D-Dimer levels are correlated with disease activity in Crohn's patients

Zhang, Ruoyu; Guo, Zhen; Yang, Wei; Zhu, Zhendong; Kong, Wanzhong; Zheng, Sujie; Jiang, Lei; Fei, Xianming; Chen, Yanxia; Liu, Jinlin

doi:10.18632/oncotarget.19250

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…Most of the studies have shown that D-dimer levels were the same/increased in CD patients compared with healthy controls [9,11,28]. Furthermore, some studies found D-dimer level was higher in patients with active disease compared with inactive disease [7,29], demonstrating that D-dimer was related to the disease status. However, our study found that the D-dimer levels were actually decreased in CD patients.…”

Section: Altered Turnover Of Fibrinogen In CD Patientsmentioning

confidence: 99%

Serological Assessment of the Quality of Wound Healing Processes in Crohn’s Disease

Sun

Karsdal

Mortensen

et al. 2019

JGLD

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Background & Aims: Crohn’s disease (CD) is a chronic inflammatory condition characterized by continuous mucosal damage and ongoing wound healing of the intestines. The fibrinolytic system is involved in early parts of the wound healing process. Fibrin is a key mediator of primary blood clot formation and is formed by cross-linking of fibrinogen. To gain insights into the dynamics of wound healing in CD patients we investigated the conversion of fibrinogen into fibrin by the pro-peptide FPA, the amount of factor XIII cross-linked fibrin and total fibrin clot. Methods: Serum samples of 35 CD patients, 15 non-inflammatory bowel disease (non-IBD) patients and 39 age-matched healthy controls were analyzed for three novel neo-epitope markers: D-fragment and D-dimer, reflecting the degradation of total fibrin clot and factor XIII cross-linked fibrin, as well as FPA, reflecting synthesis of fibrin. Results: Crohn’s disease patients had a significantly lower D-dimer level (p=0.0001) compared to healthy controls. Crohn’s disease and non-IBD patients had a significantly higher level of FPA (p<0.0001) and D-fragment/D-dimer ratio (p<0.0001 and p=0.02). FPA, D-dimer and D-fragment/D-dimer ratio could distinguish CD patients from healthy controls with area under the curve of 0.92 (95% CI 0.83-0.97), 0.78 (95% CI 0.67-0.87) and 0.85 (95% CI 0.75-0.93), respectively. Conclusion: Wound healing parameters were clearly changed in CD patients. FPA levels were higher in CD patients as compared to healthy controls, indicating more ongoing wound healing. D-dimer levels were lower in CD patients than in healthy controls, indicating impaired wound healing due to poor quality of factor XIII cross-linked fibrin and clot resolution.

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Section: Altered Turnover Of Fibrinogen In CD Patientsmentioning

confidence: 99%

Serological Assessment of the Quality of Wound Healing Processes in Crohn’s Disease

Sun

Karsdal

Mortensen

et al. 2019

JGLD

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“…In our study D-dimer had good predictive value for 30-day all-cause mortality only in the subgroup of patients with persistent provoked PE. This result might be partly explained as active malignant disease, autoimmune diseases and other severe comorbidities predominate in this subgroup of patients and it is well-known that in these cohorts of patients D-dimer per se is the predictive factor for mortality [16][17][18].…”

Section: Discussionmentioning

confidence: 91%

Different predictive value for short-term all-cause mortality with commonly used biomarkers regarding the cause of pulmonary embolism

