D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five Bougainvillea spectabilis Willd. Cultivars

Abo-Elghiet, Fatma; Ahmed, Amal H.; Aly, Hanan F.; Younis, Eman; Rabeh, Mohamed A.; Alshehri, Saad Ali; Alshahrani, Khalid; Mohamed, Shaza A.

doi:10.3390/ph16071008

Cited by 4 publications

References 60 publications

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D-Pinitol extends antioxidant activity and longevity of Caenorhabditis elegans via insulin-like signaling pathway

Shi,

Liu,

et al. 2023

Preprint

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D-Pinitol is a cyclic polyol mainly derived from pinaceae and legume. It has the functions of regulating blood glucose balance, anti-inflammation and cardiovascular protection. D-Pinitol is a 3-methoxy analogue of D-chiral-inositol. In our previous study, we found that D-chiral-inositol could prolong the lifespan of Caenorcaditis elegans. D-Pinitol and D-chiral-inositol are commonly used in the treatment of diabetes and polycystic ovary syndrome. We therefore proceeded to investigate the anti-aging effect of D-Pinitol in Caenorhabditis elegans. Our findings demonstrate that D-Pinitol significantly extends the lifespan of Caenorhabditis elegans by 25.41%, enhances body bend frequency, and reduces lipofuscin accumulation. Moreover, it effectively delays neurodegenerative disease development in this model organism. Mechanistically, D-Pinitol promotes gene expression related to insulin-like signaling pathway in Caenorhabditis elegans while also reducing malondialdehyde levels and increasing total antioxidant capacity as well as superoxide dismutase and catalase activities. Consequently, our results indicate that through activation of the insulin-like signaling pathway, D-Pinitol improves both antioxidant capacity and lifespan in Caenorhabditis elegans—a testament to its remarkable antioxidative properties—thus highlighting the significance for further research on this compound.

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D-Pinitol extends antioxidant activity and longevity of Caenorhabditis elegans via insulin-like signaling pathway

Shi,

Liu,

et al. 2023

Preprint

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Phytochemistry, Anti-Tyrosinase, and Anti-Diabetes Studies of Extracts and Chemical Constituents of Dicerothamnus rhinocerotis Leaves

Watti,

Yalo,

Sharma

et al. 2024

Chemistry

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Dicerothamnus rhinocerotis (L.f.) Koekemoer, also known as rhinoceros bush and previously called Elytropappus rhinocerotis (L.f.) Less., is from the Asteraceae plant family. The plant is traditionally used to treat indigestion, stomach ulcers, influenza, and diarrhea. This study was aimed at investigating the phytochemistry, anti-glucosidase, anti-amylase, and anti-tyrosinase effects of D. rhinocerotis as research in this area is limited. The air-dried plant materials were macerated in 80% methanol (MeOH) and fractionated between hexane, dichloromethane (DCM), ethyl acetate (EtOAc), and butanol (BuOH). Column chromatography on silica gel was employed for the isolation of the compounds. A total of six compounds (1–6) were isolated from the fractions viz. acacetin (1), 15-hydroxy-cis-clerodan-3-ene-18-oic-acid (2), acacetin-7-glucoside (3), pinitol (4), apigenin (5), and β-sitosterol-3-O-glycoside (6). Compounds 2–4 and 6 are reported for the first time from this plant. Among the different fractions, the BuOH and EtOAc fractions had strong tyrosinase inhibitory activities with IC50 values of 13.7 ± 1.71 and 11.6 ± 2.68 µg/mL, respectively, while among the isolated compounds, apigenin (5) had the strongest inhibitory activity, with an IC50 of 14.58 µM, which competes favorably with Kojic acid (17.26 µM). The anti-glucosidase assay showed good activity in three of the fractions and compound 5, while the anti-amylase assays did not show significant inhibition activity.

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Antioxidant Activity of Bougainvillea spectabilis Bracts as an Alternative to Nitrites in Cooked Pork Ham

Ferreira,

Rodriguez,

Sánchez-Ortega

et al. 2024

Foods

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In this study, the impact of incorporating Bougainvillea spectabilis powder into ham formulation as a potential color replacement for nitrites was evaluated. Three drying methods were proposed to preserve the antioxidant properties of bougainvillea: foam-mat drying, air drying, and oven drying. Antioxidant assays (DPPH, ABTS, and FRAP) assays revealed that the presence of bougainvillea powders enhanced the antioxidant properties and maintained the stability of the ham over 8 weeks of storage at 4 °C. In addition, total polyphenolic content and presence of thiobarbituric acid reactive substances (TBARS) were evaluated and showed higher and lower scores, respectively, in the samples with the incorporation of bougainvillea compared to the control samples, suggesting their potential to replace nitrite salts by providing natural antioxidant protection. Sensorial analysis also revealed no significant differences in sensory attributes in hams with 0.1% bougainvillea powder compared to nitrite samples. The incorporation of the bougainvillea powders in the ham formulation improved the sensorial attributes and consumer overall acceptance even after 8-week cold storage at 4 °C.

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D-Pinitol Content and Antioxidant and Antidiabetic Activities of Five Bougainvillea spectabilis Willd. Cultivars

Cited by 4 publications

References 60 publications

D-Pinitol extends antioxidant activity and longevity of Caenorhabditis elegans via insulin-like signaling pathway

D-Pinitol extends antioxidant activity and longevity of Caenorhabditis elegans via insulin-like signaling pathway

Phytochemistry, Anti-Tyrosinase, and Anti-Diabetes Studies of Extracts and Chemical Constituents of Dicerothamnus rhinocerotis Leaves

Antioxidant Activity of Bougainvillea spectabilis Bracts as an Alternative to Nitrites in Cooked Pork Ham

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