D‐dimer level in liver transplant recipients on the first day after surgery is correlated with postoperative thrombosis recurrence

Zhang, Qun; Guo, Renyong; Chen, Yu

doi:10.1002/jcla.22646

Cited by 3 publications

(5 citation statements)

References 37 publications

(41 reference statements)

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“…In an adult study, Zhang et al [4] reported that D-dimer level on the first day after liver transplant is related to thrombosis recurrence and is an independent risk factor for postoperative thrombosis recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies reported the relation of D-dimer to the occurrence of vascular thrombosis post-liver transplantation (LT) [4]. However, it is known that there are many changes in the hemostatic system in hepatic patients [5].…”

Section: Introductionmentioning

confidence: 99%

“…The level of D-dimer post-LT in children was not described before. Knowing D-dimer kinetics in pediatric recipients post-LT may help predict early thrombosis, either recurrent or de novo [4,6]. In the present study, we aimed to report the post-LT D-dimer level in pediatric recipients to understand its early post-operative behavior.…”

Section: Introductionmentioning

confidence: 99%

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D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children

Darwish,

Adawy,

Saber

et al. 2024

IJG

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Background/Objective: D-dimer, a soluble fibrin degradation product, is used to be a marker of vascular thrombosis. However, it has been reported to be elevated in different pathological conditions other than thrombosis. Moreover, its pattern post-liver transplantation (LT) in children is not known. So, we aimed to report its pattern within the first-month post-LT in children and its level in different early post-LT complications. Methods: It is a retrospective observational cohort study in which 52 children who underwent living-related liver transplantation (LRLT) were included. All the available clinical, imaging, and laboratory data including D-dimer level were collected from the patients' files. Those who developed complications within the first post-LT month were assigned to the complication group (n=41), and others were assigned to the non-complication group (n=11). Results: D-dimer level pre-LT ranged from 0.12-16.41 mg/l, with no significant difference between the complication and non-complication groups. Postoperatively, the D-dimer levels were elevated and did not normalize till the postoperative day (POD) 30. The minimum reported level was 1.2 mg/l on POD0 while the maximum one was 33.12 mg/l on POD12. There were no significant differences between the complication and non-complication groups about the D-dimer level from the pre-LT day till the POD30 (p>0.05). The D-dimer level at the onset of the different complications showed no significant difference among the thrombotic, ACR, and the other complication subgroups (p=0.748). Moreover, the vascular thrombosis subgroup didn’t show a significant difference between the D-dimer level before- and at the onset of thrombosis (p=0.480). Conclusion: D-dimer is non-specifically elevated within the 1<sup>st</sup>-month post-LRLT in children with no clear trend. Moreover, it doesn’t normalize till the end of the 1<sup>st</sup> post-LT month. Being high early postoperatively doesn't necessarily indicate vascular thrombosis or other complications but rather the nature of the transplantation circumstances.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children

Darwish,

Adawy,

Saber

et al. 2024

IJG

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“…19 We summarized the results from previous studies that investigated the cutoff DD and/or SFMC levels to detect VTE and the results of the present study (Table 4). [20][21][22][23][24][25][26] Clinical trials on anticoagulant therapy before the detection of VTE were excluded. Although there were several studies in the field of orthopedics, only three studies, which were conducted in patients who underwent surgery for portal hypertension or liver transplantation, 21,23,26 have been reported in the field of gastroenterological surgery.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

“…[20][21][22][23][24][25][26] Clinical trials on anticoagulant therapy before the detection of VTE were excluded. Although there were several studies in the field of orthopedics, only three studies, which were conducted in patients who underwent surgery for portal hypertension or liver transplantation, 21,23,26 have been reported in the field of gastroenterological surgery. In addition, no study has been conducted on the serum DD and/or SFMC level in patients who underwent HBP surgery.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Asymptomatic Venous Thromboembolism After Hepatobiliary–Pancreatic Surgery: Early Detection Using D‐dimer and Soluble Fibrin Monomer Complex Levels