et al. 2021

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Background/Aim. The evaluation of blood levels of cardiac troponin-I (cTnI), D-dimer, B-type natriuretic peptide (BNP) and C-reactive protein (CRP) at admission and during the treatment of pulmonary embolism (PE) are the part of routine diagnostic process and estimation of mortality risk. The aim of this study was to evaluate the predictive value of these biomarkers at admission for all-cause 30-day mortality in consecutive PE patients regarding whether they classified as spontaneous, transiently provoked and permanently provoked PE. Methods. This retrospective analysis is gained from the data of 590 PE patients from the Serbian University Multicenter Pulmonary Embolism Registry (SUPER). Patients had at least one of these biomarkers (BNP, CRP, cTnI and D-dimer) measurements during the first 24 hours from the admission. Results. ROC curve analyses demonstrated that BNP had the highest prognostic accuracy for 30-day mortality in patients (N=219) who had data for all examined biomarkers. BNP provided an AUC of 0.785 (p<0.001). Separately BNP had the highest c-statistic for all three groups of patients. CRP had modest predictive value for the 30-day all-cause mortality in the group with transient provoked PE. Troponin I had very modest predictive value for the 30-day all-cause mortality only in patients with spontaneous PE and D-dimer was very weak predictor of this end-point only in patients with persistent provoked PE. Conclusion. Patients with spontaneous, transient provoked and persistent provoked PE have significantly different profile of blood biomarkers level with different prognostic significance for early all-cause mortality.

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“… 34 , 38 , 41 With respect to D-dimer levels, studies are more consistent, reporting higher values in IBD, mostly in active disease. 14 , 39 , 42 …”

Section: Discussionmentioning

confidence: 99%

“…34,38,41 With respect to D-dimer levels, studies are more consistent, reporting higher values in IBD, mostly in active disease. 14,39,42 Concerning CD and UC differences, some series reported higher activity of factor VII in CD patients, 34 while UC patients showed higher values of factor X. 2 In other series, UC patients seemed to have higher PT and higher factor V and VIII levels, but DC patients presented with increased levels of plasminogen.…”

Section: Coagulation Cascade and Fibrinolytic System In Ibdmentioning

confidence: 98%

Inflammatory bowel disease and thromboembolic events: a c’lot to learn

Carvalho

Pinho

Cancela

et al. 2022

Therap Adv Gastroenterol

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Background: Inflammatory bowel disease (IBD) is associated with a variety of extraintestinal manifestations including arterial and venous thromboembolism. Research evidences that IBD patients have about a 2- to 3-fold increase in the risk of venous thromboembolism when compared with the general population. Objectives: We intended to evaluate the coagulation parameters and the prevalence of thromboembolic events (TE) in IBD patients. It was also our aim to investigate the correlation between coagulation parameters and disease phenotype and activity in this population. Methods: This single center prospective observational study was performed between November 2016 and April 2020. The cohort included patients with 18 years of age or older, diagnosed with IBD and followed at a gastroenterology consultation, during a follow-up period of 36 months. Patients were evaluated in terms of IBD type, extent and disease behavior, clinical scores of IBD activity, medication, smoking history, family and personal history of TE, coagulation parameters, fecal calprotectin levels, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hospitalization due to TE, IBD-related hospitalization or surgery, pregnancy, or diagnosis of malignancy. Results: The study included 149 IBD patients (67 males and 82 females). Coagulation parameters were similar in CD and UC patients and only plasminogen was increased in CD patients [97.4 (17.0) versus 91.6 (13.3), p = 0.035], when comparing with UC patients. The determined values were in the range of the reference values described in literature for the standard population. During the follow-up period, none of the patients experienced a TE that demanded hospitalization. Conclusion: In our study, acquired and inherited risk factors for TE and changes in coagulation parameters did not show to influence prothrombotic predisposition in IBD patients. As such, the clinical relevance of measuring coagulation parameters in this population is questionable. Trial Registry: NCT05162339 (ClinicalTrials.gov ID).

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D-Dimer levels are correlated with disease activity in Crohn's patients

Cited by 8 publications

References 23 publications

Serological Assessment of the Quality of Wound Healing Processes in Crohn’s Disease

Serological Assessment of the Quality of Wound Healing Processes in Crohn’s Disease

Different predictive value for short-term all-cause mortality with commonly used biomarkers regarding the cause of pulmonary embolism

Inflammatory bowel disease and thromboembolic events: a c’lot to learn

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