d-Ribose-l-Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase-3 and GFAP Expressions Following Manganese-Induced Neurotoxicity

Akingbade, Grace T.; Ijomone, Omamuyovwi M.; Imam, Aminu; Aschner, Michael; Ajao, Moyosore Salihu

doi:10.1007/s12640-021-00404-3

Cited by 15 publications

(10 citation statements)

References 64 publications

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“…67 Since increased Mn level is associated with oxidative stress. 4,68,69 We further explored sex-dependent oxidative response following Mn accumulation via Hsp70 and Nrf2 modulation. Oxidative stress is a key event in many brain pathologies.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to Mn mainly occurs through the air, 2 food, and drinking water 3 . Following exposure, Mn accumulates in different brain regions, mainly the basal ganglia (which includes the striatum), hippocampus, and cerebral cortex 4–8 . Previous studies found that chronic exposure to Mn led to adverse dose‐dependent effects on neurobehavioral function in rats, with overt morphological changes and neurodegeneration in different brain regions including the hippocampus, striatum, cortex, and cerebellum 4,9–12 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress plays an important role in Mn‐induced toxicity in neurons 4,13 and glia cells 14,15 . Oxidative stress and disrupted redox status are key events in Mn neurotoxicity and likely associated with Mn‐induced mitochondrial dysfunction 1,4 . Heat shock proteins (HSPs) including Hsp70 are molecular chaperones that regulate protein synthesis as well as preserving structural integrity of existing proteins.…”

Section: Introductionmentioning

confidence: 99%

“…status are key events in Mn neurotoxicity and likely associated with Mn-induced mitochondrial dysfunction. 1,4 Heat shock proteins (HSPs) including Hsp70 are molecular chaperones that regulate protein synthesis as well as preserving structural integrity of existing proteins. In pathological conditions, they exhibit several functions, including structural renovation of denatured proteins as well as attenuation of protein aggregation.…”

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confidence: 99%

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Sex‐dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure

Ijomone

Iroegbu

Morcillo

et al. 2022

Environmental Toxicology

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Manganese (Mn), although important for multiple cellular processes, has posed environmental health concerns due to its neurotoxic effects. In recent years, there have been extensive studies on the mechanism of Mn‐induced neuropathology, as well as the sex‐dependent vulnerability to its neurotoxic effects. Nonetheless, cellular mechanisms influenced by sex differences in susceptibility to Mn have yet to be adequately characterized. Since oxidative stress is a key mechanism of Mn neurotoxicity, here, we have probed Hsp70 and Nrf2 proteins to investigate the sex‐dependent changes following exposure to Mn. Male and female rats were administered intraperitoneal injections of MnCl2 (10 mg/kg and 25 mg/kg) 48 hourly for a total of eight injections (15 days). We evaluated changes in body weight, as well as Mn accumulation, Nrf2 and Hsp70 expression across four brain regions; striatum, cortex, hippocampus and cerebellum in both sexes. Our results showed sex‐specific changes in body‐weight, specifically in males but not in females. Additionally, we noted sex‐dependent accumulation of Mn in the brain, as well as in expression levels of Nrf2 and Hsp70 proteins. These findings revealed sex‐dependent susceptibility to Mn‐induced neurotoxicity corresponding to differential Mn accumulation, and expression of Hsp70 and Nrf2 across several brain regions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Sex‐dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure

Ijomone

Iroegbu

Morcillo

et al. 2022

Environmental Toxicology

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Modulatory Role of Curcumin on Cobalt-Induced Memory Deficit, Hippocampal Oxidative Damage, Astrocytosis, and Nrf2 Expression

et al. 2023

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Chemical overexposure is a growing environmental risk factor for many medical issues. Cobalt toxicity from environmental, industrial, and medical exposure, has previously been linked to neurological impairment. Hence, the current study looked into the neuroprotective potential of curcumin, a natural polyphenol contained in spice turmeric, against cobalt-induced neurotoxicity. Adult rats were randomly divided into six groups as follows: control, 40 mg/kg cobalt chloride (CoCl2) only, 240 mg/kg curcumin only, 120 mg/kg or 240 mg/kg curcumin or 100 mg/kg Vitamin C co-administered with CoCl2. The administration was via oral route daily for four weeks. After that, neurobehavioral tests were undertaken to evaluate short-term spatial memory. Biochemical investigation was performed to determine the hippocampal levels of status via measures of SOD, CAT, GST, and LPO). Furthermore, immunohistochemical assessment of the expression of GFAP and Nrf2 in the hippocampus was carried out. In the CoCl2 group, the results showed altered behavioral responses, a decrease in antioxidant activities, increased expression of GFAP and the number of activated astrocytes, and decreased immunoexpression of Nrf2. These effects were mitigated in the Curcumin and Vitamin C treated groups.These results collectively imply that curcumin enhances cognitive functions in rats exposed to cobalt possibly by attenuating oxidative responses, mitigating astrocytosis, and modulating Nrf2 signaling.

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Single-cell transcriptomics analysis of zebrafish brain reveals adverse effects of manganese on neurogenesis

Wang,

Yang,

et al. 2024

Environmental Pollution

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d-Ribose-l-Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase-3 and GFAP Expressions Following Manganese-Induced Neurotoxicity

Cited by 15 publications

References 64 publications

Sex‐dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure

Sex‐dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure

Modulatory Role of Curcumin on Cobalt-Induced Memory Deficit, Hippocampal Oxidative Damage, Astrocytosis, and Nrf2 Expression

Single-cell transcriptomics analysis of zebrafish brain reveals adverse effects of manganese on neurogenesis

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