Hayashi

Shimizu

Koyama

et al. 2021

Annals of Gastroent Surgery

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Aim The aim was to investigate the usefulness of a preemptive management strategy that includes monitoring serum D‐dimer (DD) and soluble fibrin monomer complex (SFMC) levels for early detection and treatment of venous thromboembolism (VTE) after hepatobiliary–pancreatic (HBP) surgery. Methods Overall, 678 patients who underwent HBP surgery between January 2010 and March 2020 were enrolled. Patients with increased postoperative serum DD or SFMC levels underwent contrast‐enhanced computed tomography, and those with VTE received anticoagulant agents. The VTE risk factors were investigated using multivariable analysis. Postoperative changes in DD and SFMC levels were verified, and their ability to identify VTE was evaluated using receiver operating characteristic (ROC) analysis. Results VTE developed in 83 patients (12.2%), and no symptomatic VTE or death due to VTE was observed. Multivariable analysis identified female sex (odds ratio [OR] 2.26; 95% confidence interval [CI] 1.41–3.60; P < .001) and surgery duration of ≥401 min (OR 2.07; 95% CI 1.27–3.35; P < .001) as independent risk factors for VTE. Maximum serum DD and SFMC levels in patients who developed VTE were significantly higher than those in patients without VTE (DD, 15.1 vs 8.9 μg/mL, P < .001; SFMC, 18.0 vs 10.2 μg/mL, P < .001, respectively). Both DD (n = 678) and the combination of DD and SFMC levels (n = 230) showed a good ability to detect VTE (area under the ROC curve, 0.804 and 0.761, respectively). Conclusion Our preemptive strategy of monitoring serum DD and SFMC levels enables early detection and treatment intervention of VTE after HBP surgery.

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Comparison and Risk factors of early and late pulmonary embolism in patients after major cancer surgery

Li,

Zhao,

Zhao

et al. 2023

Preprint

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Background Postoperative pulmonary embolism (PE) is a severe complication in patients underwent major cancer surgery. We assume the pathogeny of early and late PE are different, and design a retrospective study to examine the potential predisposing factors for early and late postoperative PE. MethodsWe investigated patients underwent major cancer surgery in Sichuan Cancer Hospital from April 2016 to May 2022. Postoperative PE was divided into early and late phase by three days after operation. Early PE patients and late PE patients were compared to non-PE postoperative patients in a 1-2 ratio, matched for age (± 3 years), type of cancer and cancer site. Logistic regression analysis and least absolute shrinkage and selection operator (LASSO) regression analysis were used to identify risk factors of early PE and late PE respectively. Results There were thirty-six patients were collected as early PE group, and 46 patients were allocated to late PE. There were no significant differences in demographics, cancer type, cancer stage, PE location and mortality between early PE group and late PE group. After LASSO logistic regression, early postoperative PE was significantly associated with Body mass index (BMI), intraoperative hypotension time (IHT) and postoperative D-dimer value (P<0.05). Postoperative D-dimer value and severe infection were the independent risk factors for late PE (P<0.05). Conclusions BMI, IHT are the risk factors for early PE and severe infection is the risk factor for late PE. In addition, a high postoperative D-dimer level has a strong relationship with both early PE and late PE.

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D‐dimer level in liver transplant recipients on the first day after surgery is correlated with postoperative thrombosis recurrence

Abstract: D-dimer level on the first day after liver transplant is related to thrombosis recurrence and is an independent risk factor for postoperative thrombosis recurrence.

Cited by 3 publications

References 37 publications

D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children

D-dimer Level Is Non-Specifically Elevated Post-Living-Related Liver Transplantation in Children

Asymptomatic Venous Thromboembolism After Hepatobiliary–Pancreatic Surgery: Early Detection Using D‐dimer and Soluble Fibrin Monomer Complex Levels

Comparison and Risk factors of early and late pulmonary embolism in patients after major cancer surgery

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