D-dimer local expression is increased in symptomatic patients undergoing carotid endarterectomy

Krupiński, Jerzy; Catena, Esther; Miguel, Marta; Domènech, Pere Pascual i; Vila, Ramon; Morchón, Sergio; Rubio, Francisco; Cairols, Marc; Slevin, Mark; Badimon, Lina

doi:10.1016/j.ijcard.2006.02.014

Cited by 15 publications

(10 citation statements)

References 38 publications

(37 reference statements)

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“…Giannitsis et al [26] already demonstrated the relationship between haemostatic factors and coronary artery diseases. Krupinski et al [27] found an increased value of D-dimers in patients undergoing carotid endarterectomy: unstable plaques, in fact, seemed to show a higher fibrin intraplaque turnover able to induce an augmentation of D-dimers products, thus making D-dimers a surrogate marker of plaque instability. Clinical data recently indicated an association between elevated levels of D-dimers and the risk of subsequent clinical manifestations of cardiovascular disease [28].…”

Section: Discussionmentioning

confidence: 99%

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Ciccone

Scicchitano

Salerno

et al. 2013

BioMed Research International

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Aim. To evaluate the influence of selected maternal and neonatal characteristics on aorta walls in term, appropriately grown-for-gestational age newborns. Methods. Age, parity, previous abortions, weight, height, body mass index before and after delivery, smoking, and history of hypertension, of diabetes, of cardiovascular diseases, and of dyslipidemia were all assessed in seventy mothers. They delivered 34 males and 36 females healthy term newborns who underwent ultrasound evaluation of the anteroposterior infrarenal abdominal aorta diameter (APAO), biochemical profile (glucose, insulin, total cholesterol, HDL and LDL cholesterol, triglycerides, fibrinogen, and D-dimers homeostasis model assessment [HOMAIR]index), and biometric parameters. Results. APAO was related to newborn length (r = +0.36; P = 0.001), head circumference (r = +0.37; P = 0.001), gestational age (r = +0.40, P = 0.0005), HOMA index (r = +0.24; P = 0.04), and D-dimers (r = +0.33, P = 0.004). Smoke influenced APAO values (odds ratio: 1.80; confidence interval 95%: 1.05–3.30), as well as diabetes during pregnancy (r = +0.42, P = 0.0002). Maternal height influenced neonatal APAO (r = +0.47, P = 0.00003). Multiple regression analysis outlined neonatal D-dimers as still significantly related to neonatal APAO values. Conclusions. Many maternal and neonatal characteristics could influence aorta structures. Neonatal D-dimers are independently related to APAO.

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Section: Discussionmentioning

confidence: 99%

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Ciccone

Scicchitano

Salerno

et al. 2013

BioMed Research International

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“…Patients undergoing endarterectomy for symptomatic disease with ulcerated complicated carotid plaques had higher intraplaque D-dimer levels. Furthermore, hypercholesterolaemic patients with ulcerated complicated plaques had significantly higher fibrin turnover indicating greater plaque procoagulant activity and risk for symptomatic disease [74] . Markers of plaque remodelling may be related with the occurrence of symptomatic disease.…”

Section: Relationship Between Plaque Constituents and Occurrence Of Smentioning

confidence: 99%

Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease?

Slevin¹,

Wang²,

Font³

et al. 2008

Pathobiology

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Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture.

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“…However, it is difficult to clearly define whether a plaque is stable or vulnerable by currently available techniques, although, in recent years advances in MRI have improved our ability to identify carotid plaque morphology (6). More recently, vulnerable atherosclerotic plaques have been characterized by their expression of high numbers of inflammatory cells (7)(8)(9)(10) and in vivo imaging of the current metabolic, dynamic state of the plaque would help to identify those patients at highest risk of ischemic stroke (11)(12). In a clinical situation, number of patients suffering from stroke or transient ischemic attack (TIA)…”

Section: Introductionmentioning

confidence: 99%

Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET

Ma¹,

Fernández²,

Carvajal³

et al. 2009

Front Biosci

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It is not clear if 18FDG-PET can be useful for detection of inflammation in low to moderate carotid stenosis. We studied 15 patients scheduled for endarterectomy with contralateral carotids with less than 50% stenosis. 18-FDG-PET was performed prior to CEA and 3 months following surgery. FDG-uptake values were calculated based on maximum standardized uptake value (SUV) and corresponding uptake ratios. We confirmed by CD68 macrophage staining that FDG accumulation corresponds to active inflammation (R=0.8 p less than 0.005). We found significant correlation between the FDG-uptake in the carotids scheduled for CEA and contralateral carotids with low to moderate stenosis (R=0.9 p less than 0.001). The FDG uptake ratio in the contralateral arteries remained stable on the follow-up imaging (1.15+/-0.2 vs. 1.14+/-0.1, R=0.7 p=0.006). We did not find correlation between FDG uptake and symptomatic or asymptomatic patients, degree of carotid stenosis and vascular risk factors. This is a prospective, preliminary in vivo study demonstrating that low to moderate carotid atherosclerosis can be detected using 18-FDG-PET imaging and highlights the truly systemic nature of atherosclerosis.

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D-dimer local expression is increased in symptomatic patients undergoing carotid endarterectomy

Cited by 15 publications

References 38 publications

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Atherothrombosis and Plaque Heterology: Different Location or a Unique Disease?

Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET

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