D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy

Yu, Lexiang; Chen, Yao; Xu, Yong; He, Tao; Wei, Yan; He, Rong

doi:10.18632/aging.102089

Cited by 23 publications

(18 citation statements)

References 93 publications

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“…By assessing the impact of D-ribose on human nonenzymatic glycosylation of myoglobin, Yamamoto and Yamamoto (49) determined that D-ribose may accelerate glycosylation of myoglobin and other proteins more efficiently than D-glucose. Yu et al (62) also suggested that the urine concentration of D-ribose in patients with type 2 diabetes was substantially higher than that of normal individuals, which also indicated high levels of D-ribose in the body of patients with diabetes. In addition, high D-ribose concentrations may also cause chronic diabetes complications by other means.…”

Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

“…Wang et al ( 72 ) also indicated that in alkaline environments, D-ribose may decompose to formaldehyde by the reverse aldol reaction, and that by determining the content of formaldehyde in various parts of mice, it was suggested that formaldehyde produced by D-ribose accumulates in the brain of the mice and that the accumulation of endogenous formaldehyde to pathological concentrations may lead to disturbance of consciousness and cognition. However, it was also hypothesized that accumulation of D-ribose-induced AGEs is an important means underlying the occurrence and development of diabetic encephalopathy ( 62 ). Han et al ( 65 ) reported that D-ribose glycosylation led to the accumulation of AGEs in the nervous system, leading to spatial cognitive impairment and astrocyte-mediated RAGE-dependent inflammation.…”

Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

“…The study by Gheith et al ( 74 ) agreed with this hypothesis and proved that the accumulation of AGEs may lead to neuronal dysfunction and death. According to a recent study, high levels of D-ribose in type 1 diabetes may suggest that D-ribose is involved in complications associated with type 1 diabetes, including encephalopathy ( 62 ). Several of the above studies have indicated possible damage to the nervous system caused by high concentrations of D-ribose in the body and provided an alternate means of understanding the potential pathogenesis of Alzheimer's disease and diabetic encephalopathy.…”

Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

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D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Wang

Xiao

et al. 2021

Exp Ther Med

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The quality of life of patients with certain diseases may be improved through the development of technologies and advancements in pharmacology, with the aim of prolonging their life. However, congestive heart failure (CHF), as well their complications, continue to be the leading cause of disease-associated death. The mechanisms underlying the development and progression of diabetes and CHF have been uncovered in a stepwise manner and the understanding of these mechanisms has improved the management of these diseases, resulting in reduced mortality and morbidity rates; however, CHF remains the leading cause of death worldwide, particularly in developed countries. In the past decades, research has indicated that several supplements and naturally occurring compounds may be used to treat muscle weakness, for cardiac failure management, rehabilitation following myocardial ischemia-reperfusion and various complications of diabetes. D-ribose is an essential component of the respiratory, skeletal and nervous systems and is a popular compound, as its supplementation may have beneficial effects. In the present review, the physiological roles, toxic reactions and the potential use of D-ribose in the management of clinical diseases are summarized. Contents 1. Introduction 2. Physiological roles of D-ribose 3. Clinical applications of D-ribose 4. Potential hazards of high concentrations of D-ribose 5. Conclusions and future perspectives

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Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

Section: Potential Hazards Of High Concentrations Of D-ribosementioning

confidence: 99%

See 1 more Smart Citation

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Wang

Xiao

et al. 2021

Exp Ther Med

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“…Notably, abnormally high levels of D-ribose have been observed in both T1DM (Yu et al, 2019) and T2DM (Su and He, 2014). Since administration of D-ribose induces the yield of Aβ and hyper-phosphorylated tau in the brain (Wu et al, 2015(Wu et al, , 2019Li et al, 2020), D-ribose might be also important for induction of AD.…”

Section: Importance Of Common Modifiers Of Alzheimer's Disease and Tymentioning

confidence: 99%

Connecting Alzheimer’s Disease With Diabetes Mellitus Through Amyloidogenic Evolvability

Ho¹,

Takamatsu

Wada

et al. 2020

Front. Aging Neurosci.

