D-dimer as a diagnostic and prognostic plasma biomarker in patients with a first episode of acute pericarditis

Lazaros, George; Vlachakis, Panagiotis; Theofilis, Panagiotis; Dasoula, Foteini; Imazio, Massimo; Lazarou, Emilia; Vlachopoulos, Charalambos; Tsioufis, Costas

doi:10.1016/j.ejim.2023.06.017

European Journal of Internal Medicine

2023

DOI: 10.1016/j.ejim.2023.06.017

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D-dimer as a diagnostic and prognostic plasma biomarker in patients with a first episode of acute pericarditis

George Lazaros

Panagiotis Vlachakis

Panagiotis Theofilis

et al.

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Cited by 4 publications

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“…This finding was consistent with a previous study and suggested that DD could be perceived as a measure of the inflammatory burden. 29 Reactive thrombocytosis has already been described in the context of inflammatory conditions. 30 Therefore, in patients with high DD, a significantly higher platelet count was also detected in this work.…”

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The Important Role of Preoperative D-Dimer in Constrictive Pericarditis

Fang,

Zhong,

et al. 2024

TCRM

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Background:The impact of coagulation indicators on postoperative outcomes of patients with constrictive pericarditis undergoing pericardiectomy has been poorly investigated. This study aimed to assess the prognostic role of preoperative coagulation indicators in these patients. Methods: We retrospectively included 158 patients with constrictive pericarditis undergoing pericardiectomy. The diagnostic values of coagulation indicators for postoperative complications were evaluated by ROC curves. Patients were divided into two groups according to the cutoff value calculated by ROC curve. Postoperative outcomes were compared between the two groups. Logistic regression analysis was performed to identify risk factors of postoperative complications. Results: ROC curve showed that among different coagulation indicators, preoperative D-dimer (DD) level could effectively identify patients with postoperative complications (AUC 0.771, 95% CI 0.696-0.847, P < 0.001). Patients were divided into the low DD group and the high DD group. The comparison of postoperative outcomes suggested that high preoperative DD level was significantly associated with longer durations of vasoactive agents using (P = 0.018), intubation (P = 0.020), ICU stay (P = 0.008), chest drainage (P=0.004) and hospital stay (P = 0.002). Multivariable analysis showed that high preoperative DD level was the independent risk factor of postoperative complications (OR 6.892, 95% CI 2.604-18.235, P < 0.001). Conclusion: High preoperative DD level was significantly linked to poor postoperative outcomes and could provide an effective prediction ability for postoperative complications in patients with constrictive pericarditis.

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The Important Role of Preoperative D-Dimer in Constrictive Pericarditis

Fang,

Zhong,

et al. 2024

TCRM

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D-Dimer and procalcitonin in patients with recurrent pericarditis: a prospective study

Mauro,

Bizzi,

et al. 2024

Intern Emerg Med

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Inflammatory puzzle: Unveiling the role of D-Dimer in acute pericarditis and thromboinflammation

Bizzi

Brucato

2023

European Journal of Internal Medicine

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D-dimer as a diagnostic and prognostic plasma biomarker in patients with a first episode of acute pericarditis

Cited by 4 publications

References 33 publications

The Important Role of Preoperative D-Dimer in Constrictive Pericarditis

The Important Role of Preoperative D-Dimer in Constrictive Pericarditis

D-Dimer and procalcitonin in patients with recurrent pericarditis: a prospective study

Inflammatory puzzle: Unveiling the role of D-Dimer in acute pericarditis and thromboinflammation

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