d-Methionine attenuated cisplatin-induced vestibulotoxicity through altering ATPase activities and oxidative stress in guinea pigs

Cheng, Po‐Wen; Liu, Shing‐Hwa; Young, Yi‐Ho; Lin‐Shiau, Shoei‐Yn

doi:10.1016/j.taap.2006.02.014

Cited by 30 publications

(36 citation statements)

References 54 publications

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“…56,57 Furthermore, oxidative stress is closely involved in cisplatin vestibulotoxicity, and, therefore, antioxidants have been proposed to be useful in preventing cisplatin vestibulotoxicity. 55 In the present study, we clearly demonstrated that the secretion and expression of the proinflammatory cytokines TNF-a, IL-1b, and IL-6 were increased in UB/UE-1 cells following the addition of cisplatin in vitro and in the cristae ampullae and utricle of mice in vivo following the peritoneal injection of cisplatin. In addition, our unpublished data demonstrate that proinflammatory cytokines are directly involved in the death of UB/UE-1 utricular cells following cisplatin exposure.…”

Section: Discussionsupporting

confidence: 64%

“…There are in vitro and in vivo studies supporting the hypothesis that cisplatin can induce mitochondrial injury by inhibiting the Na 1 , K 1 -ATPase, and/or Ca 21 -ATPase activities of renal, 53 cochlear, and vestibular tissues. 54,55 Therefore, it is thought that mitochondrial injury caused by the inhibition of both ATPase activities might have a role in the pathogenesis of cisplatininduced vestibular dysfunction. In addition, nitric oxide synthase and apoptosis were induced in the vestibule of guinea pigs after cisplatin exposure.…”

Section: Discussionmentioning

confidence: 99%

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Role of proinflammatory cytokines in cisplatin‐induced vestibular hair cell damage

Kim

Lee

et al. 2008

Head & Neck

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Role of proinflammatory cytokines in cisplatin‐induced vestibular hair cell damage

Kim

Lee

et al. 2008

Head & Neck

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“…Their cochleotoxic potential has been reported in some studies, not so the vestibular damage [5,10,13,[15][16][17] . It is remarkable that vestibulotoxicity and cochleotoxicity do not always simultaneously occur.…”

Section: Discussionmentioning

confidence: 95%

“…Labyrinthine damage induced by other drugs has also been reported [4][5][6][7][8][9][10]13] . This is the case for cisplatin, a chemotherapeutic agent that causes vestibular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…This is the case for cisplatin, a chemotherapeutic agent that causes vestibular dysfunction. In animal models, cisplatin induces vestibulotoxicity by altering ATPase activities (cisplatin inhibits ATPase activities) and increasing oxidative stress in labyrinths [13] . It is well known that glutathione and glutathione-related enzymes protect against oxidative cell injury caused by free radicals.…”

Section: Discussionmentioning

confidence: 99%

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Instability Due to Drug-Induced Vestibulotoxicity

Sánchez-Sellero

Soto-Varela²

2016

Int Adv Otol

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OBJECTIVE:The therapeutic use of ototoxic drugs is relatively common, particularly in patients with severe diseases. It is likely that disturbances of balance in these patients are underestimated by clinicians. MATERIALS and METHODS:The purpose of this study was to identify drugs involved in the vestibulotoxic origin of instability in a group of 18 patients. RESULTS:Six patients showed both cochlear and vestibular damage, while 12 were affected only by posterior labyrinthine damage. Four groups of drugs were identified: antibiotics (nine patients), cytostatics (four), anti-tuberculosis medicinal products (three), and other drugs (two). Cytostatics were involved in many cases studied, a fact scarcely reported before. CONCLUSION:It is important to ensure an early diagnosis to prevent ototoxic effects induced by drugs. We propose that patients receiving potential ototoxic drugs undergo cochlear and vestibular assessments. Further, we recommend that patients with instability undergo vestibular rehabilitation.

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Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer

et al. 2019

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The protective antioxidant activity of acetylcysteine (NAC) against toxicity due to cisplatin has been reported in experimental models; however, its efficacy in patients has not been elucidated. The aim of this study was to investigate the possible protective effect of NAC on cisplatin‐induced toxicity and the effect of NAC on clinical response and oxidative stress in patients treated for head and neck cancer. This was a randomized, double‐blind, placebo‐controlled trial conducted in patients receiving high‐dose cisplatin chemotherapy concomitant to radiotherapy. Patients were randomly assigned to groups and received: (a) 600 mg NAC syrup, orally once daily at night for 7 consecutive days or (b) placebo, administered similarly to NAC. Nephro‐, oto‐, hepato‐, myelo‐, and gastrointestinal toxicities, clinical responses, and plasma and cellular markers of oxidative stress were evaluated. Fifty‐seven patients were included (n = 28, NAC arm; and n = 29, placebo arm). A high prevalence of most types of toxicities was observed after cisplatin chemotherapy; however, the parameters were similar between the two groups. There was a predominance of partial response to treatment. In the cellular and plasmatic oxidative stress analyses, minor differences were observed. Overall, there was no statistically significant difference between the groups for all outcomes. These findings show that low‐dose oral NAC does not protect patients with head and neck cancer from cisplatin‐induced toxicities and oxidative stress. The antitumor efficacy of cisplatin was apparently not impaired by NAC.

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d-Methionine attenuated cisplatin-induced vestibulotoxicity through altering ATPase activities and oxidative stress in guinea pigs

Cited by 30 publications

References 54 publications

Role of proinflammatory cytokines in cisplatin‐induced vestibular hair cell damage

Role of proinflammatory cytokines in cisplatin‐induced vestibular hair cell damage

Instability Due to Drug-Induced Vestibulotoxicity

Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer

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