D‐dimer and its relationship to fibrinogen/fibrin degradation products (FDPs) in disorders associated with activation of coagulation or fibrinolytic systems

Abstract

Levels of D-dimer and fibrinogen/fibrin degradation products (FDPs) are significantly elevated in patients with deep venous thrombosis, pulmonary embolism, disseminated intravascular coagulation, or other complications. The diagnosis of these disorders can be difficult, time-consuming, and expensive. Assays for the detection of FDPs and D-dimer are used in many laboratories to investigate these disorders. The aim of this study was to compare plasma D-dimer levels obtained by the immuno-turdimetric method (Liatest D-Dimer Diagnostica Stago, Asnières, France) with plasma FDPs were measured by latex agglutination to investigate the relationship between these parameters. These immunoassays were tested in 144 blood samples from patients with suspected disorders associated with activation of coagulation or fibrinolytic systems. D-dimer and FDPs assays were performed in plasma samples by the use of Liatest D-dimer and plasma FDPs (Diagnostica Stago), respectively. Patients were divided into four groups according to plasma D-dimer levels. In group 1, 47.4% had negative FDPs and 52.6% had positive FDPs. In group 2, 15.4% had negative FDPs and 84.6% had positive FDPs. In group 3, 10.3% had negative FDPs and 89.7% had positive FDPs. All of the patients in group 4 had positive FDPs. It was shown that plasma D-dimer levels measured by Liatest D-dimer have a relation to FDP levels measured by latex agglutination.

Association between plasma levels of D-dimer and fibrinogen/fibrin degradation products (FDP) for exclusion of thromboembolic disorders

“…D-dimer is the more appropriate laboratory test for investigating thromboembolic disease but there is no need to run D-dimer unless suspect primary fibrinogenolysis if FDP >20 μg/mL. We recently reported a relationship between D-dimer and FDP levels in the investigation of disorders associated with activation of fibrinolytic or coagulation systems, and D-dimer levels >1420 ng/mL were directly associated to positive FDP [17]. Ddimer is the smallest cross-linked fibrin degradation product.…”

Plasma Fibrinogen and D-dimer in Children With Sepsis: A Single-center Experience

“…D-dimer, formed on cleavage of cross linked fibrin is a specific marker of fibrinolysis.It is identified in the blood of patients with various thrombotic and thrombolytic disorders (6). It is reported that levels of D-dimer increase in patients with sepsis due to fibrinolysis (7).…”

Estimation of the levels of D-dimer by use of an alternative method based in the reaction time of fibrinogen/fibrin degradation products assay

“…It is not applicable to plasma samples containing FDP <20 lg/mL. We recently reported a relationship between D-dimer and FDP levels in the investigation of disorders associated with activation of fibrinolytic or coagulation systems, and D-dimer levels >1,420 ng/mL were directly associated to positive FDP [17]. D-dimer is the smallest cross-linked fibrin degradation product.…”