D-Homo-steroids. Part I. Derivatives monosubstituted in ring D

Abstract

~-Homo-5cr-androstan-17a-one, -1 i'-one, and -1 6-one, and the corresponding epimeric pairs of alcohols and acetates have been prepared. These are valuable reference compounds quasi-enantiomeric to derivatives monosubstituted in ring A. N.m.r. data are considered ; 0.r.d. and c.d. curves have been treated elsewhere.

A biochemical logic approach to biomarker-activated drug release

“…Rather, -14 -increasing it leads to slower concentration buildup at the distance x from the cuvette bottom. Note that for larger times than those of our experiment, the concentration at x will actually decrease, to zero if there is no reflecting liquid-column top -as assumed for Equation (2). Our time-dependence form for the remaining dye-containing core radius is sketched in the inset in Figure 6.…”

“…The design of new controlled-release chemical systems has received considerable attention due to their advantages in various areas including fragrance release, 1 selfhealing materials 2,3 and particularly for delivery of bioactive substances (drugs, vitamins, nutrients, contrasts for imaging, genes, etc.) in various biomedical applications.…”

“…: Results of fitting the time-dependent data presented in Figure 5 according to Equation (2). Note that all the parameters but the fitted values of t 0 and t c are known independently.…”

Structural Studies of Hydroxylated D‐homo‐5α‐androstanes by 1H NMR decoupling difference techniques

“…3P-Acetoxy-Dhomo-5a-androstan-17a-one (l), 3a-hydroxy-~-homo-5a-androstan-17a-one (2), 3aacetoxy-~-homo-5a-androstan-17a-one (3) and Dhomo-5a-androstane-3,17a-dione (4) were prepared according to published procedures. [16][17][18] 3/3,11 (Y -Dihydroxy-~-homo-5a-androstan-17a-one (13), 3a-acetoxy-~-homo-5a-androstane-7,11,17a-trione (7), 3a-acetoxy-l~,8~-dihydroxy-~-homo-5aandrostan-17a-one (8), lP, 3P,7/3-trihydroxy-~-homo-5a-androstan-17a-one (9), 3P,7P-dihydroxy-~-horno-5a-androstan-l7a-one (lo), 1P, 3P-dihydroxy-~-homo-5a-androstan-7,17a-dione (11), 7a,9a-dihydroxy-~homo-5a-androstane-3,17a-dione (14) and 9ahydroxy-~-homo-5~-androstane-3,7,17a-trione (16) were some of the compounds isolated and identified from the microbial transformations of D-homosteroids by the fungus Cunninghamella elegans, and their preparation is described e1~ewhere.l~…”

Sensitized Aliphatic Fluorination Directed by Terpenoidal Enones: A “Visible Light” Approach

“…Mp = 142−145 °C. Starting Material for Compound 10 (3β-Acetoxy-D-homo-5αandrost-16-en-17a-one 47,48 ). Prasterone acetate (5.0 g, 15 mmol) was dissolved in EtOH (150 mL) and treated with KCN (31.5 g, 484 mmol) while stirring.…”