles in a one-pot operation via a three-component reaction.

show abstract

D-ring substituted 1,2,3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation

Cited by 117 publications

References 16 publications

Steroidal Inhibitors of CYP17A1 as a Template For Novel Anti-Cancer Agents Development

Steroidal Inhibitors of CYP17A1 as a Template For Novel Anti-Cancer Agents Development

Pharmacological activities of Triazole analogues as antibacterial, antifungal, antiviral agents

Facile and efficient sonochemical synthesis of 1,4-disubstituted 1,2,3-triazole derivatives catalyzed by CuI under mild conditions

Contact Info

Product

Resources

About