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“…КПГ представляют собой группу молекул числом более 20 [1,2], различных по своим свойствам, включая способность к аутофлуоресценции и образованию поперечных сшивок. КПГ являются важными патогенетическими факторами развития когнитивных нарушений (диабетическая энцефалопа-тия, конформационные болезни мозга) [3][4][5][6]. Структуры некоторых КПГ представлены на рисунке 1.…”

Section: Introductionunclassified

Influence of Certain D-Metals on Formation of Advanced Glycation End Products, Aggregation and Amyloid Transformation of Albumin in Glycation Reaction

Litvinov

Гонтарева

Усмиянова

et al. 2021

Farm. farmakol. (Pâtigorsk)

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The aim of the research is to investigate the influence of the factor of the glycation behavior of bovine serum albumin (BSA) by glucose, and the factor of d-metal cations (nickel (II), cobalt (II), iron (II), iron (III), copper (II) or zinc (II)) presence, on the process of aggregation and the amyloid transformation of BSA and, therefore, to establish the effect of these cations on the rate of the formation of advanced glycation end products (AGEs), and the intensity of fluorescence of the amino acids tyrosine and tryptophan.Materials and methods. Reagents in the glycation are: glucose (at the final concentration of 0.36 M), BSA (at the final concentration of 1 mg/ml), deionized water, one of the d-metal cations, i. e. nickel (II), cobalt (II), iron (II), iron (III), copper (II) or zinc (II) (in the form of chloride, sulfate or nitrate salts, at the final concentration of 40 μM). The conditions for the glycation reaction are the incubation for 24 hours at the temperature of 60°C. The influence of two factors (the factor of the glycation reaction and the factor of a d-metal ion presence in the reaction medium) on the concentration of glycation end products (AGEs) formed during the glycation reaction, on the fluorescence intensity of the amino acids tryptophan and tyrosine, on the aggregation of BSA, and on the ability of BSA to the amyloid transformation under the described conditions, have been studied.Results. It was found out that the studied factors have a statistically significant effect on the considered parameters. The highest activity was found for the copper ion (II), which intensifies the formation of the AGEs in the samples where glycation occurs, reduces the fluorescence intensity of the amino acids’ tryptophan and tyrosine (independently and increasing the effect against the background of glycation). Besides, it independently causes the aggregation of BSA hereby intensifying the effect against the background of glycation, it independently causes the amyloid transformation of BSA enhancing the effect against the background of glycation. The above-listed effects were the least pronounced in the reaction media with the addition of nickel (II) or cobalt (II). These cations reduce the rate of the AGEs formation, do not cause the formation of protein aggregates. In the presence of glucose, nickel (II) weakly suppresses the fluorescence intensity of tryptophan and tyrosine, and slightly enhances the amyloid transformation of BSA. Cobalt (II) slightly inhibits the amyloid transformation of BSA. In terms of the severity and nature of the effects, the iron (II), iron (III) and zinc (II) cations occupy an intermediate position between copper (II), on the one hand, and nickel (II) and cobalt (II), on the other hand, combining the influence on the AGEs formation, the intensity of fluorescence of tryptophan and tyrosine, the aggregation and amyloid transformation of BSA. In the absence of glucose, the ability of zinc (II) to induce the formation of protein aggregates turned out to be the highest, and its ability to stimulate the amyloid transformation of BSA corresponded to that of copper (II).Conclusion. The presence of d-metal cations affects the rate of the AGEs formation in the glycation reaction, affects the rate of the BSA amyloid transformation and the protein aggregates formation. Among such ions as nickel (II), cobalt (II), iron (II), iron (III), copper (II) and zinc (II), copper (II) ions turned out to be the most active in their ability to accelerate the AGEs formation, suppress the fluorescence of tryptophan and tyrosine, enhance the aggregation and amyloid transformation of BSA in the glycation reaction. The least manifestation of these properties is observed for nickel (II) and cobalt (II) ions.

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D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy

Cited by 23 publications

References 93 publications

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Connecting Alzheimer’s Disease With Diabetes Mellitus Through Amyloidogenic Evolvability

Influence of Certain D-Metals on Formation of Advanced Glycation End Products, Aggregation and Amyloid Transformation of Albumin in Glycation Reaction

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